NCT03554759

Brief Summary

Phase 4 observational cohort study to characterize the treatment patterns and effects of avatrombopag use in patients with thrombocytopenia associated with chronic liver disease who are either undergoing, or have already undergone, a procedure.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jul 2018

Shorter than P25 for all trials

Geographic Reach
1 country

41 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 22, 2018

Completed
22 days until next milestone

First Posted

Study publicly available on registry

June 13, 2018

Completed
19 days until next milestone

Study Start

First participant enrolled

July 2, 2018

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 31, 2019

Completed
Last Updated

October 21, 2024

Status Verified

October 1, 2024

Enrollment Period

7 months

First QC Date

May 22, 2018

Last Update Submit

October 17, 2024

Conditions

Keywords

Chronic Liver DiseaseLow Platelet Count

Outcome Measures

Primary Outcomes (1)

  • Change in platelet count

    Up to 8 days after the last dose of avatrombopag.

Secondary Outcomes (2)

  • Proportion of patients who received a platelet transfusion

    From the first dose of avatrombopag to up to 15 days after the last dose of avatrombopag

  • Occurrence of adverse events

    From the first dose of avatrombopag to up to 30 days after the last dose of avatrombopag

Interventions

Avatrombopag dosing will be determined by the treating physician in conjunction with the FDA-approved package insert.

Eligibility Criteria

Age18 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients ≥18 years of age who have thrombocytopenia associated with chronic liver disease and are planned for or underwent treatment with avatrombopag prior to a procedure.

You may qualify if:

  • Patient has thrombocytopenia associated with chronic liver disease and is planned for or underwent treatment with avatrombopag prior to a procedure
  • Patient provides written informed consent
  • Minimum Data for Retrospective Enrollment
  • Platelet count from approximately 7 days prior to starting avatrombopag
  • Platelet count on Procedure Day

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (41)

Dova Site

Chandler, Arizona, 85224, United States

Location

Dova Site

Lancaster, California, 93534, United States

Location

Dova Study Site

Los Angeles, California, 90048, United States

Location

Dova Site

Palm Springs, California, 92262, United States

Location

Dova Study Site

Pasadena, California, 91107, United States

Location

Dova Study Site

San Clemente, California, 92673, United States

Location

Dova Study Site

San Diego, California, 92114, United States

Location

Dova Study Site

San Diego, California, 92121, United States

Location

Dova Study Site

Aurora, Colorado, 80045, United States

Location

Dova Study Site

Englewood, Colorado, 80113, United States

Location

Dova Study Site

Gainesville, Florida, 32610, United States

Location

Dova Study Site

Miami, Florida, 33136, United States

Location

Dova Study Site

Atlanta, Georgia, 30309, United States

Location

Dova Study Site

Topeka, Kansas, 66606, United States

Location

Dova Study Site

Louisville, Kentucky, 40202, United States

Location

Dova Study Site

Baltimore, Maryland, 21202, United States

Location

Dova Study Site

Boston, Massachusetts, 02215, United States

Location

Dova Study Site

Burlington, Massachusetts, 01805, United States

Location

Dova Study Site

Worcester, Massachusetts, 01655, United States

Location

Dova Study Site

Ann Arbor, Michigan, 48109, United States

Location

Dova Study Site

Detroit, Michigan, 48239, United States

Location

Dova Site

Jackson, Mississippi, 39216, United States

Location

Dova Study Site

New Brunswick, New Jersey, 08901, United States

Location

Dova Study Site

Manhasset, New York, 11030, United States

Location

Dova Study Site

New York, New York, 10016, United States

Location

Dova Study Site

The Bronx, New York, 10467, United States

Location

Dova Study Site

Durham, North Carolina, 27710, United States

Location

Dova Study Site

Cleveland, Ohio, 44016, United States

Location

Dova Study Site

Columbus, Ohio, 43210, United States

Location

Dova Study Site

Flourtown, Pennsylvania, 19031, United States

Location

Dova Site

Philadelphia, Pennsylvania, 19141, United States

Location

Dova Study Site

Pittsburgh, Pennsylvania, 15213, United States

Location

Dova Study Site

Johnson City, Tennessee, 37604, United States

Location

Dova Study Site

Memphis, Tennessee, 38104, United States

Location

Dova Study Site

Union City, Tennessee, 38261, United States

Location

Dova Study Site

Dallas, Texas, 75234, United States

Location

Dova Study Site

Houston, Texas, 77030, United States

Location

Dova Study Site

Charlottesville, Virginia, 22908, United States

Location

Dova Study Site

Richmond, Virginia, 23226, United States

Location

Dova Study SIte

Roanoke, Virginia, 24014, United States

Location

Dova Study Site

Milwaukee, Wisconsin, 53226, United States

Location

MeSH Terms

Conditions

Thrombocytopenia

Interventions

avatrombopag

Condition Hierarchy (Ancestors)

Blood Platelet DisordersHematologic DiseasesHemic and Lymphatic DiseasesCytopenia

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 22, 2018

First Posted

June 13, 2018

Study Start

July 2, 2018

Primary Completion

January 31, 2019

Study Completion

January 31, 2019

Last Updated

October 21, 2024

Record last verified: 2024-10

Locations