NCT03518086

Brief Summary

The purpose of this study is to evaluate the safety and efficacy of Mirikizumab in participants with moderately to severely active ulcerative colitis (UC) who have had an inadequate response to, loss of response, or intolerant to conventional or biologic therapy for UC.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
1,281

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Jun 2018

Longer than P75 for phase_3

Geographic Reach
34 countries

498 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 4, 2018

Completed
4 days until next milestone

First Posted

Study publicly available on registry

May 8, 2018

Completed
1 month until next milestone

Study Start

First participant enrolled

June 18, 2018

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 21, 2021

Completed
1.1 years until next milestone

Results Posted

Study results publicly available

February 28, 2022

Completed
2.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

May 15, 2024

Completed
Last Updated

May 31, 2025

Status Verified

May 1, 2025

Enrollment Period

2.6 years

First QC Date

May 4, 2018

Results QC Date

January 26, 2022

Last Update Submit

May 14, 2025

Conditions

Keywords

Interleukin-23 (IL-23) antibodyIL-23p19

Outcome Measures

Primary Outcomes (1)

  • Percentage of Participants With Clinical Remission at Week 12

    Clinical remission at week 12 is defined as achieving a modified Mayo score (MMS) subscore for rectal bleeding=0, stool frequency=0 or 1 with ≥ 1 point decrease from baseline, and endoscopy=0 or 1 (excluding friability), excluding consideration of Physician's Global Assessment (PGA). Stool frequency subscore, based on the participant's diary and scored from 0 (normal number of stools) to 3 (5 or more stools than normal); Rectal bleeding subscore, based on the participant's diary and scored from 0 (no blood seen) to 3 (blood alone passed); Endoscopy subscore, based on colonoscopy or sigmoidoscopy and scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration). The confidence interval of 99.88% was chosen to match the significance level.

    Week 12

Secondary Outcomes (10)

  • Percentage of Participants With Clinical Response at Week 12

    Week 12

  • Percentage of Participants With Endoscopic Remission at Week 12

    Week 12

  • Percentage of Participants With Symptomatic Remission at Week 12

    Week 12

  • Percentage of Participants With Symptomatic Response at Week 12

    Week 12

  • Percentage of Participants With Histologic Remission at Week 12

    Week 12

  • +5 more secondary outcomes

Study Arms (4)

Placebo Intravenous (IV) Every 4 Weeks (Q4W)

PLACEBO COMPARATOR

Placebo given as an IV infusion Q4W on Weeks 0, 4, 8 for 12 weeks.

Drug: Placebo

300 Milligram (mg) Mirikizumab IV Q4W

EXPERIMENTAL

300 mg mirikizumab given as an IV infusion Q4W on Weeks 0, 4, 8 for 12 weeks.

Drug: Mirikizumab

Placebo IV Q4W Maximum Extended Enrollment (ME2)

PLACEBO COMPARATOR

Placebo given as an IV infusion Q4W on Weeks 0, 4, 8 for 12 weeks.

Drug: Placebo

300 mg Mirikizumab IV Q4W ME2

EXPERIMENTAL

300 mg mirikizumab given as an IV infusion Q4W on Weeks 0, 4, 8 for 12 weeks.

Drug: Mirikizumab

Interventions

Administered IV

Also known as: LY3074828
300 Milligram (mg) Mirikizumab IV Q4W300 mg Mirikizumab IV Q4W ME2

Administered IV

Placebo IV Q4W Maximum Extended Enrollment (ME2)Placebo Intravenous (IV) Every 4 Weeks (Q4W)

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Diagnosis of UC for at least 3 months prior to baseline.
  • Confirmed diagnosis of moderately or severely active UC, as assessed by the modified Mayo score (MMS).
  • Demonstrated an inadequate response to, a loss of response to, or an intolerance to conventional or to biologic therapy for UC.
  • If female, must meet the contraception requirements.

You may not qualify if:

  • Participants with a current diagnosis of Crohn's disease or inflammatory bowel disease-unclassified (indeterminate colitis).
  • Participants with a previous colectomy.
  • Participants with current evidence of toxic megacolon.
  • Prior exposure to anti-IL12p40 antibodies (e.g. ustekinumab) or anti-IL-23p19 antibodies (e.g. risankizumab, brazikumab, guselkumab or tildrakizumab).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (502)

Digestive Health Specialists of the Southeast

Dothan, Alabama, 36305, United States

Location

Dcr-Pi, Pc

Litchfield Park, Arizona, 85340, United States

Location

Maricopa Integrated Health System

Phoenix, Arizona, 85008, United States

Location

Physicians Research Group

Tempe, Arizona, 85284, United States

Location

Yuma Gastro LLC

Yuma, Arizona, 85364, United States

Location

Valley Gastroenterology

Arcadia, California, 91006, United States

Location

Care Access Research

Berkeley, California, 94705, United States

Location

Citrus Valley Health Partners

Covina, California, 91722, United States

Location

Valley View Internal Medicine

Garden Grove, California, 92843, United States

Location

Om Research, LLC

Lancaster, California, 93534, United States

Location

Catalina Research Institute, LLC

Montclair, California, 91763, United States

Location

California Medical Research Associates

Northridge, California, 91324, United States

Location

Gastroenterology Associates

Pasadena, California, 91105, United States

Location

Clinical Applications Laboratories, Inc.

