Oxidation-reduction Homeostasis in Cognitive Impairment Patients After Stroke

NCT03519828 | Completed

• 1 other identifier: k(2017)34
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Cognitive impairment after ischemic stroke can affect not only the social adaptation ability, but also affect the comprehensive rehabilitation of patients. The damage of cognitive impairment after ischemic stroke is not lower than the body function defect after stroke. Many studies have shown that oxidative stress is one of the pathophysiological mechanisms of ischemic cerebrovascular disease. Many studies have reported that the oxidative-reduction of cells plays an important role in the life activities of organisms, affecting the health, aging and death of the organism. In the recent years, some scholars have suggested that post-stroke cognitive impairment may be related to oxidative-reduction homeostasis of the body, but the relevant evidence is lacking and needs to be further explored. Therefore, the purpose of this study is to explore the effect of oxidation-reduction homeostasis on cognitive impairment in patients with ischemic stroke, and provide a theoretical basis for the prevention and treatment of cognitive impairment after ischemic stroke.

Conditions

Oxidative-reduction Homeostasis; Post-stroke Cognitive Impairment

Outcome Measures

Primary Outcomes (2)

• Oxidative-reduction homeostasis in acute ischemic stroke patients

  Reduced glutathione (GSH)/ Oxidized glutathione (GSSG), Superoxide dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GSH-PX) of acute ischemic stroke patients will be tested.

  1 day

• Cognitive function in acute ischemic stroke patients

  Mini Mental Status Examination (MMSE) and Montreal cognitive assessment scale (MoCA) in acute ischemic stroke patients will be evaluated.

  1 day

Study Arms (2)

Patients with post-stroke cognitive impairment

Other: No intervention has been conducted

Patients without post-stroke cognitive impairment

Other: No intervention has been conducted

Interventions

No intervention has been conducted OTHER

It is an observational study, and no intervention has been conducted

Patients with post-stroke cognitive impairment; Patients without post-stroke cognitive impairment

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Acute ischemic stroke patients in hospital from March, 2018 to September, 2018.

You may qualify if:

• years old;
• Ischemic stroke for the first time or previous stroke but with no serious sequelae (mRS is 0 -2 points);
• Time from onset to treatment ≤48 hours;
• Conscious awareness, and with no obvious aphasia and visual impairment;
• Signed informed consent by patient self or legally authorized representatives.

You may not qualify if:

• Intracranial hemorrhage or suspected subarachnoid hemorrhage;
• Transient ischemic attack;
• Patients with severe mental disorders or language disorders;
• Patients can not cooperate with evaluators, such as mental illness or dementia;
• Pregnant women or suckers;
• Researchers consider patients inappropriate to participate in the registry.

Sponsors & Collaborators

• Hui-Sheng Chen: lead

Study Sites (1)

General Hospital of ShenYang Military Region

Shenyang, Liaoning, 10016, China

Location

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 15, 2018
• First Posted: May 9, 2018
• Study Start: March 1, 2018
• Primary Completion: December 30, 2018
• Study Completion: January 1, 2019
• Last Updated: July 31, 2019

Record last verified: 2019-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)