Effects of Different Sports Supplements on Metabolism and Perceptual Responses During Distance Running

NCT03596788 | Terminated

• 1 other identifier: 1223706-2
• Study Type: interventional
• Target: 4
• Locations: 1 country
• Sites: 1

Brief Summary

Several previous studies have shown that repeatedly ingesting carbohydrate supplements during exercise training sessions, over a period of days and weeks, can gradually increase carbohydrate oxidation and reduce gut discomfort during exercise. However, repeatedly ingesting large amounts of carbohydrate during training sessions can be burdensome and can cause gut distress. Thus, it would be advantageous if the same long-term benefits could be realized from consuming these carbohydrate supplements at rest instead of specifically during training sessions. Therefore, the goal of this study is to examine whether repeatedly ingesting a carbohydrate-rich beverage at rest over a 5-day period alters metabolism and gut symptoms while ingesting carbohydrate during exercise.

Conditions

Anomalies Gastrointestinal

Outcome Measures

Primary Outcomes (2)

• Change in Gastrointestinal Symptom Ratings

  Symptoms such as nausea, fullness, belching, reflux, abdominal cramps, flatulence, and urge to defecate will be recorded on a 0-10 scale (0 = no discomfort, 10 = unbearable discomfort).

  Symptoms will be collected during a 60 minute run on a treadmill at a baseline visit and at a second visit after ingesting the carbohydrate or placebo beverage for 5 days.

• Change in Hydrogen Breath Production

  Samples of expired air will be tested for hydrogen levels, a marker of carbohydrate malabsorption

  Samples will be collected before after a 60-minute run at a baseline visit and at a second visit after ingesting the carbohydrate or placebo beverage for 5 days.

Secondary Outcomes (2)

• Change in Carbohydrate Oxidation

  Respiratory gases will be collected during each 60-minute run at a baseline visit and at a second visit after ingesting the carbohydrate or placebo beverage for 5 days.

• Change in Feeling Scale

  Ratings will be collected collected before and during each 60-minute run at a baseline visit and at a second visit after ingesting the carbohydrate or placebo beverage for 5 days.

Study Arms (2)

Carbohydrate Beverage

EXPERIMENTAL

A glucose-fructose beverage mixture supplying 100 grams of carbohydrate per day for 5 days

Dietary Supplement: Carbohydrate Beverage

Placebo Beverage

PLACEBO COMPARATOR

An artificially-sweetened beverage containing aspartame

Dietary Supplement: Placebo Beverage

Interventions

Carbohydrate Beverage DIETARY_SUPPLEMENT

The carbohydrate beverage will supply approximately 100 grams of carbohydrate per day (in the form of glucose and fructose)

Carbohydrate Beverage

Placebo Beverage DIETARY_SUPPLEMENT

The placebo beverage will contain aspartame.

Placebo Beverage

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Be currently running ≥15 miles per week
• Have completed at least one run \>60 minutes over the past month
• Have completed one or more marathons within the past year

You may not qualify if:

• Overt cardiovascular disease or metabolic disorder
• Adverse symptoms (e.g., unusual shortness of breath, dizziness, chest pain) with exercise
• Allergies/intolerances to any of the ingredients in the beverages

Sponsors & Collaborators

• Old Dominion University: lead

Study Sites (1)

Human Performance Lab

Norfolk, Virginia, 23529, United States

Location

Study Officials

• Patrick Wilson, PhD

  Old Dominion University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 28, 2018
• First Posted: July 24, 2018
• Study Start: August 1, 2018
• Primary Completion: February 17, 2025
• Study Completion: February 17, 2025
• Last Updated: March 20, 2025

Record last verified: 2025-03

Locations

US (1)