The Neural Representation of Self in Depression Patients

NCT03551041 | Completed

• 1 other identifier: DepressionSelf_fMRI
• Study Type: observational
• Target: 23
• Locations: 0 countries
• Sites: N/A

Brief Summary

To be aware of oneself as a unique entity in the world occurs early in human development and is the prerequisite of normal social functioning. The disturbance of self representation characterizes a variety of mental disorders such as autism and schizophrenia. Negative self-bias was found to serve as the core cognitive mechanism of depression disorder. However, there was no evidence to show the reason lead to negative bias. In the current study, investigators hypothesized that the blurring self representation was the neural correlates in depression disorder.

Conditions

Depression Disorder; Healthy

Keywords

depression, self-referential, neural representation

Outcome Measures

Primary Outcomes (1)

• Neural representation of self

  We adopted the self referential task. In the task, participants were asked to judge whether a given word was appropriate to describe oneself (self-judgement condition), a celebrity (other-judgement condition) by pressing one of the two buttons with the index or middle finger. For judgments of each target person (i.e, self and celebrity), there were 3 categories of words describing the mental (personality traits, such as hard-working, friendly), physical (physical attributes, such as black hair, big eyes) and social (social roles, such as student, American) dimension of person knowledge. The fMRI task contained 6 runs, with 4.6 minutes per run. This paradigm and task allowed us to investigated the neural representation of self by comparing the BOLD activity under self-judgement condition with BOLD activity under other-judgement condition.

  through study completion, an average of 2 year

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Individuals diagnosed with depression and healthy control

You may qualify if:

• Patients should be clinical diagnosis of major depression disorder.
• Healthy control participants should be age-matched with depression group, and should have no history of neurological or psychiatric diagnoses

You may not qualify if:

• Patients who also have bipolar disorder, schizophrenia, anxiety disorder
• Healthy controls who have history of mental disorders

Sponsors & Collaborators

• Beijing Normal University: lead
• Peking University: collaborator
• Southwest Medical University: collaborator

MeSH Terms

Conditions

Depression

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 4, 2018
• First Posted: June 11, 2018
• Study Start: May 27, 2014
• Primary Completion: June 15, 2017
• Study Completion: January 26, 2018
• Last Updated: June 11, 2018

Record last verified: 2018-02

Data Sharing

• IPD Sharing: Will not share