San Diego, California, 92103, United States

Location

UCSF Medical Center at Mission Bay

San Francisco, California, 94158, United States

Location

University of Colorado

Aurora, Colorado, 80045, United States

Location

Delta Waves Sleep Disorders and Research Center

Colorado Springs, Colorado, 80918, United States

Location

Gastroenterology Consultants of Clearwater

Clearwater, Florida, 33756, United States

Location

West Central Gastroenterology d/b/a Gastro Florida

Clearwater, Florida, 33761, United States

Location

Clinical Research of West Florida, Inc. (Clearwater)

Clearwater, Florida, 33765, United States

Location

Pioneer Clinical Research

Coral Springs, Florida, 33067, United States

Location

Direct Helpers Medical Center

Hialeah, Florida, 33012, United States

Location

The Center for Gastrointestinal Disorders

Hollywood, Florida, 33021, United States

Location

Nature Coast Clinical Research, LLC

Inverness, Florida, 34452, United States

Location

SIH Research, LLC

Kissimmee, Florida, 34741, United States

Location

Columbus Clinical Services, LLC

Miami, Florida, 33125, United States

Location

Research Associates of South Florida, LLC

Miami, Florida, 33134, United States

Location

IMIC, Inc.

Miami, Florida, 33176, United States

Location

Inpatient Research Clinic, LLC

Miami Lakes, Florida, 33014, United States

Location

Life Medical Center & Research, Inc

Miami Lakes, Florida, 33014, United States

Location

Wellness Clinical Research

Miami Lakes, Florida, 33016, United States

Location

Pharma Research International, Inc.

Naples, Florida, 34110, United States

Location

Center for Interventional Endoscopy

Orlando, Florida, 32803, United States

Location

Clintheory Healthcare

Orlando, Florida, 32818, United States

Location

Gastroenterology Associates of Pensacola, PA

Pensacola, Florida, 32503, United States

Location

Florida Digestive Specialist

St. Petersburg, Florida, 33709, United States

Location

Florida Medical Clinic LLC

Zephyrhills, Florida, 33542-7505, United States

Location

Digestive Healthcare of Georgia

Atlanta, Georgia, 30309, United States

Location

Gastrointestinal Diseases Research

Columbus, Georgia, 31904, United States

Location

Atlanta Gastroenterology Specialists, PC

Suwanee, Georgia, 30024, United States

Location

Grand Teton Research Group

Idaho Falls, Idaho, 83404, United States

Location

NorthShore University HealthSystem

Evanston, Illinois, 60201, United States

Location

Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States

Location

Iowa Digestive Disease Center

Clive, Iowa, 50325, United States

Location

Cotton-O'Neil Clinical Research Center, Digestive Health

Topeka, Kansas, 66606, United States

Location

Texas Digestive Disease Consultants

Baton Rouge, Louisiana, 70809, United States

Location

Clinical Trials of SWLA, LLC

Lake Charles, Louisiana, 70601, United States

Location

Delta Research Partners LLC

Monroe, Louisiana, 71201, United States

Location

Tulane Univ School of Med

New Orleans, Louisiana, 70112 2715, United States

Location

Nola Research Works, LLC

New Orleans, Louisiana, 70125, United States

Location

Clinical Research Institute of Michigan, LLC

Chesterfield, Michigan, 48047, United States

Location

Henry Ford Health System

Novi, Michigan, 48377, United States

Location

Gastroenterology Associates of Western Michigan, P.L.C.

