NCT03583450

Brief Summary

The goal of this study is to evaluate the use of immersive audiovisual distraction and virtual reality to reduce perioperative anxiety in pediatric patients undergoing surgery at UCSF Benioff Children's Hospital. The study plans to employ virtual reality headsets during induction of anesthesia in pediatric patients for elective surgery in a randomized clinical trial.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
71

participants targeted

Target at P25-P50 for not_applicable anxiety

Timeline
Completed

Started Aug 2018

Shorter than P25 for not_applicable anxiety

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 18, 2018

Completed
23 days until next milestone

First Posted

Study publicly available on registry

July 11, 2018

Completed
2 months until next milestone

Study Start

First participant enrolled

August 29, 2018

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 27, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 27, 2019

Completed
1.3 years until next milestone

Results Posted

Study results publicly available

July 8, 2020

Completed
Last Updated

July 8, 2020

Status Verified

June 1, 2020

Enrollment Period

7 months

First QC Date

June 18, 2018

Results QC Date

April 6, 2020

Last Update Submit

June 15, 2020

Conditions

Keywords

Virtual RealityPediatric Anesthesia

Outcome Measures

Primary Outcomes (2)

  • Perioperative Pediatric Anxiety (Change From Baseline)

    Modified Yale Preoperative Anxiety Scale (Observational measure of anxiety in five categories (activity, emotional expressivity, state of arousal, vocalization, and use of parents); Total range 0 to 100 with higher scores indicating greater anxiety)

    (Day 0 + 15 minutes on average from initial baseline) On entering the OR

  • Perioperative Pediatric Anxiety (Change From Baseline)

    Modified Yale Preoperative Anxiety Scale (Observational measure of anxiety in five categories (activity, emotional expressivity, state of arousal, vocalization, and use of parents); Total range 0 to 100 with higher scores indicating greater anxiety)

    (Day 0 + 30 minutes on average from initial baseline) During mask induction

Secondary Outcomes (3)

  • Perioperative Parental Anxiety (Change From Baseline)

    (Day 0 + 45 minutes on average from initial baseline) After mask induction

  • Induction Compliance Checklist

    (Day 0 + 30 minutes on average from initial baseline) During mask induction

  • Parental Satisfaction

    (Day 0 + 45 minutes on average from initial baseline) After mask induction

Other Outcomes (4)

  • Anesthesia Length

    (Day 0 + 120 minutes on average from initial baseline) After exiting the OR

  • Surgery Length

    (Day 0 + 120 minutes on average from initial baseline) After exiting the OR

  • Pre-medication Given

    (Day 0 + 30 minutes on average from initial baseline) On induction of anesthesia

  • +1 more other outcomes

Study Arms (2)

Perioperative virtual reality headset

EXPERIMENTAL

Perioperative virtual reality headset with mobile app and routine anesthetic care

Device: Perioperative virtual reality headset with mobile app

Control

NO INTERVENTION

Routine anesthetic care

Interventions

Perioperative virtual reality headset with mobile app (Samsung Gear VR headset, ChariotVR software)

Perioperative virtual reality headset

Eligibility Criteria

Age5 Years - 12 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Patients aged 5-12 years
  • Patients present in preoperative area for induction of general anesthesia for an elective surgery or procedure

You may not qualify if:

  • Patients with injuries to the head/face that would prohibit wearing of headsets
  • Patients with loss of consciousness, altered mental status, life-threatening injuries/illness or multi-trauma
  • Patients with open skin, lice, scabies, or other infectious skin conditions on the head/face
  • Patients with a history of or current symptoms of vertigo
  • Patients who are blind
  • Patients with significant developmental or cognitive delays who may not be able to engage with or tolerate the virtual reality environment, as determined by their parent/caregiver
  • Patients on whom the VR headset does not fit appropriately
  • Non-English speaking patients (due to limited availability of non-English study documents and consents)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

UCSF Benioff Children's Hospital

San Francisco, California, 94158, United States

Location

Related Publications (1)

  • Jung MJ, Libaw JS, Ma K, Whitlock EL, Feiner JR, Sinskey JL. Pediatric Distraction on Induction of Anesthesia With Virtual Reality and Perioperative Anxiolysis: A Randomized Controlled Trial. Anesth Analg. 2021 Mar 1;132(3):798-806. doi: 10.1213/ANE.0000000000005004.

MeSH Terms

Conditions

Anxiety Disorders

Condition Hierarchy (Ancestors)

Mental Disorders

Results Point of Contact

Title
Dr. Jina Sinskey
Organization
University of California, San Francisco

Study Officials

  • Michael Jung

    UCSF Medical Center

    PRINCIPAL INVESTIGATOR
  • Jina Sinskey, MD

    University of California, San Francisco

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 18, 2018

First Posted

July 11, 2018

Study Start

August 29, 2018

Primary Completion

March 27, 2019

Study Completion

March 27, 2019

Last Updated

July 8, 2020

Results First Posted

July 8, 2020

Record last verified: 2020-06

Locations