Chitosan,Chitosan Nanoparticles,and Chlorhexidine Gluconate, as Intra Canal Medicaments in Primary Teeth

NCT03588351 | Unknown DMC

• 1 other identifier: PED-3-17
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

Aim of the present study is to assess the in vivo susceptibility of root canal bacteria to Chitosan,Chitosan nanoparticles ,and Chlorhexidine gluconate when used as intra canal medicaments in necrotic primary molars

Conditions

Necrotic Pulp

Outcome Measures

Primary Outcomes (1)

• assess the in vivo susceptibility of root canal bacteria to Chitosan,Chitosan nanoparticals ,and Chlorhexidine gluconate when used as intra canal medicaments in necrotic primary molars.

  antibacterial effect of Chlorhexidine Gluconate, Chitosan,Chitosan Nanoparticl on necrotic primary tooth

  3 month

Study Arms (3)

chlorhexidine gluconate

ACTIVE COMPARATOR

GROUP I: - 15 teeth will be treated with specially prepared gel containing chlorhexidine gluconate as intracanal medicament .

Drug: chlorhexidine gluconate

chitosan nanoparticles gel

EXPERIMENTAL

GROUP II: - 15 teeth will be treated with specially prepared gel containing chitosan nanoparticles that ready to use as intracanal medicament.

Drug: chitosan nanoparticles gel

chitosan gel

EXPERIMENTAL

Group III: 15teeth will be treated with specially prepared gell containing chitosan that ready to use as intra medicament .

Drug: chitosan gel

Interventions

chitosan nanoparticles gel DRUG

intracanal medicament

Also known as: CSNPs

chitosan nanoparticles gel

chitosan gel DRUG

intracanal medicament

Also known as: CS

chitosan gel

chlorhexidine gluconate DRUG

intracanal medicament

Also known as: CHX

chlorhexidine gluconate

Eligibility Criteria

• Age: 4 Years - 7 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Apparently healthy children.
• Age 4-7 years
• Children should have at least one non vital and restorable mandibular molar .
• Cooperative children.
• Children that did not take any antibiotic for at least one month before sample collection

You may not qualify if:

• Medically compromised children.
• Children under antibiotic therapy.
• Non restorable molars.
• Root resorption more then half of the root length.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain shames university faculty of dentistry

Cairo, Egypt

Location

MeSH Terms

Conditions

Dental Pulp Necrosis

Interventions

chlorhexidine gluconate

Condition Hierarchy (Ancestors)

Dental Pulp Diseases; Tooth Diseases; Stomatognathic Diseases; Necrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Marwa A Abozed, BDSC

  Faculty of Dentistry Ain shams University, Cairo, Egypt

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Marwa Ahmed Abozed

Study Record Dates

• First Submitted: July 5, 2018
• First Posted: July 17, 2018
• Study Start: January 1, 2018
• Primary Completion: August 15, 2018
• Study Completion: August 30, 2018
• Last Updated: July 17, 2018

Record last verified: 2018-07

Locations

EG (1)