NCT03562338

Brief Summary

The aim of this study is to develop a predictive model to identify which patients with chronic nonspecific neck pain are more likely to benefit from manual therapy and exercise program, or usual care.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jun 2018

Shorter than P25 for not_applicable

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 24, 2018

Completed
18 days until next milestone

Study Start

First participant enrolled

June 11, 2018

Completed
8 days until next milestone

First Posted

Study publicly available on registry

June 19, 2018

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2019

Completed
Last Updated

June 19, 2018

Status Verified

June 1, 2018

Enrollment Period

8 months

First QC Date

May 24, 2018

Last Update Submit

June 18, 2018

Conditions

Keywords

chronic nonspecific neck paindisabilitypredictive modelrehabilitationpain intensity

Outcome Measures

Primary Outcomes (6)

  • Change from baseline in Neck Pain Intensity as measured by the Numeric pain rating scale (NRPS) at 3 weeks.

    The change will be defined on the Minimal Clinically Important Difference in treatment response defined as a decrease of ≥2 point in NRPS (range: 0 - 10 points).

    3 weeks

  • Change from baseline in Neck Pain Intensity as measured by the Numeric pain rating scale (NRPS) at 6 weeks.

    The change will be defined on the Minimal Clinically Important Difference in treatment response defined as a decrease of ≥2 point in NRPS (range: 0 - 10 points).

    6 weeks

  • Change from baseline in Neck Pain Intensity as measured by the Numeric pain rating scale (NRPS) at follow-up 3 months.

    The change will be defined on the Minimal Clinically Important Difference in treatment response defined as a decrease of ≥2 point in NRPS (range: 0 - 10 points).

    Follow-up 3 months

  • Change from baseline in Neck Disability as measured by the Neck Disability Index (NDI) at 3 weeks.

    The change will be defined on the Minimal Clinically Important Difference in treatment response defined as a decrease of ≥27% in NDI (range: 0-50 and higher scores are indicative of more disability).

    3 weeks

  • Change from baseline in Neck Disability as measured by the Neck Disability Index (NDI) at 6 weeks.

    The change will be defined on the Minimal Clinically Important Difference in treatment response defined as a decrease of ≥27% in NDI (range: 0-50 and higher scores are indicative of more disability).

    6 weeks

  • Change from baseline in Neck Disability as measured by the Neck Disability Index (NDI) at follow-up 3 months.

    The change will be defined on the Minimal Clinically Important Difference in treatment response defined as a decrease of ≥27% in NDI (range: 0-50 and higher scores are indicative of more disability).

    Follow-up 3 months

Secondary Outcomes (3)

  • Clinical Important Treatment response in global perceived recovery as measured by Patient's Global Impression of Change Scale at 3 weeks

    3 weeks

  • Clinical Important Treatment response in global perceived recovery as measured by Patient's Global Impression of Change Scale at 6 weeks

    6 weeks

  • Clinical Important Treatment response in global perceived recovery as measured by Patient's Global Impression of Change Scale at follow-up 3 months

    Follow-up 3 months

Study Arms (2)

Manual Therapy and Exercise

EXPERIMENTAL
Other: Manual Therapy and Exercise (Physiotherapy Intervention)

Usual Care

ACTIVE COMPARATOR
Other: Usual Care (Physiotherapy Intervention)

Interventions

Participants in this group will receive a 6-weeks program of mobilization and progressive exercise for the neck flexors, 2 times a week.

Manual Therapy and Exercise

Participants in this group will receive usual care in physiotherapy during the 6-weeks period.

Usual Care

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Chronic nonspecific neck pain at least 3 months, defined as pain in the cervical region without a specific anatomopathological diagnosis;
  • Adults between 18 and 65 years of age and literate in Portuguese;

You may not qualify if:

  • History of cervical trauma and/or history of surgery in the prior 6 months;
  • Clinical signs of infection, tumor, neurological, inflammatory or systemic diseases;
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Pain

Interventions

Musculoskeletal ManipulationsExercise

Condition Hierarchy (Ancestors)

Neurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Complementary TherapiesTherapeuticsPhysical Therapy ModalitiesRehabilitationMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Lúcia Domingues

    NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
SCREENING
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 24, 2018

First Posted

June 19, 2018

Study Start

June 11, 2018

Primary Completion

February 1, 2019

Study Completion

February 1, 2019

Last Updated

June 19, 2018

Record last verified: 2018-06