Wyoming, Michigan, 49519, United States

Location

Huron Gastroenterology Associates

Ypsilanti, Michigan, 48197, United States

Location

MNGI Digestive Health - Plymouth Endoscopy Center & Clinic

Plymouth, Minnesota, 55446, United States

Location

Care Access Research LLC

Jackson, Mississippi, 39206, United States

Location

Digestive Health Specialists

Tupelo, Mississippi, 38801, United States

Location

Washington University Medical School

St Louis, Missouri, 63110, United States

Location

Capital Health Medical Center Hopewell

Pennington, New Jersey, 08534, United States

Location

Northwell Health

Great Neck, New York, 11021, United States

Location

NYU Langone Long Island Clinical Research Associates

Lake Success, New York, 11042, United States

Location

Weill Cornell Medical College

New York, New York, 10021, United States

Location

University of North Carolina

Chapel Hill, North Carolina, 27599, United States

Location

Carolina Digestive Diseases and Endoscopy Center

Greenville, North Carolina, 27834, United States

Location

Wake Forest University School of Medicine

Winston-Salem, North Carolina, 27157-1045, United States

Location

Trinity Health Center Medical Arts

Minot, North Dakota, 58701, United States

Location

META Medical Research Institute, LLC

Dayton, Ohio, 45432, United States

Location

Paramount Medical Research

Middleburg Heights, Ohio, 44130, United States

Location

Care Access Research - Youngstown

Poland, Ohio, 44514, United States

Location

Great Lakes Medical Research, LLC

Westlake, Ohio, 44145, United States

Location

Central Sooner Research

Norman, Oklahoma, 73071, United States

Location

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

Location

Digestive Disease Associates

Wyomissing, Pennsylvania, 19610, United States

Location

Ocean State Clinical Research Partners

Lincoln, Rhode Island, 02865, United States

Location

Invocare Clinical Research Center

Mauldin, South Carolina, 29662, United States

Location

Invocare Clinical Research Center

West Columbia, South Carolina, 29169, United States

Location

Midwest Medical Care

Sioux Falls, South Dakota, 57108, United States

Location

Gastro One

Germantown, Tennessee, 38138, United States

Location

Galen Medical Group

Hixson, Tennessee, 37343, United States

Location

Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

Location

University of Texas Medical Branch at Galveston

Galveston, Texas, 77555, United States

Location

Digestive Health Associates of Texas

Garland, Texas, 75044, United States

Location

Houston Methodist Research Ins

Houston, Texas, 77030, United States

Location

Biopharma Informatic, Inc.

Houston, Texas, 77043, United States

Location

Gastroenterology Research of San Antonio

San Antonio, Texas, 78229, United States

Location

Southern Star Research Institute, LLC

San Antonio, Texas, 78229, United States

Location

Bandera Family Health Care

San Antonio, Texas, 78249, United States

Location

Texas Digestive Disease Consultants

Southlake, Texas, 76092, United States

Location

GI and Liver Research, LLC

Webster, Texas, 77598, United States

Location

Care Access Research LLC - Salt Lake City

Ogden, Utah, 84403, United States

Location

Care Access Research LLC - Salt Lake City

Salt Lake City, Utah, 84124, United States

Location

Emeritas Research Group

Leesburg, Virginia, 20176, United States

Location

Blue Ridge Medical Research

Lynchburg, Virginia, 24502, United States

Location

The Gastroenterology Group, P.C.

Reston, Virginia, 20191, United States

Location

Carilion Clinic

Roanoke, Virginia, 24016, United States

Location

University of Washington Medical Center

Seattle, Washington, 98195-6424, United States

Location

Wisconsin Center for Advanced Research

Milwaukee, Wisconsin, 53215, United States

Location

Allegiance Research Specialists, LLC

Milwaukee, Wisconsin, 53226, United States

Location

Centro de Investigaciones Metabólicas (CINME)

CABA, Buenos Aires, C1027AAP, Argentina

Location

Mautalen Salud e Investigacion-Centro de Osteopatías Médicas

Ciudad Autonoma de Buenos Air, Buenos Aires, C1128AAF, Argentina

Location

CER Instituto Medico

Quilmes, Buenos Aires, B1878DVC, Argentina

Location

Instituto de Investigaciones Clinicas Quilmes

Quilmes, Buenos Aires, B1878GEG, Argentina

Location

Fundación de Estudios Clínicos

Rosario, Santa Fe Province, S2000DEJ, Argentina

Location

Centro de Investigaciones Médicas Tucuman

SAN M. de Tucuman, Tucumán Province, T4000AXL, Argentina

Location

C.I.C.E. 9 de Julio

San Miguel de Tucumán, Tucumán Province, 4000, Argentina

Location

Hospital Privado Centro Medico de Cordoba SA

Córdoba, X5016KEH, Argentina

Location

Princess Alexandra Hospital

Harlow, Essex, CM20 1QX, Australia

Location

John Hunter Hospital

Newcastle, New South Wales, 2305, Australia

Location

Coastal Digestive Health

Maroochydore, Queensland, 4558, Australia

Location

Mater University Hospital

South Brisbane, Queensland, 4101, Australia

Location

Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia

Location

Box Hill Hospital Outpatients

Box Hill, Victoria, 3128, Australia

Location

Melbourne Gastrointestinal Investigation Unit (MGIU)

