Radiotherapy-Associated Atrial Fibrillation

NCT05927246 | Completed

• 1 other identifier: COEXIST-1
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

Radiotherapy associated Atrial Fibrillation (RADAF) is an observational study to evaluate onset time and frequency of atrial fibrillation in patients with thoracic malignancies and breast cancer. Each patient will have 12 lead ECG prior, and daily during radiotherapy.

Conditions

Atrial Fibrillation New Onset

Keywords

Atrial fibrillation; breast cancer; lung cancer; thoracic malignancies; cardiotoxicity

Outcome Measures

Primary Outcomes (2)

• Occurrence of atrial fibrillation

  Occurrence of atrial fibrillation

  1 day During radiotherapy

• Onset time of atrial fibrillation

  Onset time of atrial fibrillation

  1 day During radiotherapy

Study Arms (2)

Patients with Thoracic Malignancies

All patients undergoing RT for Thoracic Malignancies

Diagnostic Test: ECG

Patients with Breast Cancer

All patients undergoing RT for Breast Cancer

Diagnostic Test: ECG

Interventions

ECG DIAGNOSTIC_TEST

12 lead ecg for each participant

Patients with Breast Cancer; Patients with Thoracic Malignancies

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with breast and thoracic cancers will be evaluated for incidence and onset time of AFib.

You may qualify if:

• Patients with radiotherapy for thoracic malignancy or breast cancer
• Between 18-99 years-old

You may not qualify if:

• Patients with history of radiotherapy
• Patients with history of atrial fibrillation
• Patients with pacemaker implantation

Sponsors & Collaborators

• Istanbul University: lead

Study Sites (1)

Istanbul Faculty of Medicine

Fatih, Istanbul, 34093, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Atrial Fibrillation; Breast Neoplasms; Lung Neoplasms; Cardiotoxicity

Interventions

Electrocardiography

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Respiratory Tract Neoplasms; Thoracic Neoplasms; Lung Diseases; Respiratory Tract Diseases; Drug-Related Side Effects and Adverse Reactions; Chemically-Induced Disorders; Radiation Injuries; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis

Study Officials

• Cafer Zorkun, MD PhD

  Faculty member

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head, Division of CardioOncology

Study Record Dates

• First Submitted: June 23, 2023
• First Posted: July 3, 2023
• Study Start: January 1, 2023
• Primary Completion: June 1, 2023
• Study Completion: June 1, 2023
• Last Updated: July 3, 2023

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)