Use of Red Cell Distribution Width for Prediction of New-onset Atrial Fibrillation in Critically Ill Sepsis Patients

NCT03523676 | Completed

• 1 other identifier: R33 /2018
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

Red cell distribution width variations are increased in a variety of medical conditions such as congestive heart failure, acute myocardial infarction, pulmonary embolism, pneumonia, critical illness, and cardiac arrest , and is a predictor of mortality in the general population..

Conditions

Atrial Fibrillation New Onset

Outcome Measures

Primary Outcomes (1)

• New-Onset atrial fibrillation , confirmed by electrocardiographical assessment

  7 days

Study Arms (2)

Group A

sepsis patients who did not develop atrial fibrillation during ICU stay

Diagnostic Test: Red Cell Distribution Width

Group B

sepsis patients with newly developed atrial fibrillation during ICU stay

Diagnostic Test: Red Cell Distribution Width

Interventions

Red Cell Distribution Width DIAGNOSTIC_TEST

Group A; Group B

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

70 patients of both sexes were enrolled in this study. They were admitted to the general ICU of Ain Shams University Hospitals with sepsis or septic shock

You may qualify if:

• For all patients According to Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) , adult patients with suspected infection are identified, having quickSOFA (qSOFA) score meeting ≥2 of the following criteria: respiratory rate of 22/min or greater, altered mentation, or systolic blood pressure of 100 mmHg or less
• Sepsis patients with newly developed Atrial fibrillation during ICU stay.

You may not qualify if:

• All patients with concomitant valvular disease, cardiomyopathy, cardiac dysrhythmias, previous cardiac surgery, secondary hypertension, hyperthyroidism, severe head injury, stroke, coma, acute coronary artery disease or underlying cardiac dysfunction\[cardiac index (CI) \<2.2 l/min/m 2 \], severe liver disease (Child-Pugh grade C), chronic renal failure were excluded from the study. In addition, pregnant patients were excluded.

Sponsors & Collaborators

• Ain Shams University: lead

MeSH Terms

Interventions

Erythrocyte Indices

Intervention Hierarchy (Ancestors)

Hematologic Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Blood Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Officials

• Diaaeldein Ibrahim, MD

  Ain Shams University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical researcher

Study Record Dates

• First Submitted: May 2, 2018
• First Posted: May 14, 2018
• Study Start: January 1, 2017
• Primary Completion: January 1, 2018
• Study Completion: March 10, 2018
• Last Updated: May 14, 2018

Record last verified: 2018-05