Malvern, Victoria, 3144, Australia

Location

The Alfred Hospital

Melbourne, Victoria, 3004, Australia

Location

Northern Hospital

Melbourne, Victoria, 3076, Australia

Location

The Royal Melbourne Hospital

Parkville, Victoria, 3050, Australia

Location

Krankenhaus der Barmherzigen Schwestern Wien

Vienna, Vienna, 1060, Austria

Location

Medizinische Universität Innsbruck

Innsbruck, 6020, Austria

Location

Universitätsklinikum Salzburg

Salzburg, 5020, Austria

Location

Medical University of Vienna

Vienna, 1090, Austria

Location

Universitair Ziekenhuis Gent

Ghent, Oost-Vlaanderen, 9000, Belgium

Location

Centre Hospitalier de Wallonie Picarde - Site Notre Dame

Tournai, Wallonne, Région, 7500, Belgium

Location

AZ Klina

Brasschaat, 2930, Belgium

Location

AZ Groeninge

Kortrijk, 8500, Belgium

Location

Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg

Leuven, 3000, Belgium

Location

Gastroenterology and internal medicine research institute

Edmonton, Alberta, T5R 1W2, Canada

Location

The Gordon and Leslie Diamond Health Care Centre

Vancouver, British Columbia, V5Z 1M9, Canada

Location

GI Research Institute

Vancouver, British Columbia, V6Z 2K5, Canada

Location

PerCuro Clinical Research

Victoria, British Columbia, V8V 3M9, Canada

Location

Victoria Hospital

London, Ontario, N6A 4G5, Canada

Location

University of Western Ontario

London, Ontario, N6A 5G1, Canada

Location

Centre de santé et de services sociaux Champlain-Charles-Le Moyne

Greenfield Park, Quebec, J4V 2H1, Canada

Location

Hopital Maisonneure-Rosemount

Montreal, Quebec, H1T 2M4, Canada

Location

Inflammatory Bowel Disease Centre Montreal General Hospital - MUHC

Montreal, Quebec, H3G 1A4, Canada

Location

Anhui Provincial Hospital

Hefei, Anhui, 230000, China

Location

The First Affiliated Hospital of Anhui Medical University

HefeiCity, Anhui, 230022, China

Location

Beijing Friendship Hospital

Beijing, Beijing Municipality, 100050, China

Location

Xiangya Hospital Central South University

Kaifu District, Changsha City, 410008, China

Location

The Affiliated 2nd Hosp. of Third Military Med. Univ. of PLA

Chongqing, Chongqing Municipality, 400037, China

Location

The First Hospital Affiliated to AMU (Southwest Hospital)

