Effects of High-velocity Resistance Training and Creatine Supplementation in Healthy Aging Males

NCT03530202 | Unknown Phase 2

• 1 other identifier: URegina
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The age-related loss of skeletal muscle mass (i.e. sarcopenia)and muscle performance (i.e. strength and power), decreases functionality and the ability to perform activities of daily living. Therefore, lifestyle interventions which may improve aging muscle health are important (i.e. resistance training and creatine supplementation). High-velocity resistance training (HVRT) has been shown to increase muscle mass and muscle performance in aging adults. Creatine (CR), a compound naturally found in red meat and seafood, has also been shown to increase muscle mass and muscle performance in aging adults. No study has examined the combined effects of HVRT and CR supplementation in aging adults. This study may determine whether this lifestyle intervention is effective to combat sarcopenia.

Conditions

Sarcopenia

Keywords

muscle thickness; strength; power; functionality

Outcome Measures

Primary Outcomes (1)

• Change in muscle thickness

  Muscle thickness (right side) of the elbow flexors, elbow extensors, knee flexors, and knee extensors will be measured using B-Mode ultrasound (LOGIQ e, GE Medical Systems).

  Baseline and again once intervention is completed (8 weeks)

Secondary Outcomes (5)

• Change in muscle strength

  Baseline and again once intervention is completed (8 weeks)

• Change in peak torque (Nm)

  Baseline and again once intervention is completed (8 weeks)

• Change peak muscle power (watts)

  Baseline and again once intervention is completed (8 weeks)

• Change in dynamic balance

  Baseline and again once intervention is completed (8 weeks)

• Walking speed

  Baseline and again once intervention is completed (8 weeks)

Study Arms (2)

HVRT + Creatine Monohydrate

EXPERIMENTAL

Participants will perform 8-weeks of high-velocity resistance training, defined as performing the concentric phase of a lift as fast as possible and taking two seconds to perform the eccentric phase of the lift, on six exercises (bilateral legpress, leg extension, leg curl, chest press, triceps extension, and biceps curl) and consume creatine monohydrate powder. The load will be 80% of the participants one-repetition max (1RM; the maximum weight that can be successfully lifted one time with proper form).

Drug: Creatine monohydrate

HVRT + Maltodextrin Powder

PLACEBO COMPARATOR

Participants will perform 8-weeks of high-velocity resistance training, defined as performing the concentric phase of a lift as fast as possible and taking two seconds to perform the eccentric phase of the lift, on six exercises (bilateral legpress, leg extension, leg curl, chest press, triceps extension, and biceps curl) and consume maltodexterin powder. The load will be 80% of the participants one-repetition max (1RM; the maximum weight that can be successfully lifted one time with proper form).

Drug: Maltodextrin Powder

Interventions

Creatine monohydrate DRUG

Participants will consume creatine monohydrate powder (Creapure, AlzChem AG, Trostberg, Germany) every day for 8 weeks. On training days participants will consume supplement immediately after each training session (\~ 5 minutes) mixed in water as post-exercise creatine ingestion enhances its uptake into muscle and promotes increased muscle mass. On non-training days, supplements will be consumed at the participant's leisure.

Also known as: Creapure, AlzChem AG, Trostberg, Germany

HVRT + Creatine Monohydrate

Maltodextrin Powder DRUG

Participants will consume Maltodextrin Powder (Globe Plus 10 DE Maltodextrin Powder, Univar Canada) every day for 8 weeks. On training days participants will consume supplement immediately after each training session (\~ 5 minutes) mixed in water. On non-training days, supplements will be consumed at the participant's leisure.

Also known as: Globe Plus 10 DE Maltodextrin, Univar, Canada

HVRT + Maltodextrin Powder

Eligibility Criteria

• Age: 50 Years+
• Gender Eligibility Details: The response to creatine supplementation is inconsistent between males and females. Females may not experience the same gains in muscle mass and strength following creatine supplementation and resistance training compared to males. Although speculative, females may have higher initial intramuscular creatine stores than males which make them less responsive to supplementation. Furthermore, creatine appears to have no effect on muscle protein kinetics in females. Therefore, for the purpose of this study, only healthy aging males will be recruited.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Males (≥ 50 years) who are not engaged in supervised resistance training for ≥ 6 weeks prior to the start of the study will be recruited to participate.

You may not qualify if:

• Participants will be excluded if they have taken medications that affect muscle biology or creatine monohydrate ≤ 12 weeks prior to the start of the study
• If they have a history of fragility fractures; diseases that are known to affect muscle biology (i.e. corticoids)
• If they suffer from severe osteoarthritis
• If they are currently participating in moderate-vigorous resistance training (≥ 3 times per week)
• If they are vegetarian
• If they are planning to travel during the study period for greater than 2 weeks duration at a time.
• Participants with kidney or liver abnormalities will be excluded.

Sponsors & Collaborators

• University of Regina: lead

Study Sites (1)

University of Regina

Regina, Saskatchewan, S4S4J5, Canada

RECRUITING

Related Publications (5)

• Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007 May;39(2):175-91. doi: 10.3758/bf03193146.

  PMID: 17695343 BACKGROUND

• Candow DG, Little JP, Chilibeck PD, Abeysekara S, Zello GA, Kazachkov M, Cornish SM, Yu PH. Low-dose creatine combined with protein during resistance training in older men. Med Sci Sports Exerc. 2008 Sep;40(9):1645-52. doi: 10.1249/MSS.0b013e318176b310.

  PMID: 18685526 BACKGROUND

• Chilibeck PD, Stride D, Farthing JP, Burke DG. Effect of creatine ingestion after exercise on muscle thickness in males and females. Med Sci Sports Exerc. 2004 Oct;36(10):1781-8. doi: 10.1249/01.mss.0000142301.70419.c6.

  PMID: 15595301 BACKGROUND

• Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond). 1992 Sep;83(3):367-74. doi: 10.1042/cs0830367.

  PMID: 1327657 BACKGROUND

• Nogueira W, Gentil P, Mello SN, Oliveira RJ, Bezerra AJ, Bottaro M. Effects of power training on muscle thickness of older men. Int J Sports Med. 2009 Mar;30(3):200-4. doi: 10.1055/s-0028-1104584. Epub 2009 Feb 6.

  PMID: 19199198 BACKGROUND

MeSH Terms

Conditions

Sarcopenia

Interventions

Creatine

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Guanidines; Amidines; Organic Chemicals; Amino Acids; Amino Acids, Peptides, and Proteins

Study Officials

• Darren G Candow, PhD

  Professor, Associate Dean of Graduate Studies

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Darren G Candow, PhD

CONTACT

(306) 585-4906; Darren.Candow@uregina.ca

John P Neary, PhD

CONTACT

(306) 585-4844; Patrick.Neary@uregina.ca

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: A research assistant who is not involved in the study in any other way will be responsible for randomization.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The study will be a double-blind, repeated measures design. Participants will be randomized on a 1:1 basis to one of two groups: high-velocity resistance training and creatine or high-velocity resistance training and placebo.

Study Record Dates

• First Submitted: April 19, 2018
• First Posted: May 21, 2018
• Study Start: January 1, 2018
• Primary Completion: July 31, 2018
• Study Completion: July 31, 2018
• Last Updated: May 21, 2018

Record last verified: 2018-05

Locations

CA (1)