The Pre-hospital Evaluation of Sensitive Troponin (PRESTO) Study
2 other identifiers
observational
700
1 country
13
Brief Summary
The aim of the study is to assess whether a decision aid that is currently used in hospitals across Greater Manchester to determine how likely it is that a patient has a serious heart problem is still accurate in the pre-hospital environment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2018
Longer than P75 for all trials
13 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 6, 2018
CompletedFirst Posted
Study publicly available on registry
June 19, 2018
CompletedStudy Start
First participant enrolled
October 16, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2025
CompletedMay 1, 2024
April 1, 2024
6.2 years
June 6, 2018
April 30, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Diagnosis of acute myocardial infarction
30 days
Secondary Outcomes (3)
Incident major adverse cardiac events
30 days
Prevalent acute myocardial infarction
30 days
Final diagnosis of participant
30 days
Eligibility Criteria
The study will recruit patients who have called 999 with a complaint of pain, discomfort or pressure in the chest, who are then attended by an ambulance.
You may qualify if:
- Adult patients (\>18 years)
- Called 999 for an emergency ambulance because they have experienced pain, discomfort or pressure in the chest, epigastrium, neck, jaw or upper limb without an apparent non-cardiac source
- Treating paramedic suspects these symptoms may be caused by acute coronary syndromes.
You may not qualify if:
- Patients with unequivocal evidence of ST elevation myocardial infarction who are being immediately transferred for primary percutaneous coronary intervention
- Patients in whom an alternative diagnosis (other than acute coronary syndromes) is suspected, which would necessitate transfer to hospital
- Patients who have not experienced symptoms in the previous 24 hours
- Patients who lack the capacity to provide written informed consent, either because they lack the mental capacity to provide written informed consent or because effective communication is not possible (e.g. non-English speakers in the absence of adequate translation services)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Manchester University NHS Foundation Trustlead
- National Institute for Health Research, United Kingdomcollaborator
- Abbott Point of Carecollaborator
- LumiraDxcollaborator
- Roche Diagnostics GmbHcollaborator
Study Sites (13)
Bolton NHS Foundation Trust
Bolton, United Kingdom
North West Ambulance Service NHS Trust
Bolton, United Kingdom
North Bristol NHS Trust
Bristol, United Kingdom
University Hospitals Coventry and Warwickshire NHS Trust
Coventry, United Kingdom
West Midlands Ambulance Service NHS Foundation Trust
Dudley, United Kingdom
Royal Devon and Exeter NHS Foundation Trust
Exeter, United Kingdom
South Western Ambulance Service NHS Foundation Trust
Exeter, United Kingdom
Manchester University NHS Foundation Trust
Manchester, United Kingdom
Plymouth Hospitals NHS Trust
Plymouth, United Kingdom
Salford Royal NHS Foundation Trust
Salford, United Kingdom
Taunton and Somerset NHS Foundation Trust
Taunton, United Kingdom
South Warwickshire NHS Foundation Trust
Warwick, United Kingdom
Wrightington, Wigan and Leigh NHS Foundation Trust
Wigan, United Kingdom
Related Publications (3)
Gilman J, Alghamdi A, Hann M, Carlton E, Cooper JG, Cook E, Siriwardena AN, Phillips J, Thompson A, Bell S, Kirby K, Rosser A, Body R. Diagnostic Accuracy of a Novel Point of Care High-Sensitivity Troponin Assay in the Prehospital Environment. Acad Emerg Med. 2026 Jan;33(1):e70213. doi: 10.1111/acem.70213.
PMID: 41528153DERIVEDAlghamdi A, Hann M, Carlton E, Cooper JG, Cook E, Foulkes A, Siriwardena AN, Phillips J, Thompson A, Bell S, Kirby K, Rosser A, Body R. Diagnostic Accuracy of Clinical Pathways for Suspected Acute Myocardial Infarction in the Out-of-Hospital Environment. Ann Emerg Med. 2023 Oct;82(4):439-448. doi: 10.1016/j.annemergmed.2023.04.010. Epub 2023 Jun 10.
PMID: 37306636DERIVEDAlghamdi A, Cook E, Carlton E, Siriwardena A, Hann M, Thompson A, Foulkes A, Phillips J, Cooper J, Bell S, Kirby K, Rosser A, Body R. PRe-hospital Evaluation of Sensitive TrOponin (PRESTO) Study: multicentre prospective diagnostic accuracy study protocol. BMJ Open. 2019 Oct 28;9(10):e032834. doi: 10.1136/bmjopen-2019-032834.
PMID: 31662404DERIVED
Biospecimen
Plasma samples
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Richard Body
Manchester University NHS Foundation Trust
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 6, 2018
First Posted
June 19, 2018
Study Start
October 16, 2018
Primary Completion
January 1, 2025
Study Completion
January 1, 2025
Last Updated
May 1, 2024
Record last verified: 2024-04
Data Sharing
- IPD Sharing
- Will not share