Chongqing, Chongqing Municipality, 400038, China

Location

Fujian Province Hospital

Fuzhou, Fujian, 350001, China

Location

The First Affiliated Hospital Of Fujian Medical University

Fujian, Fuzhou, 350005, China

Location

The Sixth Affiliated Hospital, Sun Yat-Sen University

Guangzhou, Guangdong, 510655, China

Location

The University of Hong Kong-Shenzhen Hospital

Shenzhen, Guangdong, 518053, China

Location

Hainan General Hospital

Haikou, Hainan, 570311, China

Location

The Second Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450014, China

Location

Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, Hubei, 430022, China

Location

Renmin Hospital of Wuhan University

Wuhan, Hubei, 430060, China

Location

ZhuZhou Central Hospital

Zhuzhou, Hunan, 412007, China

Location

Changzhou No.2 People's Hospital

Changzhou, Jiangsu, 213003, China

Location

The Affiliated Drum Tower Hospital of Nanjing University

Nanjing, Jiangsu, 210008, China

Location

Jiangsu Province Hospital of Chinese Medicine

Nanjing, Jiangsu, 210029, China

Location

Jiangsu Province Hospital

Nanjing, Jiangsu, 210029, China

Location

Zhongda Hospital Southeast University

Nanjing, Jiangsu, 210029, China

Location

Nanjing Medical University - Nanjing Jiangning Hospital

Nanjing, Jiangsu, 211106, China

Location

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330006, China

Location

Jiangxi Pingxiang People's Hospital

Pingxiang, Jiangxi, 337055, China

Location

The First Hospital of Jilin University

Changchun, Jilin, 130021, China

Location

Jilin Central General Hospital

Jilin, Jilin, 132011, China

Location

The Second Hospital of Dalian Medical University

Dalian, Lianing, 116000, China

Location

Shengjing Hospital of China Medical University

Shenyang, Liaoning, 110004, China

Location

Shengjing Hospital of China Medical University

Shenyang, Liaoning, 110022, China

Location

Shandong Provincial Hospital

Jinan, Shandong, 250001, China

Location

Qilu Hospital of Shandong University

Jinan, Shandong, 250014, China

Location

Liaocheng People's hospital

Liaocheng, Shandong, 252000, China

Location

The Affiliated Hospital of Qingdao University

Qingdao, Shandong, 266000, China

Location

Taian City Central Hospital

Taian, Shandong, 271000, China

Location

Shanghai Jiaotong University School of Medicine Ruijin Hospital

Shanghai, Shanghai Municipality, 200025, China

Location

Renji Hospital Affliated to Shanghai Jiaotong University

Shanghai, Shanghai Municipality, 200127, China

Location

West China Hospital Sichuan University

Chengdu, Sichuan, 610041, China

Location

No.1 Hospital Affiliated to Xinjiang Medical University

Ürümqi, Urumchi, 830054, China

Location

Kunming Medical College Affiliated First Hospital

Kunming, Yunnan, 650032, China

Location

The First People's Hospital of Yunnan Province

Kunming, Yunnan, 650034, China

Location

The Second Affiliated Hospital of Zhejiang University School of Med

Hangzhou, Zhejiang, 310000, China

Location

First Affiliated Hosp of College of Med, Zhejiang University

Hangzhou, Zhejiang, 310003, China

Location

Sir Run Run Shaw Hospital

Hangzhou, Zhejiang, 310016, China

Location

The Second Affiliated Hospital YuYing Childens Hospital of Wenzhou Medical university

Wenzhou, Zhejiang, 325027, China

Location

Tongji Hospital of Tongji University

Wuhan, 430030, China

Location

University Hospital Center Osijek

Osijek, 31000, Croatia

Location

CHC Zagreb

Zagreb, 10000, Croatia

Location

Polyclinic Bonifarm

Zagreb, 10000, Croatia

Location

Vojenska nemocnice Brno

Brno, Brno-město, 636 00, Czechia

Location

Fakultni nemocnice Kralovske Vinohrady

Prague, Hl. M. Praha, 100 34, Czechia

Location

Hepato-gastroenterologie HK

Hradec Králové, Hradec Králové, 50012, Czechia

Location

Klinika ResTrial

Prague, Modrany, 14300, Czechia

Location

MUDr. Gregar, s.r.o.

Olomouc, Olomoucký kraj, 779 00, Czechia

Location

A-Shine

Pilsen, Plzeň-město, 301 00, Czechia

Location

Mediendo

Prague, Praha 8, 18600, Czechia

Location

Fakultni nemocnice u sv. Anny v Brne

Brno, 65691, Czechia

Location

PreventaMed, s.r.o.

Olomouc, 779, Czechia

Location

ISCARE Clinical Centre

Prague, 19000, Czechia

Location

Sydvestjysk Sygehus Esbjerg

Esbjerg, 6700, Denmark

Location

Herlev and Gentofte Hospital

Herlev, 2730, Denmark

Location

Zealand University Hospital Køge

Køge, 4600, Denmark

Location

Hopital de Hautepierre - Service d'Hépatogastroentérolgie

Strasbourg, Bas Rhin, 67098, France

Location

Hopital Saint-Louis

Paris, Cedex 10, 75475, France

Location

CHU Lille - Hôpital Claude Huriez

Lille, Nord, 59037, France

Location

Hopital Beaujon

Clichy, Paris, 92110, France

Location

Centre Hospitalier de Pau

Pau, Pyrénées-Atlantiques, 64046, France

Location

Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -

Pierre-Bénite, Rhone, 69495, France

Location

CHU Amiens Picardie-Site Sud - RDC Service Hépato gastro

Amiens, Somme, 80480, France

Location

CHU Tours - Hôpital Trousseau

Chambray-lès-Tours, 37170, France

Location

Assistance Publique Hôpitaux de Marseille - Hôpital Nord

Marseille, 13915, France

Location

Hopital Saint Eloi

Montpellier, 34295, France

Location

Hopital L'Archet 2

Nice, 06200, France

Location

CHU Bordeaux - Hôpital Haut-Lévêque

Pessac, 33604, France

Location

CHU de Poitiers- Service d'Hépato-gastro-entérologie,

Poitiers, 86021, France

Location

Robert Debre Hospital

Reims, 51092, France

Location

CHU de Saint Etienne Hopital Nord

Saint-Priest-en-Jarez, 42270, France

Location

CHRU Nancy Brabois - Hôpital d'Enfants

Vandœuvre-lès-Nancy, 54500, France

Location

Medizinische Hochschule Hanover

Hanover, Lower Saxony, 30625, Germany

Location

Gastro Campus Research GbR

Münster, North Rhine-Westphalia, 48159, Germany

Location

Haus der Gesundheit

Ludwigshafen am Rhein, Rhineland-Palatinate, 67067, Germany

Location

Studiengesellschaft BSF Unternehmergesellschaft

Halle, Saxony-Anhalt, 06108, Germany

Location

Universitätsklinikum Halle

Halle, Saxony-Anhalt, 06120, Germany

Location

Charité Campus Virchow-Klinikum

Berlin, 12203, Germany

Location

Krankenhaus Waldfriede

Berlin, 14163, Germany

Location

Staedisches Klinikum Brandenburg

Brandenburg, 14770, Germany

Location

HaFCED - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen

Hamburg, 20251, Germany

Location

Praxiszentrum Alte Maelzerei

Regensburg, 93053, Germany

Location

Internistische Praxisgemeinschaft

Weyhe, 28844, Germany

Location

DRC Gyogyszervizsgalo Kozpont Kft.

