Topical Eucalyptus Globulus and Mentha x Piperita on Muscle Soreness in Older Adults and the Elderly

NCT04866407 | Terminated Results

• 1 other identifier: Pro2021000112
• Study Type: interventional
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

Subjects over age 50 with no previous resistance training sessions will be recruited at a subacute rehabilitation and long term care facility. Subjects will be asked to perform a series of eccentric upper arm curl exercises under physician supervision in order to induce muscle soreness. Afterwards, topical oil containing a 2% dilution of either eucalyptus or peppermint oil in fractionated coconut oil will be applied to the flexor surface of the proximal non-dominent arm, and plain fractionated coconut oil to the other arm. This will be repeated at 8 hours and 24 hours after exercise. Subjects will be asked to report their perceived level of muscle soreness using a visual analog scale survey 24, 48, and 72 hours after exercise.

Conditions

Muscle Soreness

Keywords

Essential Oils; Muscle Soreness; Mentha x piperita; Eucalyptus globulus

Outcome Measures

Primary Outcomes (3)

• Perceived Muscle Soreness

  Perceived soreness using a visual analog scale rating from '0' to '100'; a higher score indicates more muscle soreness

  24 hours after exercise

• Perceived Muscle Soreness

  Perceived soreness using a visual analog scale rating from '0' to '100'; a higher score indicates more muscle soreness

  48 hours after exercise

• Perceived Muscle Soreness

  Perceived soreness using a visual analog scale rating from '0' to '100'; a higher score indicates more muscle soreness

  72 hours after exercise

Study Arms (3)

Mentha x piperita

EXPERIMENTAL

A diluted solution of Mentha x piperita in carrier oil will be applied to the subject's interventional extremity.

Other: Mentha x piperita

Eucalyptus globulus

EXPERIMENTAL

A diluted solution of Eucalyptus globulus in carrier oil will be applied to the subject's interventional extremity.

Other: Eucalyptus globulus

No intervention

NO INTERVENTION

Each participant will have one extremity that receives no essential oil intervention.

Interventions

Mentha x piperita OTHER

2% solution of Mentha x piperita diluted in fractionated coconut oil for topical application will be applied to one extremity of the subjects in the 'Mentha x piperita' group.

Mentha x piperita

Eucalyptus globulus OTHER

2% solution of Eucalyptus globulus diluted in fractionated coconut oil for topical application will be applied to one extremity of the subjects in the 'Eucalyptus globulus' group.

Eucalyptus globulus

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects 50 years or older with no previous resistance training sessions in the past year
• Duke Activity Screening Index functional capacity of at least 3.5 metabolic equivalents or greater
• currently admitted at the Manor Health and Rehabilitation

You may not qualify if:

• history of musculoskeletal injury or weight bearing restrictions to the upper extremities within the past year
• known adverse reaction or allergy to the essential oils or hypersensitivities to fragrances
• open upper extremity wounds or history of upper extremity skin grafts

Sponsors & Collaborators

• Rutgers, The State University of New Jersey: lead

Study Sites (1)

The Manor Health and Rehabillitation - CentraState

Freehold, New Jersey, 07728, United States

Location

Related Publications (19)

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  BACKGROUND

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  BACKGROUND

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  BACKGROUND

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  PMID: 7954745 BACKGROUND

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  BACKGROUND

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  BACKGROUND

• Tisserand, R., Young, R., & Williamson, E. M. (2014). Essential Oil Profiles: Mentha x piperita. In Essential oil safety: A guide for health care professionals (pp. 69-98). Edinburgh: Churchill Livingstone/Elsevier. (pp. 387-391)

  BACKGROUND

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MeSH Terms

Conditions

Myalgia

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Diseases; Nervous System Diseases; Musculoskeletal Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Dr Sydney Asselstine
• Organization: Rutgers RWJMS

sydneyasselstine@gmail.com

6469403587

Study Officials

• Zeeshan Khan, MD

  Rutgers RWJMS Department of Family Medicine

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician

Study Record Dates

• First Submitted: April 25, 2021
• First Posted: April 29, 2021
• Study Start: April 26, 2021
• Primary Completion: June 30, 2022
• Study Completion: June 30, 2022
• Last Updated: February 8, 2024
• Results First Posted: February 8, 2024

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)