Relationship Between Oral Health Status and Unexplained Female Infertility in Turkish Population

NCT03575494 | Withdrawn

• 1 other identifier: 40465587-177
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Periodontal diseases and dental caries are initiated by a pathogenic biofilm, in a susceptible host, affecting the tooth periodontium and hard tissues. Its possible association with many biologic systems has been studied. In this study, researchers investigated association between oral health and female infertility, and what is the biological rationale for such relationship.

Conditions

Dental Caries; Female Infertility

Outcome Measures

Primary Outcomes (1)

• female infertility

  Women with normal hormone values and uterine cavity with at least one healthy fallopian tube. All male partners have a semen specimen with minimum 5 million motile sperm in the ejaculate.

  12 months

Secondary Outcomes (1)

• dental examination

  1 Day

Study Arms (2)

female infertility

Women who had regular menses and can't conceive despite a long-term regular sexual intercourse for more than 12 months

Other: Intraoral and Radiographic Dental Examination

healthy

healthy patients who had minimum two normal pregnancies

Other: Intraoral and Radiographic Dental Examination

Interventions

Intraoral and Radiographic Dental Examination OTHER

(ORTHOPANTOMOGRAPH® OP300 PANORAMIC, Instrumentarium Dental, Tuusula, Finland,63 kVp, 0.8 mA, 0.5 s).

female infertility; healthy

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients were aged from 18 to 35 years, 100 females

You may qualify if:

• Women who had regular menses and can't conceive despite a long-term regular sexual intercourse for more than 12 months
• Women with normal hormone values and uterine cavity with at least one healthy fallopian tube.
• All male partners have a semen specimen with minimum 5 million motile sperm in the ejaculate.
• The control group members have minimum two normal pregnancies

You may not qualify if:

• Patients who have history of f; hydrosalpinx, polycystic ovarian syndrome, endometriosis grade 3-4, thyroid disease, tubal surgery, hyperprolactinemia, autoimmune diseases, diabetes mellitus, uterine/cervical anomalies, active liver disease, cardiovascular disease, premature ovarian failure, smoking and alcohol consumption, poor socioeconomic level, HIV-infected, obesity (body mass index ≥ 30 kg/m2), chronic upper respiratory tract diseases and dental fluorosis.
• Patients using fluoride supplements and orthodontic appliances

Sponsors & Collaborators

• Recep Tayyip Erdogan University Training and Research Hospital: lead

Study Sites (1)

Recep Tayyip Erdogan University

Rize, 53000, Turkey (Türkiye)

Location

Related Publications (1)

• Khanna SS, Dhaimade PA, Malhotra S. Oral Health Status and Fertility Treatment Including IVF. J Obstet Gynaecol India. 2017 Dec;67(6):400-404. doi: 10.1007/s13224-017-1025-0. Epub 2017 Jun 20.

  PMID: 29162952 BACKGROUND

Related Links

• Oral Health Status and Fertility Treatment

MeSH Terms

Conditions

Dental Caries; Infertility, Female

Condition Hierarchy (Ancestors)

Tooth Demineralization; Tooth Diseases; Stomatognathic Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Infertility

Study Officials

• Gül Yıldız Telatar

  Recep Tayyip Erdogan University Dentistry Faculty

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Recep Tayyip Erdogan University Faculty of Dentistry

Study Record Dates

• First Submitted: June 22, 2018
• First Posted: July 2, 2018
• Study Start: April 15, 2018
• Primary Completion: April 15, 2019
• Study Completion: February 15, 2020
• Last Updated: October 8, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)