NCT03540264

Brief Summary

Tooth wear is a physiological process occurring from normal functioning of the dentition throughout lifetime.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
52

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Feb 2018

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 26, 2018

Completed
7 days until next milestone

First Submitted

Initial submission to the registry

March 5, 2018

Completed
3 months until next milestone

First Posted

Study publicly available on registry

May 30, 2018

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2020

Completed
Last Updated

March 11, 2019

Status Verified

March 1, 2019

Enrollment Period

2.8 years

First QC Date

March 5, 2018

Last Update Submit

March 7, 2019

Conditions

Outcome Measures

Primary Outcomes (1)

  • Restoration

    by modified USPHS criteria

    up to 3 years

Study Arms (2)

Composite resin

ACTIVE COMPARATOR

Restoration with composite resin has shown good clinical performance and limited occlusal wear. The Clearfil Majesty will be used in the present study.

Device: Clearfil Majesty TM

Polymer-infiltrated-ceramic-network

ACTIVE COMPARATOR

This hybrid material seems to be a promising material that imitates natural tooth properties. The VITA-Enamic® will be used in this study.

Device: Vita-Enamic®

Interventions

Tooth wear - composite resin

Composite resin

Tooth wear - polymer-infiltrated-ceramic-network

Polymer-infiltrated-ceramic-network

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients aged 18 years or older, in good general health, willing to participate in the study and accepting to come to regular controls in the future.
  • Patients representing any type of significant tooth wear (≥ 1 mm depth) with dentine exposure in at least 4 teeth: localized tooth wear anterior or posterior teeth and generalized tooth wear anterio and posterior teeth.
  • Patients having posterior support with at least 4 molars in occlusion, 1 pair per side, excluding third molar.

You may not qualify if:

  • Patients wearing removable partial prosthesis
  • Patients presenting skeletal Cl III occlusal Relationship
  • Patients with remaining clinical crown of ≤ 3 mm in height and presenting tooth anomaly in shape and number in addition to anterior diastemas.
  • Patients with symptomatic temporomandibular joint disorders.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium

RECRUITING

MeSH Terms

Conditions

Tooth Wear

Condition Hierarchy (Ancestors)

Tooth DiseasesStomatognathic Diseases

Study Officials

  • De Carvalho Joana, Dentist, Pr

    Cliniques universitaires Saint-Luc- Université Catholique de Louvain

    PRINCIPAL INVESTIGATOR

Central Study Contacts

DE CARVALHO Joana, Dentist, Pr

CONTACT

Kanaan Mireille, Dentist

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
The statistician will be blind to the treatment assigned to indivivual patients.
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 5, 2018

First Posted

May 30, 2018

Study Start

February 26, 2018

Primary Completion

December 31, 2020

Study Completion

December 31, 2020

Last Updated

March 11, 2019

Record last verified: 2019-03

Locations