Efficacy of Licorice on Reducing Salivary Streptococcus Mutans Versus Chlorohexidine in Caries Risk Patients
Evaluation the Efficacy of a Herbal Licorice on Reducing Salivary Streptococcus Mutans Levels (A Randomized Clinical Trial)
1 other identifier
interventional
52
0 countries
N/A
Brief Summary
To compare the effect of a natural herbal licorice containing preventive measure alternative to chlorohexidine preventive measure to decrease the effect of streptococcus mutans.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Sep 2018
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 5, 2018
CompletedFirst Posted
Study publicly available on registry
July 18, 2018
CompletedStudy Start
First participant enrolled
September 1, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 30, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2019
CompletedJuly 18, 2018
July 1, 2018
12 months
July 5, 2018
July 17, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
salivary bacterial count
streotococcus mutans bacterial count
after one week
Study Arms (2)
licorice extract mouthwash
EXPERIMENTALadministration of a mouthwash containing licorice as a preventive measure to high caries risk patients (faculty of pharmacy, cairo university)
chlorohexidine mouthwash
PLACEBO COMPARATORadministration of chlorohexidine 0.2% in 1:1 diluation mouthwash that is broad spectrum antimicrobial activity to high caries risk patients
Interventions
mouth rinse that contains a natural herbal licorice root extract used as a preventive measure that reduce caries index.
mouth wash that contains chlorohexidine as an active component
Eligibility Criteria
You may qualify if:
- over 18 years old
- co-operative patients
- not allergic to licorice
- not allergic to chlorohexidine
You may not qualify if:
- pregnancy
- allergic patients to licorice
- allergic patients to chlorohexidine
- lack of compliance
- evidence of parafunctional habits
- patients with periodontal disease
- xerostomia
- participants that receive any microbial agent two weeks prior to the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
Related Publications (2)
Almaz ME, Sonmez IS, Okte Z, Oba AA. Efficacy of a sugar-free herbal lollipop for reducing salivary Streptococcus mutans levels: a randomized controlled trial. Clin Oral Investig. 2017 Apr;21(3):839-845. doi: 10.1007/s00784-016-1827-y. Epub 2016 Apr 30.
PMID: 27129589BACKGROUNDJain E, Pandey RK, Khanna R. Liquorice root extracts as potent cariostatic agents in pediatric practice. J Indian Soc Pedod Prev Dent. 2013 Jul-Sep;31(3):146-52. doi: 10.4103/0970-4388.117964.
PMID: 24021323BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
nancy helmy, Msc
Faculty of Dentistry, Cairo univerisity
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant lecturer
Study Record Dates
First Submitted
July 5, 2018
First Posted
July 18, 2018
Study Start
September 1, 2018
Primary Completion
August 30, 2019
Study Completion
October 1, 2019
Last Updated
July 18, 2018
Record last verified: 2018-07
Data Sharing
- IPD Sharing
- Will not share