Cardiac Arrest Survival Score (CRASS)

NCT03571113 | Completed

• 1 other identifier: 2018-1
• Study Type: observational
• Target: 8,603
• Locations: 0 countries
• Sites: N/A

Brief Summary

Survival following cardiopulmonary resuscitation (CPR) from out-of-hospital cardiac arrest (OHCA) depends on numerous prehospital and in-hospital variables and interventions. The aim of this study was to develop a score to predict the resuscitation outcome after OHCA at hospital discharge. All patients suffered OHCA between 01.01.2010 and 31.12.2016 with ROSC or ongoing CPR at hospital admission in Emergency Medical Service (EMS) systems with good quality in documentation in the German Resuscitation Registry (GRR) were included. The study population was divided into development dataset (5,775) and validation dataset (1,457) by random. Binary logistic regression analysis was used to derive the score. Hospital discharge with good neurological function (CPC 1-2 or mRS 0-2) was used as dependent variable, and various combination of potential predictor variables were used to create the model.

Conditions

Cardiac Arrest

Keywords

cardiac arrest, OHCA survival score, predicting survival, German Resuscitation Registry

Outcome Measures

Primary Outcomes (1)

• good neurological outcome

  CPC 1 and 2 or mRS 0-2

  30 days after OHCA

Study Arms (2)

Development

The study population was divided into two parts by random: development dataset (5,775) and validation dataset (1,457)

Other: Survival / not survival

Validation

The study population was divided into two parts by random: development dataset (5,775) and validation dataset (1,457)

Other: Survival / not survival

Interventions

Survival / not survival OTHER

Outcome with good neurological status vs. bad neurological status at hospital discharge

Development; Validation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Between 01.01.2010 and 31.12.2016 the 'Preclinical care' dataset contained 8,603 out-of-hospital CA patients with return of spontaneous circulation (ROSC) or ongoing CPR at hospital admission in EMS systems with good documentation quality.

You may qualify if:

• OHCA between 01.01.2010 and 31.12.2016
• ROSC or ongoing CPR on hopsital admission
• high quality documentation with more than 75% documentation of post resuscitation care in hospital
• Patients cases documented in German Resuscitation Registry
• Between 01.01.2010 and 31.12.2016 the 'Preclinical care' dataset contained 8,603 out-of-hospital CA patients with return of spontaneous circulation (ROSC) or ongoing CPR at hospital admission in EMS systems with good documentation quality. Good quality of documentation was defined by documented post-resuscitation care in more than 75%.

You may not qualify if:

• incomplete dataset
• age less than 18 years
• unknown initial ECG
• unknown age
• unknown neurological status on hospital discharge
• ,371 patients were excluded from further analysis because of incomplete data in terms of age, neurological status at hospital discharge, unknown initial EKG or age \< 18 years.

Sponsors & Collaborators

• German Resuscitation Registry: lead

Related Publications (1)

• Grasner JT, Meybohm P, Lefering R, Wnent J, Bahr J, Messelken M, Jantzen T, Franz R, Scholz J, Schleppers A, Bottiger BW, Bein B, Fischer M; German Resuscitation Registry Study Group. ROSC after cardiac arrest--the RACA score to predict outcome after out-of-hospital cardiac arrest. Eur Heart J. 2011 Jul;32(13):1649-56. doi: 10.1093/eurheartj/ehr107. Epub 2011 Apr 22.

  PMID: 21515626 BACKGROUND

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Jan-Thorsten Gräsner, MD

  Institute for Emergency Medicine, Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 16, 2018
• First Posted: June 27, 2018
• Study Start: January 1, 2010
• Primary Completion: December 31, 2016
• Study Completion: December 31, 2016
• Last Updated: February 5, 2020

Record last verified: 2020-02

Data Sharing

• IPD Sharing: Will not share