The Effect of Mirror Therapy on Cerebral Re-organization, Functional Motor Skills, and Quality of Life in Hemiplegic Cerebral Palsy

NCT03612128 | Completed

• 1 other identifier: 7603
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate brain reorganization, functional motor development, level of daily living activity and quality of life of upper extremity mirror therapy in children with spastic hemiplegic cerebral palsy. Several studies have reported increased use of the affected arm following rearrangement of cerebral re-organization with mirror therapy. The investigator's study is the first of its kind and was planned to evaluate the effectiveness of upper extremity mirror therapy in cerebral reorganization and functional motor skills in children with spastic hemiplegic cerebral palsy. Hypothesis of this study is that mirror therapy improves brain re-organisation, functional motor skills and daily living activities in unilateral spastic CP.

Conditions

Spastic Hemiplegic Cerebral Palsy

Keywords

cerebral palsy; mirror therapy; cerebral re-organization; upper extremity; daily life activities; functional motor capacity; motor functions

Outcome Measures

Primary Outcomes (2)

• Functional Magnetic Resonance Imaging (fMRI)

  Brain reorganization was assessed by functional magnetic resonance imaging (fMRI).Being a non-invasive method, FMRI is nowadays the most common method used to map the neural activity of the human brain. fMRI is also used to describe patterns of cortical activation in children and adults with brain lesions

  change from baseline brain reorganization at 8 weeks

• Quality of upper extremity skills assessment (QUEST)

  Quality of upper extremity skills assessment was be assessed by Quality of Upper Extremity Skills Test (QUEST). The test evaluates that handcraft and the quality of the movement in children with CP.This is an objective standardized measure evaluating the quality of upper extremity function in 4 domains: dissociated movement, grasp, protective extension, and weight bearing. Scores for the QUEST are calculated as percentages with a maximum score of 100.

  change from baseline upper extremity skills at 8 weeks

Secondary Outcomes (2)

• Functional independence measure (WeeFIM)

  change from baseline functional independence at 8 weeks

• Child Health Questionnaire Parent Form 50 Questions (CHQ-PF50)

  change from baseline quality of life at 8 weeks

Study Arms (2)

control group

OTHER

Children continued their traditional physiotherapy

Other: control group

intervention group

ACTIVE COMPARATOR

We applied mirror therapy in addition to traditional physiotherapy

Other: intervention group

Interventions

control group OTHER

Children continued their traditional physiotherapy including upper limb exercises in three times a week for 8 week.

Also known as: traditional physiotherapy

control group

intervention group OTHER

Participants allocated to the experimental group completed three times a week, 8-week mirror therapy in addition to traditional physiotherapy . This protocol consisted of mirror therapy with a mirror box.

Also known as: mirror therapy in addition to traditional physiotherapy

intervention group

Eligibility Criteria

• Age: 4 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Congenital spastic hemiplegic cerebral palsy,
• Between the ages of 4-18,
• Continuing physiotherapy and rehabilitation program throughout the study.

You may not qualify if:

• Upper extremity fracture or muscle-tendon and bone operation shortly before 6 months,
• Any pharmacologic agent that will inhibit spasticity within 6 months,
• Visual function disorder except eye fracture defect

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University

Ankara, 06100, Turkey (Türkiye)

Location

Related Publications (5)

• Fedrizzi E, Pagliano E, Andreucci E, Oleari G. Hand function in children with hemiplegic cerebral palsy: prospective follow-up and functional outcome in adolescence. Dev Med Child Neurol. 2003 Feb;45(2):85-91.

  PMID: 12578233 BACKGROUND

• Siebes RC, Wijnroks L, Vermeer A. Qualitative analysis of therapeutic motor intervention programmes for children with cerebral palsy: an update. Dev Med Child Neurol. 2002 Sep;44(9):593-603. doi: 10.1017/s0012162201002638.

  PMID: 12227614 BACKGROUND

• Odding E, Roebroeck ME, Stam HJ. The epidemiology of cerebral palsy: incidence, impairments and risk factors. Disabil Rehabil. 2006 Feb 28;28(4):183-91. doi: 10.1080/09638280500158422.

  PMID: 16467053 BACKGROUND

• Skold A, Josephsson S, Eliasson AC. Performing bimanual activities: the experiences of young persons with hemiplegic cerebral palsy. Am J Occup Ther. 2004 Jul-Aug;58(4):416-25. doi: 10.5014/ajot.58.4.416.

  PMID: 15315248 BACKGROUND

• Gygax MJ, Schneider P, Newman CJ. Mirror therapy in children with hemiplegia: a pilot study. Dev Med Child Neurol. 2011 May;53(5):473-6. doi: 10.1111/j.1469-8749.2011.03924.x. Epub 2011 Mar 17.

  PMID: 21410693 BACKGROUND

MeSH Terms

Conditions

Cerebral Palsy

Interventions

Control Groups; Mirror Movement Therapy

Condition Hierarchy (Ancestors)

Brain Damage, Chronic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods; Physical Therapy Modalities; Rehabilitation; Therapeutics

Study Officials

• Duygu Korkem, PhD

  Uskudar University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Researcher

Model Details: In this type of controlled clinical trials, the same subjects are used as experimental and control groups, ie both the new treatment method and the classical method or the placebo method are applied to the same subjects. The efficacy is applied to the new treatment method and on the other hand the classical method is applied on the same subjects at different times and the results are compared.

Study Record Dates

• First Submitted: July 27, 2018
• First Posted: August 2, 2018
• Study Start: January 12, 2015
• Primary Completion: December 19, 2016
• Study Completion: March 13, 2017
• Last Updated: August 3, 2018

Record last verified: 2018-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)