The Effect of Acute Mild Dehydration on Blood Pressure Control
Sympathetic Reactivity to Water Restriction in Young and Older Adults
3 other identifiers
interventional
35
1 country
1
Brief Summary
The goal of this project is determine how acute mild dehydration impacts blood pressure control at rest and during static exercise. This protocol will test healthy young and older adults in a normally hydrated and dehydrated condition.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Aug 2017
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 8, 2017
CompletedFirst Submitted
Initial submission to the registry
June 6, 2018
CompletedFirst Posted
Study publicly available on registry
June 18, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 13, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
June 13, 2019
CompletedResults Posted
Study results publicly available
January 27, 2021
CompletedJanuary 27, 2021
January 1, 2021
1.8 years
June 6, 2018
October 5, 2020
January 5, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Blood Pressure Variability
Blood pressure variability (BPV) was calculated using standard deviation and using the average real variability index of blood pressure values. The average real variability index calculates the average of absolute differences between consecutive BP measurements and is thought to provide further prognostic value compared with traditional measures of BPV.
During experimental visits 1 and 2
Blood Pressure Reactivity - Handgrip Exercise
Change in systolic blood pressure during the second-minute handgrip exercise minus compared to pre-exercise baseline (i.e., at rest).
During experimental visits 1 and 2
Study Arms (2)
Normal hydration then dehydration
EXPERIMENTALParticipants will consume water to maintain proper hydration for three days prior to testing (visit 1). Seven to 60 days later, participants will reduce water intake over three days and abstain from any water for the final 16 hours prior to testing (visit 2).
Dehydration than normal hydration
EXPERIMENTALParticipants will reduce water intake over three days and abstain from any water for the final 16 hours prior to testing (visit 1). Seven to 60 days later, participants will consume water to maintain proper hydration for three days prior to testing (visit 2).
Interventions
see description in 'arms'
see description in 'arms'
Eligibility Criteria
You may qualify if:
- age: 20-35 years old
You may not qualify if:
- high blood pressure (\>140/90 mmHg)
- history of cardiovascular disease
- history of cancer
- history of diabetes
- history of kidney disease
- obesity (BMI \> 30 kg/m2)
- smoking or tobacco use
- current pregnancy
- nursing mothers
- communication barriers
- age: 60-75 years old
- ECG within normal limits
- screening blood panel within normal limits
- high blood pressure (\>140/90 mmHg)
- history of cardiovascular disease
- +8 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
William B Farquhar
Newark, Delaware, 19713, United States
Related Publications (3)
Watso JC, Robinson AT, Babcock MC, Migdal KU, Wenner MM, Stocker SD, Farquhar WB. Short-term water deprivation does not increase blood pressure variability or impair neurovascular function in healthy young adults. Am J Physiol Regul Integr Comp Physiol. 2020 Jan 1;318(1):R112-R121. doi: 10.1152/ajpregu.00149.2019. Epub 2019 Oct 16.
PMID: 31617739RESULTWatso JC, Babcock MC, Robinson AT, Migdal KU, Wenner MM, Stocker SD, Farquhar WB. Water deprivation does not augment sympathetic or pressor responses to sciatic afferent nerve stimulation in rats or to static exercise in humans. J Appl Physiol (1985). 2019 Jul 1;127(1):235-245. doi: 10.1152/japplphysiol.00005.2019. Epub 2019 May 9.
PMID: 31070954RESULTRobinson AT, Babcock MC, Watso JC, Brian MS, Migdal KU, Wenner MM, Farquhar WB. Relation between resting sympathetic outflow and vasoconstrictor responses to sympathetic nerve bursts: sex differences in healthy young adults. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R463-R471. doi: 10.1152/ajpregu.00305.2018. Epub 2019 Feb 22.
PMID: 30794437RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- William B. Farquhar
- Organization
- University of Delaware
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 6, 2018
First Posted
June 18, 2018
Study Start
August 8, 2017
Primary Completion
June 13, 2019
Study Completion
June 13, 2019
Last Updated
January 27, 2021
Results First Posted
January 27, 2021
Record last verified: 2021-01