Nutrient Supplementation Influences Mitochondria Adaptation

NCT03561337 | Completed DMC

• 1 other identifier: AURunners2017
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 2

Brief Summary

Twenty-four well trained runners (VO2max 60.73.7 ml O2 Kg-1 min1) completed a six week block randomized controlled intervention period. Subjects were randomly assigned to either PRO-CHO or CHO and matched in pairs for gender, age, VO2max, training and performance status. The PRO- CHO group ingested a protein beverage (0.3g kg-1) before and protein-carbohydrate beverage (0.3g protein kg-1 and 0.1g carbohydrate kg-1) after each exercise session. The CHO group ingested energy matched carbohydrate. Post-absorptive muscle biopsies were obtained pre and post intervention for analysis HAD, CS and PGC-1. Subjects completed two physical tests 6 km performance test (pre, week 1 and week 6) and aVo2max test (pre and post intervention).

Conditions

Performance; Nutrition; Protein

Outcome Measures

Primary Outcomes (1)

• Maximal oxygen uptake

  maximal oxygen uptake (L O2/min)

  Change from week 1 to week 6

Secondary Outcomes (6)

• VDAC

  Change from week 1 to week 6

• CytC

  Change from week 1 to week 6

• Performance

  Change from week 1 to week 6

• COX-IV

  Change from week 1 to week 6

• HSP60

  Change from week 1 to week 6

Study Arms (2)

PROTEIN-CARBOHYDRATE

EXPERIMENTAL

Intervention group receiving protein and carbohydrate supplement

Dietary Supplement: PROTEIN-CARBOHYDRATE

CARBOHYDRATE

PLACEBO COMPARATOR

Intervention groups receiving carbohydrate supplement

Dietary Supplement: CARBOHDYRATE

Interventions

PROTEIN-CARBOHYDRATE DIETARY_SUPPLEMENT

PRO before and PRO-CHO after training

PROTEIN-CARBOHYDRATE

CARBOHDYRATE DIETARY_SUPPLEMENT

CHO before and after training

CARBOHYDRATE

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• maximal oxygen uptake (VO2max) of \>50ml O2 kg-1 min-1 for women and \>55ml O2 kg-1 min-1 for men,
• running at least 3 times a week and
• running being the primarily training form

You may not qualify if:

• use of medicine
• diagnosed metabolic diseases
• injuries which hindered running and body mass index (BMI) \< 25 kg m-2

Sponsors & Collaborators

• University of Aarhus: lead

Study Sites (2)

Aarhus University, Department for Public Health, Section for Sport Science

Aarhus, 8000, Denmark

Location

Sport Science, Department of Public Health, Aarhus University

Aarhus, 8000, Denmark

Location

Related Publications (1)

• Hansen M, Oxfeldt M, Larsen AE, Thomsen LS, Rokkedal-Lausch T, Christensen B, Rittig N, De Paoli FV, Bangsbo J, Ortenblad N, Madsen K. Supplement with whey protein hydrolysate in contrast to carbohydrate supports mitochondrial adaptations in trained runners. J Int Soc Sports Nutr. 2020 Sep 7;17(1):46. doi: 10.1186/s12970-020-00376-3.

  PMID: 32894140 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Single blinded
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Model Details: block randomized controlled intervention

Study Record Dates

• First Submitted: December 1, 2017
• First Posted: June 19, 2018
• Study Start: October 1, 2013
• Primary Completion: February 1, 2014
• Study Completion: June 1, 2014
• Last Updated: May 14, 2020

Record last verified: 2020-05

Data Sharing

• IPD Sharing: Will not share

Locations

DK (2)