Optic Nerve Sheath Diameter for Prediction of Outcome After Cardiac Arrest

NCT02513628 | Completed

• 1 other identifier: MelunH
• Study Type: observational
• Target: 36
• Locations: 0 countries
• Sites: N/A

Brief Summary

Early prognostication in resuscitated cardiac arrest (CA) patients, within the first day after admission in the intensive care unit (ICU), remains difficult. Optic nerve sheath diameter (ONSD) measurement could predict increased intracranial pressure. Preliminary works showed that ONSD measurement could be used to predict outcome in post-CA patients. The aim of this study was to assess the ability of bedside ONSD ultrasonographic measurement to predict survival and Cerebral Performance Category (CPC) score at hospital discharge in post-cardiac arrest patients treated with therapeutic hypothermia (TH).

Conditions

Cardiac Arrest

Keywords

Cardiac arrest; neuroprognostication; optic nerve sheath diameter; outcome; ultrasonography

Outcome Measures

Primary Outcomes (1)

• In-hospital mortality

  participants will be followed for the duration of hospital stay, an expected average of 3 months.

  3 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All unconscious (Glasgow Coma Scale ≤6) patients ≥18 years old, admitted in ICU after successful resuscitation from CA, and treated with TH targeted to 33°C were screened. Exclusion criteria were as follows: unavailable ONSD measurement within 24 hours after return of spontaneous circulation (unavailable investigator, early death, or major hemodynamic instability), traumatic or neurological origin of CA, previous cerebrovascular disease, facial trauma affecting the orbits and/or eyeballs, and previous history of ocular pathology such as exophthalmia, glaucoma or cataract.

You may qualify if:

• Unconscious (Glasgow Coma Scale ≤6)
• ≥18 years old
• Admitted in ICU after successful resuscitation from CA
• Treated with TH targeted to 33°C

You may not qualify if:

• unavailable ONSD measurement within 24 hours after return of spontaneous circulation (unavailable investigator, early death, or major hemodynamic instability)
• Traumatic or neurological origin of CA
• Previous cerebrovascular disease
• Facial trauma affecting the orbits and/or eyeballs
• Previous history of ocular pathology such as exophthalmia, glaucoma or cataract.

Sponsors & Collaborators

• Hopital of Melun: lead

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: July 24, 2015
• First Posted: July 31, 2015
• Study Start: November 1, 2011
• Primary Completion: September 1, 2013
• Study Completion: January 1, 2014
• Last Updated: July 31, 2015

Record last verified: 2015-07