Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise

NCT03540602 | Unknown Phase 1

• 1 other identifier: Polyphenol Supplementation
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Strength training is commonly used as an intervention to increase muscle mass, thus improving a person's ability to undertake activities of daily living, or enhance athletic performance. The strength training regimen itself, while ultimately having beneficial effects, causes muscle fibers to be damaged, which the body has to recover from. As the body recovers, it rebuilds the muscle tissue and after multiple consecutive bouts of strength training, the muscle eventually becomes larger and stronger. Thus, it is the recovery from strength training exercise that ultimately determines how well the body adapts. Where inadequate recovery could eventually lead to overtraining and/or injury, optimizing the recovery process from strength training could maximize strength training adaptations. This concept of optimizing recovery has led to development of many supplements, including antioxidants, which may reduce the damage associated with strength training activities and therefore enhance positive adaptations. The purpose of this study is to assess the ability of a polyphenol rich supplementation to aid the recovery process from a demanding bout of resistance exercise

Conditions

Muscle Soreness

Keywords

Polyphenol rich supplementation; Tart cherry; Lifting; Recovery

Outcome Measures

Primary Outcomes (1)

• Assessment of Oxidative Stress

  Blood analyses will be used, 8 mL of blood will be taken from the participant six times per condition. The blood will be centrifuged to separate the serum/ plasma and analyzed by enzyme- linked immunosorbent assay (ELISA) for c- reactive protein and creatine kinase, and oxidative damage

  7 weeks

Secondary Outcomes (2)

• Muscle soreness

  7 weeks

• Vertical Jump Performance

  7 weeks

Study Arms (2)

Placebo

PLACEBO COMPARATOR

Rice flour capsule

Other: Placebo Oral Capsule [CEBOCAP]

Polyphenol Rich Supplement

ACTIVE COMPARATOR

NordicCherry Tart Cherry Extract Powder 500 mg in capsule form

Dietary Supplement: Tart Cherry

Interventions

Tart Cherry DIETARY_SUPPLEMENT

NordicCherry Tart Cherry Extract Powder 500 mg from Specnova, inc

Also known as: NordicCherry Tart Cherry Extract Powder 500 mg

Polyphenol Rich Supplement

Placebo Oral Capsule [CEBOCAP] OTHER

Rice flour

Placebo

Eligibility Criteria

• Age: 21 Years - 45 Years
• Gender Eligibility Details: Must be male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• months of resistance training experience with barbel back squat exercise

You may not qualify if:

• Not currently taking any antioxidant supplements, not currently using any hormone replacement therapy or anabolic androgenic steroids.

Sponsors & Collaborators

• Jacksonville University: lead
• Specnova, inc: collaborator

Study Sites (1)

Jacksonville University

Jacksonville, Florida, 32211, United States

RECRUITING

Related Publications (4)

• Reid MB. Invited Review: redox modulation of skeletal muscle contraction: what we know and what we don't. J Appl Physiol (1985). 2001 Feb;90(2):724-31. doi: 10.1152/jappl.2001.90.2.724.

  PMID: 11160074 BACKGROUND

• Alessio HM, Goldfarb AH, Cutler RG. MDA content increases in fast- and slow-twitch skeletal muscle with intensity of exercise in a rat. Am J Physiol. 1988 Dec;255(6 Pt 1):C874-7. doi: 10.1152/ajpcell.1988.255.6.C874.

  PMID: 3202155 RESULT

• Blair SN, Cheng Y, Holder JS. Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc. 2001 Jun;33(6 Suppl):S379-99; discussion S419-20. doi: 10.1097/00005768-200106001-00007.

  PMID: 11427763 RESULT

• Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev. 2008 Oct;88(4):1243-76. doi: 10.1152/physrev.00031.2007.

  PMID: 18923182 RESULT

MeSH Terms

Conditions

Myalgia

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Diseases; Nervous System Diseases; Musculoskeletal Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Heather Hausenblaus

  Jacksonville University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Heather Hausenblaus

CONTACT

904-256-7975; hhausen@ju.edu

David Hooper

CONTACT

904-256-7985; dhooper4@ju.edu

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: To ensure that all subjects and researchers are unaware of the treatment assignments we will have one outside individual that will possess the knowledge of which subjects are given which supplement and which were given a placebo. This information will remain confidential until the study has been concluded. At the conclusion of the study, participants will be informed of which condition they were assigned. in an event of an emergency or the participant decides not to participate his condition will be revealed.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: 20 male participants will start with a familiarization visit where they will receive either the placebo supplement or the polyphenol rich supplement that they will take for 7 days. After taking the supplement, the participants will come back and run through the acute resistance exercise protocol as well as return the next day for a post test. Next, the participants will undergo a "wash out" phase where they will not take any supplementation. At the end of these 2 weeks, the participants will then take the other supplement (i.e. if they took the polyphenol rich supplement in the first phase they will take the placebo supplement in the second phase). After a week of taking their assigned supplement, participants will complete the acute resistance exercise protocol and the post test.

Study Record Dates

• First Submitted: February 26, 2018
• First Posted: May 30, 2018
• Study Start: May 1, 2018
• Primary Completion: August 1, 2018
• Study Completion: August 1, 2018
• Last Updated: May 30, 2018

Record last verified: 2018-05

Locations

US (1)