Prevalence of Abnormal Postures in Parkinson's Disease

NCT03573232 | Unknown DMC

• 1 other identifier: Università di Verona
• Study Type: observational
• Target: 794
• Locations: 1 country
• Sites: 7

Brief Summary

Postural abnormalities represent disabling and painful complications in patients with Parkinson's disease (PD). The stooped posture is a typical feature of PD but with advancing of disease more severe body abnormalities can affect people with PD. These deformities include Pisa syndrome, camptocormia, antecollis, scoliosis and striatal deformities related to hand (striatal hand) and/or toes (striatal toes).

Conditions

Parkinson Disease

Keywords

Parkinson Disease; Pisa Syndrome; Camptocormia; Antecollis; Striatal deformities

Outcome Measures

Primary Outcomes (1)

• The prevalence of postural deformities

  % of people with Parkinson's disease reporting Pisa syndrome, camptocormia, antecollis, scoliosis and striatal deformities related to hand (striatal hand) and toes (striatal toes).

  1 day

Secondary Outcomes (37)

• Data of birth

  1 day

• Sex

  1 day

• Body Mass Index

  1 day

• SPECIFIC EVALUATION FOR PATIENTS WITH PARKINSON'S DISEASE • Age at PD onset

  1 day

• Disease duration of PD

  1 day

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

In the present multicenter study, consecutive outpatients with PD attending 7 movement disorders Italian tertiary centers (Verona, Ancona, Chieti, Pisa, Torino, Trieste, Roma) will be invited to participate. Participants will be considered enrolled after signing the consent form.

You may qualify if:

• Participants will be considered enrolled after signing the consent form;
• Diagnosis of Parkinson's disease;

You may not qualify if:

• Concomitant neurologic diseases known to negatively affect posture;
• A history of major spinal surgery or muscle and/or skeletal diseases;
• Treatment with drugs potentially able to induce abnormal postures;
• Clinical features consistent with a diagnosis of atypical parkinsonism;

Sponsors & Collaborators

• Universita di Verona: lead

Study Sites (7)

Department of Experimental and Clinical Medicine - University "Politecnica delle Marche" Ancona -Italy. Neurorehabilitation Clinic - Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona.

Ancona, Italy

RECRUITING

Department of Neuroscience, Imaging and Clinical Sciences, University G.d'Annunzio of Chieti-Pescara

Pescara, Italy

RECRUITING

Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

Pisa, Italy

RECRUITING

IRCCS San Raffaele CTC Centro Parkinson Via della Pisana 235, 00163 Roma

Roma, Italy

RECRUITING

Dipartimento di Neuroscienze A.O. Città della Salute e della Scienza di Torino

Torino, Italy

RECRUITING

Clinica Neurologica, Dipartimento di Scienze Neurologiche, Chirurgiche e della Salute, Azienda Ospedaliera Universitaria integrata, Universita' di Trieste

Trieste, Italy

RECRUITING

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona

Verona, 37134, Italy

RECRUITING

Related Publications (4)

• Doherty KM, van de Warrenburg BP, Peralta MC, Silveira-Moriyama L, Azulay JP, Gershanik OS, Bloem BR. Postural deformities in Parkinson's disease. Lancet Neurol. 2011 Jun;10(6):538-49. doi: 10.1016/S1474-4422(11)70067-9. Epub 2011 Apr 22.

  PMID: 21514890 BACKGROUND

• Tinazzi M, Geroin C, Gandolfi M, Smania N, Tamburin S, Morgante F, Fasano A. Pisa syndrome in Parkinson's disease: An integrated approach from pathophysiology to management. Mov Disord. 2016 Dec;31(12):1785-1795. doi: 10.1002/mds.26829. Epub 2016 Oct 25.

  PMID: 27779784 BACKGROUND

• Srivanitchapoom P, Hallett M. Camptocormia in Parkinson's disease: definition, epidemiology, pathogenesis and treatment modalities. J Neurol Neurosurg Psychiatry. 2016 Jan;87(1):75-85. doi: 10.1136/jnnp-2014-310049. Epub 2015 Apr 20.

  PMID: 25896683 BACKGROUND

• Pandey S, Garg H. Postural & striatal deformities in Parkinson;s disease: Are these rare? Indian J Med Res. 2016 Jan;143(1):11-7. doi: 10.4103/0971-5916.178577.

  PMID: 26997007 BACKGROUND

MeSH Terms

Conditions

Parkinson Disease; Camptocormia

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Michele Tinazzi, MD, PhD, Professor

  Universita di Verona

  PRINCIPAL INVESTIGATOR

• Nicola Smania, MD, Professor

  Universita di Verona

  STUDY CHAIR

• Marialuisa Gandolfi, MD, PhD

  Universita di Verona

  STUDY CHAIR

• Christian Geroin, PhD

  Universita di Verona

  STUDY CHAIR

Central Study Contacts

Michele Tinazzi, MD, PhD, Professor

CONTACT

0458124287; michele.tinazzi@univr.it

Christian Geroin, PhD

CONTACT

christian.geroin@univr.it

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D., Ph.D. Full Professor

Study Record Dates

• First Submitted: May 7, 2018
• First Posted: June 29, 2018
• Study Start: March 7, 2018
• Primary Completion: October 7, 2018
• Study Completion: October 7, 2018
• Last Updated: July 17, 2018

Record last verified: 2018-07

Data Sharing

• IPD Sharing: Will not share

Locations

IT (7)