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Outcome Measures

Primary Outcomes (1)

Pressure pain threshold (PPT)
Change in the pressure pain threshold (kPa) recorded after the induced of muscle pain using SWD on the established time point records.
0 to 1 hour

Secondary Outcomes (11)

Assessment of changes in pain intensity in direct relation to the experimental model
0 to 1 hour
Assessment of changes in pain time course in direct relation to the experimental model
0 to 1 hour
Assessment of changes in functional connectivity in direct relation to the experimental model
0 to 1 hour
Assessment of changes in Pinprick sensitivity
0 to 1 hour
Assessment of changes in Dynamic tactile sensitivity
0 to 1 hour
+6 more secondary outcomes

Interventions

Short-wave diathermyRadiation

The application of SWD will be carried out by a CEC M-8 short-wave thermotherapy unit. The device has capacitive applicators, that will be situated around the muscle to be irradiated on top of a cotton towel, in order to absorb perspiration and avoid undesired heating effects. Afterwards the emission mode (continuous or pulsed) will be selected, and application of SWD will start. The intensity of SWD will be gradually increased until the volunteer perceives a warm sensation, and once familiarized with this perception, the intensity will be increased until a sensation of constant but tolerable pain is evoked. This sensation will be maintained throughout the duration of the SWD application, estimated in approximately 10 minutes.

Healthy participant

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Related Publications (4)

Goats GC. Continuous short-wave (radio-frequency) diathermy. Br J Sports Med. 1989 Jun;23(2):123-7. doi: 10.1136/bjsm.23.2.123.

PMID: 2691003BACKGROUND

Graven-Nielsen T. Fundamentals of muscle pain, referred pain, and deep tissue hyperalgesia. Scand J Rheumatol Suppl. 2006;122:1-43. doi: 10.1080/03009740600865980. No abstract available.

PMID: 16997767BACKGROUND

Neziri AY, Scaramozzino P, Andersen OK, Dickenson AH, Arendt-Nielsen L, Curatolo M. Reference values of mechanical and thermal pain tests in a pain-free population. Eur J Pain. 2011 Apr;15(4):376-83. doi: 10.1016/j.ejpain.2010.08.011. Epub 2010 Oct 6.

Study Design

Study Type

interventional

Phase

not applicable

Allocation

Masking

NONE

Purpose

BASIC SCIENCE

Intervention Model

SINGLE GROUP

Model Details: The SWD applicators will be placed in the desired position, around the forearm for the upper limb experiments, or below the knee for the lower limb experiments. The distance between applicators will be adjusted until the desired pain sensation is obtained according to the subjective criterion of the volunteer. This sensation should be mild or moderate pain, but tolerable for the duration of the application. Once the first application is completed, the volunteer will be allowed to rest for a period of 10 minutes, and the assessment will be repeated to test for possible after effects. After it is verified that the muscles recovered their normal temperature and the pain sensation has completely disappeared, the variables related to changes in motor responses under rest conditions will be recorded. Then SWD will be applied a second time using the same parameters as in the first application. Once the registration is complete, the experiment will be finished.

Sponsor Type

OTHER GOV

Responsible Party

PRINCIPAL INVESTIGATOR

PI Title

Principal Investigator

A New Experimental Model of Transient and Short-lasting Muscle Pain in Humans Based on Diathermy

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Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (11)

Study Arms (1)

Healthy participant

Interventions

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Study Sites (1)

Related Publications (4)

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Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (11)

Study Arms (1)

Healthy participant

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (4)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

Data Sharing

Source record

Locations