Balatonfüred, EU, 8230, Hungary

Location

Jávorszky Ödön Kórház

Vác, Pest County, 2600, Hungary

Location

Óbudai Egészségügyi Centrum

Budapest, 1036, Hungary

Location

Semmelweis Egyetem

Budapest, 1088, Hungary

Location

Debreceni Egyetem Klinikai Kozpont

Debrecen, 4032, Hungary

Location

Endomedix Diagnosztikai Központ - Miskolc

Miskolc, 3526, Hungary

Location

Karolina Korhaz-Rendelointezet

Mosonmagyaróvár, 9200, Hungary

Location

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika

Szeged, 6720, Hungary

Location

Clinfan Szolgaltato Kft.

Szekszárd, 7100, Hungary

Location

Centre for Liver Research & Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital & Research Centre

Hyderabad, Andhra Pradesh, 500058, India

Location

Institute of Digestive and Liver Diseases

Guwahati, Assam, 781 006, India

Location

Apollo Research and Innovations, Apollo Hospitals International Ltd

Gandhinagar, Gujarat, 382428, India

Location

Shree Giriraj Multispeciality Hospital

Rajkot, Gujarat, 360005, India

Location

Nirmal Hospital

Surat, Gujarat, 395002, India

Location

Bangalore Medical College and Research Institute

Bangalore, Karnataka, 560 002, India

Location

M S Ramaiah Medical College Hospital

Bangalore, Karnataka, 560054, India

Location

Lokmanya Hospital

Mumbai, Maharashtra, 400022, India

Location

Midas Multispecilaity Hopsital Pvt Ltd

Nagpur, Maharashtra, 440010, India

Location

Poona Medical Foundation. Ruby Hall Clinic

Pune, Maharashtra, 411 001, India

Location

K E M Hospital and Research Centre

Pune, Maharashtra, 411011, India

Location

Datta Meghe Institute of Medical Sciences (DU), Acharya Vinoba Bhave Rural Hospital

Wardha, Maharashtra, 442004, India

Location

Escorts Heart Institute and Research Centre Ltd

New Delhi, National Capital Territory of Delhi, 110 025, India

Location

Sir Ganga Ram Hospital

New Delhi, National Capital Territory of Delhi, 110060, India

Location

Dayanand Medical College and Hospital

Ludhiana, Punjab, 141001, India

Location

SR Kalla Memorial Gastro & General Hospital

Jaipur, Rajasthan, 302001, India

Location

Asian Institute of Gastroenterology

Hyderabad, Telangana, 500032, India

Location

King George Medical University

Lucknow, Uttar Pradesh, 226003, India

Location

Fortis Hospital

Noida, Uttar Pradesh, 201301, India

Location

SSKM Post Graduate Hospital

Kolkata, West Bengal, 700020, India

Location

Nil Ratan Sircar Medical College

Kolkata, West Bengal, 700073, India

Location

Gandhi Hospital

Telangana, 500003, India

Location

Beaumont Hospital, Dublin

Dublin, D9, Ireland

Location

Meir Medical Center

Kfar Saba, Central District, 4428164, Israel

Location

Shaare Zedek Medical Center

Bait Vagan, Jerusalem, 91031, Israel

Location

Soroka Medical Center - Pediatric Outpatient Clinic

Beersheba, 8410101, Israel

Location

Galilee Medical Center Department of Internal Medicine A

Nahariya, 2210001, Israel

Location

Chaim Sheba Medical Center

Ramat Gan, 5262100, Israel

Location

Kaplan Medical Center

Rehovot, 7610001, Israel

Location

Tel Aviv Sourasky Medical Center

Tel Aviv, 6423906, Israel

Location

King Fahad Medical City

Ẕerifin, 70300, Israel

Location

Presidio di Rho

Rho, Milano, 20017, Italy

Location

Istituto Clinico Humanitas

Rozzano, Milano, 20089, Italy

Location

Ospedale Sandro Pertini

Rome, Roma, 00157, Italy

Location

Azienda Ospedaliera Universitaria Policlinico Tor Vergata

Torre, Roma, 00133, Italy

Location

I.R.C.C.S Policlinico San Donato

San Donato Milanese (MI), San Donato Milanese (MI), 20097, Italy

Location

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)

Brescia, 25123, Italy

Location

Azienda ospedaliero-universitaria Mater Domini

Catanzaro, 88100, Italy

Location

Azienda Ospedaliera Universitaria Careggi

Florence, 50134, Italy

Location

Azienda Ospedaliero Universitaria San Martino

Genova, 16132, Italy

Location

Gastroenterology and Endoscopy Unit IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation

