Semantic and Syntactic Computerized Analysis of Free Speech

NCT03525054 | Recruiting

• 1 other identifier: ASESID (29BRC17.0198)
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 3

Brief Summary

Subtle speech disorganization could be predictive of a transition to schizophrenia of ultra-high-risk patients. The aim of our longitudinal multicenter cohort study is to identify specific linguistic markers of the psychotic transition to validate a french predictive model of this transition using computerized speech analysis techniques

Conditions

Psychotic Disorders; Psychosis; Schizophrenia and Related Disorders; Schizophrenia Prodromal; Diagnosis, Psychiatric

Keywords

Psychotic Disorders; Diagnosis, Psychiatric; Schizophrenia Prodromal; Ultra High Risk; Prediction Of Psychosis; Machine Learning; Automated Language Analysis; Semantic Coherence; Syntaxic Complexity

Outcome Measures

Primary Outcomes (1)

• Transition to schizophrenia

  Determined from the CAARMS scale (COMPREHENSIVE ASSESSMENT OF AT RISK MENTAL STATES)

  2 years

Secondary Outcomes (1)

• Identification of patients at "ultra high risk " for developing schizophrenia

  Day 0

Eligibility Criteria

• Age: 15 Years - 30 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Help-seekers patients are recruited during two years from the early psychosis detection centers in Brest, France (CEVUP), Paris, France (CJAAD) and in Lausanne, Switzerland

You may qualify if:

• Major and/or minor from 15 to 30 years old
• Who alleged a suicidal gesture or idea or behavior that has repercussions in their emotional, social or professional life
• If patients receive neuroleptic treatment that impairs cognitive abilities, a one-week wash-out period will be scheduled prior to assessment.

You may not qualify if:

• History of psychosis
• Risk of self-harm or violence not compatible with outpatient treatment
• QI\<70 (WAIS)
• Neurological disorder or major health problem
• Impossibility to interrupt neuroleptic treatment for one week
• Refusal to participate

Sponsors & Collaborators

• University Hospital, Brest: lead

Study Sites (3)

CHRU de Brest

Brest, 29609, France

RECRUITING

Meunier Sophie

Caen, France

NOT YET RECRUITING

CH de SAINT ANNE

Paris, 750144, France

RECRUITING

MeSH Terms

Conditions

Psychotic Disorders; Schizophrenia; Schizotypal Personality Disorder; Mental Disorders

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Personality Disorders

Central Study Contacts

Michel WALTER

CONTACT

02-98-01-51-57; michel.walter@chu-brest.fr

Christophe LEMEY

CONTACT

christophe.lemey@chu-brest.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 26, 2018
• First Posted: May 15, 2018
• Study Start: May 18, 2018
• Primary Completion (Estimated): May 2, 2028
• Study Completion (Estimated): May 2, 2028
• Last Updated: September 26, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (3)