Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid
1 other identifier
interventional
28
0 countries
N/A
Brief Summary
This study will be conducted to evaluate the effect of arginine versus fluoride containing toothpaste on neutralization of microbial acid produced by Cariogenic bacteria in adult population using chair side assessment method.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jun 2017
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 4, 2017
CompletedFirst Posted
Study publicly available on registry
May 8, 2017
CompletedStudy Start
First participant enrolled
June 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2018
CompletedMay 9, 2017
May 1, 2017
6 months
May 4, 2017
May 6, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
salivary pH
Salivary pH will be determined by use of a digital pH meter .All salivary pH values will be taken immediately following salivary collection at chairside. The salivary pH values measured before usage of toothpaste termed "resting pH," while the salivary pH values measured after usage of toothpaste termed "terminal pH.
10 minutes after intervention and control
Study Arms (2)
arginine toothpaste
EXPERIMENTALfluoride toothpaste
ACTIVE COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Participants should be over 18 years of age.
- Systematically healthy.
- Not taking any medication interfering with saliva secretion.
- Participants who signed informed consent.
You may not qualify if:
- Participants with a compromised medical history.
- Participants under systemic disease treatment, with antibiotic, steroid or any medication known to cause dry mouth.
- Severe or active periodontal disease.
- History of allergies or other adverse reactions to arginine, or oral care product or their ingredient.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- CARE PROVIDER, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Resident of conservative departement , Faculty of Oral and Dental Medicine, Cairo university,2013
Study Record Dates
First Submitted
May 4, 2017
First Posted
May 8, 2017
Study Start
June 1, 2017
Primary Completion
December 1, 2017
Study Completion
February 1, 2018
Last Updated
May 9, 2017
Record last verified: 2017-05