Milan, 20122, Italy

Location

Azienda Ospedaliera Universitaria Policlinico de Modena

Modena, 41124, Italy

Location

Azienda Ospedaliera Universitaria Pisana

Pisa, 56124, Italy

Location

Policlinico Gemelli - Università Cattolica del Sacro Cuore

Roma, 00168, Italy

Location

Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona Medicina Interna

Salerno, 84131, Italy

Location

Ospedale Mauriziano Umberto I

Torino, 10128, Italy

Location

Azienda Ospedaliero-Universitaria Santa Maria della Misericordia Gastroenterologia

Udine, 33100, Italy

Location

Aichi Medical University Hospital

Nagakute-shi, Aichi-ken, 480-1195, Japan

Location

Fujita Health University

Toyoake, Aichi-ken, 470-1192, Japan

Location

National Hospital Organization Hirosaki National Hospital

Hirosaki, Aomori, 036-8545, Japan

Location

Toho University Sakura Medical Center

Sakura, Chiba, 285-8741, Japan

Location

Kitakyushu Municipal Medical Center

Kitakyusyu-shi, Fukoka, 802-0077, Japan

Location

Fukuoka University Chikushi Hospital

Chikushino-shi, Fukuoka, 818 8502, Japan

Location

Yukinoseibokai St. Mary's Hospital

Kurume-shi, Fukuoka, 830 8543, Japan

Location

Hidaka Coloproctology Clinic

Kurume-shi, Fukuoka, 839 0809, Japan

Location

Gunma University Hosptial

Maebashi, Gunma, 371-8511, Japan

Location

National Hospital Organization Takasaki General Medical Centar

Takasaki, Gunma, 370-0829, Japan

Location

NHO Mito Medical Center

Ibaraki-machi, HigaShiibaraki-Gun, 311 3193, Japan

Location

Hiroshima University Hospital

Hiroshima, Hiroshima, 734-8551, Japan

Location

Asahikawa City Hospital

Asahikawa, Hokkaido, 070-8610, Japan

Location

Tokushukai Sapporo Tokushukai Hospital

Sapporo, Hokkaido, 004 0041, Japan

Location

Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital

Sapporo, Hokkaido, 060 0033, Japan

Location

Sapporo Higashi Tokushukai Hospital

Sapporo, Hokkaido, 065-0033, Japan

Location

Aoyama Clinic GI Endoscopy & IBD Center

Kobe, Hyōgo, 650 0015, Japan

Location

Takamatsu Red Cross Hospital

Takamatsu, Kagawa-ken, 760-0017, Japan

Location

Kagawa Prefectural Central Hospital

Takamatsu, Kagawa-ken, 760-8557, Japan

Location

Ofuna Central Hospital

Kamakura, Kanagawa, 247-0056, Japan

Location

Kawasaki Municipal Hospital

Kawasaki, Kanagawa, 210-0013, Japan

Location

Kitasato University Hospital

Sagamihara, Kanagawa, 252-0375, Japan

Location

Sankikai Yokohama Shin midori General Hospital

Yokohama, Kanagawa, 226 0025, Japan

Location

Yokohama City University Medical Center

Yokohama, Kanagawa, 232-0024, Japan

Location

Showa University Northern Yokohama Hospital

Yokohama, Kanagawa, 234-0032, Japan

Location

Kumamoto University Hospital

Kumamoto, Kumamoto, 860-0012, Japan

Location

Mie University Hospital

Tsu, Mie-ken, 514-8507, Japan

Location

Takagi Clinic - Sendai

Sendai, Miyagi, 981 3213, Japan

Location

Nagaoka Chuo General Hospital

Nagaoka-shi, Niigata, 940-8653, Japan

Location

Ishida Clinic of IBD and Gastroenterology

Ōita, Oita Prefecture, 870 0823, Japan

Location

Sai Gastroenterology, proctology

Fujiidera, Osaka, 583-0027, Japan

Location

NHO Osaka National Hospital

Osaka, Osaka, 540 0006, Japan

Location

Osaka University Hospital

Suita, Osaka, 565-0871, Japan

Location

Saga-Ken Medical Center Koseikan

Saga, Saga-ken, 840-8571, Japan

Location

Kumagaya General Hospital

Kumagaya-shi, Saitama, 360-8567, Japan

Location

Matsuda Hospital

Hamamatsu, Shizuoka, 4328061, Japan

Location

Jichi Medical University Hospital

Shimotsuke-shi, Tochigi, 329-0498, Japan

Location

Juntendo University Hospital

Bunkyo-ku, Tokyo, 113-8431, Japan

Location

Tokyo Medical And Dental University Medical Hospital

Bunkyō, Tokyo, 113-8519, Japan

Location

Showa University Koto Toyosu Hospital

Koto-ku, Tokyo, 135 8577, Japan

