Bio-psycho-social Pathways Underlying the Effects of Qigong Among Comorbid Depressed Elderly With Chronic Conditions

NCT03591211 | Completed

• 1 other identifier: 81173316-2
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

Depression and chronic medical conditions are common in older adults. Qigong is increasingly documented to have anti-depressive effects for older adults. Nevertheless, the scientific concepts behind qigong remain a mystery. To fill the knowledge gap, the neurobiological mechanism of the effects of qigong was explored. In addition, the benefits of qigong on subjective well-being, functional independence, sleep quality, mobility, and muscle strength were also tested. After random assignment, intervention group (n = 14) went through individual qigong exercise twice a week and for 12 weeks,whereas control group (n = 16) was involved in cognitive training activities with mobilization elements. The psychosocial, physical, and neurobiological outcomes of the two groups were compared.

Conditions

Chronic Disease; Depressive Symptoms

Outcome Measures

Primary Outcomes (1)

• Patient Health Questionnaire (PHQ)

  Patient Health Questionnaire (PHQ) is used to assess the experience of depressive symptoms. The frequency of each symptom was indicated based on a 4-point scale (0 = never; 3 = almost every day). A total score ranged from 0 to 27 can be derived, with higher score indicating severer depressive symptoms.

  the change from baseline to the completion of intervention (12 weeks later)

Secondary Outcomes (9)

• Salivary Cortisol Level

  baseline and 12 weeks after baseline

• Brain Deprived Neurotrophic Factor (BDNF) Level

  baseline and 12 weeks after baseline

• Serotonin 5-HT Level

  baseline and 12 weeks after baseline

• Depression Anxiety Stress Scale (DASS-21)

  baseline, 12 weeks after baseline, and 16 weeks after baseline

• Personal Well-Being Index (PWI)

  baseline, 12 weeks after baseline, and 16 weeks after baseline

Study Arms (2)

Qigong Training

EXPERIMENTAL

Behavioral: Qigong Training

Cognitive Training

ACTIVE COMPARATOR

Behavioral: Cognitive Training

Interventions

Qigong Training BEHAVIORAL

Eight-Section Brocades; participants were trained individually.

Qigong Training

Cognitive Training BEHAVIORAL

Cognitive Training of Memory and Executive Function with Activities requiring Mobilization

Cognitive Training

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• aged 60 or above
• have been suffering from chronic medical conditions for more than one year
• have depressive symptoms as indicated by Geriatric Depression Scale (GDS ≥ 6)

You may not qualify if:

• have practiced or received training of any form of mind-body exercises (including tai chi, yoga, and qigong) during the 6 months prior to intervention.
• have changed medication or the dosage prior to or during intervention
• have obvious cognitive and language impairment or score less than 20 in Mini-Mental State Examination (MMSE)
• undergo electroconvulsive therapy, psychotherapy, or psychoeducation
• cannot demonstrate satisfactory sitting balance

Sponsors & Collaborators

• The Hong Kong Polytechnic University: lead
• I-Shou University: collaborator
• Fujian University of Traditional Chinese Medicine: collaborator

Study Sites (1)

The Hong Kong Polytechinic University

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Chronic Disease; Depression

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Neurological Rehabilitation; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Head of Department of Rehabilitation Sciences

Study Record Dates

• First Submitted: June 26, 2018
• First Posted: July 19, 2018
• Study Start: August 1, 2017
• Primary Completion: January 31, 2018
• Study Completion: February 28, 2018
• Last Updated: July 31, 2018

Record last verified: 2018-07

Locations

HK (1)