Location

Kitasato University Kitasato Institute Hospital

Minato-Ku, Tokyo, 108 8642, Japan

Location

Kyorin University Hospital

Mitaka, Tokyo, 181-8611, Japan

Location

JHCO Tokyo Yamate Medical Center

Shinjuku-ku, Tokyo, 169-0073, Japan

Location

Mitsui Memorial Hospital

Chiyoda-ku, Tokyo-To, 101-8643, Japan

Location

Center Hospital of the National Center for Global Health and Medicine

Shinjuku-ku, Tokyo-To, 162 8655, Japan

Location

Fukuoka University Hospital

Fukuoka, 814-0180, Japan

Location

Sameshima Hospital

Kagoshima, 892-0846, Japan

Location

National Hospital Organization Kyoto Medical Center

Kyoto, 612-8555, Japan

Location

Okayama University Hospital

Okayama, 700-8558, Japan

Location

Infusion Clinic

Osaka, 530-0011, Japan

Location

Tokitokai Tokito Clinic

Saitama, 336 0963, Japan

Location

Toyama Prefectural Central Hospital

Toyama, 930-8550, Japan

Location

Pauls Stradins Clinical Univeristy Hospital

Riga, Rīga, LV-1002, Latvia

Location

Digestive Diseases Center "Gastro"

Riga, 1079, Latvia

Location

Riga Eastern Clinical University Hospital

Riga, LV-1038, Latvia

Location

Respublikine Panevezio Ligonine

Panevezys, Panevėžys, LT-35144, Lithuania

Location

Hospital of Lithuanian University of Health Sciences Kaunas

Kaunas, 50009, Lithuania

Location

Republic Hospital of Klaipeda

Klaipėda, 92231, Lithuania

Location

Klaipeda Seamen's Hospital

Klaipėda, 92288, Lithuania

Location

Vilnius University Hospital Santariskiu Clinics

Vilnius, LT-08661, Lithuania

Location

Hospital Sultanah Bahiyah

Alor Star, Kedah, 05460, Malaysia

Location

Universiti Sains Malaysia

Kubang Kerian, Kelantan, 16150, Malaysia

Location

University Malaya Medical Centre

Lembah Pantai, Kuala Lumpur, 59100, Malaysia

Location

Hospital Pulau Pinang

George Town, Pulau Pinang, 10450, Malaysia

Location

Hospital Ampang

Ampang, Selangor, 68000, Malaysia

Location

Clinical Research Institute S C

Tlalnepantla, Edo de Mex, 54055, Mexico

Location

Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.

Zapopan, Jalisco, 45030, Mexico

Location

Clinicos Asociados BOCM, S.C.

Mexico City, Mexico City, 03300, Mexico

Location

Centro de Investigación Clínica Acelerada

Mexico City, Mexico City, 07020, Mexico

Location

Centro Para el Desarrollo de la Medicina y de Asistencia Med S.C

Culiacán, Sinaloa, 80230, Mexico

Location

Scientia Investigacion Clinica S.C.

Chihuahua City, 31203, Mexico

Location

Sociedad de Metabolismo y Corazon

Veracruz, 91900, Mexico

Location

St Elisabeth Ziekenhuis

Tilburg, North Brabant, 5022 GC, Netherlands

Location

Amsterdam UMC, locatie AMC

Amsterdam, North Holland, 1105 AZ, Netherlands

Location

Bernhoven Ziekenhuis

Uden, 5406 PT, Netherlands

Location

UMC Utrecht, Dept. of Internal Medicine, MDL

Utrecht, 3584 CX, Netherlands

Location

Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland

Location

Centrum Medyczne Pratia Bydgoszcz

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland

Location

Topolowa Medicenter

Krakow, Lesser Poland Voivodeship, 31-506, Poland

Location

Medicenter Nowy Targ

Nowy Targ, Lesser Poland Voivodeship, 34-400, Poland

Location

Nzoz Formed

Wadowice, Lesser Poland Voivodeship, 34-100, Poland

Location

LexMedica

Wroclaw, Lower Silesian Voivodeship, 53-114, Poland

Location

ZOZ Gastromed

Lublin, Lublin Voivodeship, 20-582, Poland

Location

Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie

Lublin, Lublin Voivodeship, 20-954, Poland

Location

NZOZ Vivamed

Warsaw, Masovian Voivodeship, 03-580, Poland

Location

Endoskopia sp z o. o

Sopot, Pomeranian Voivodeship, 81-756, Poland

Location

SONOMED Centrum Medyczne

Szczecin, West Pomeranian Voivodeship, 71-685, Poland

Location

Promedica Dental Clinic

Będzin, 42-500, Poland

Location

All-Medicus

Katowice, 40-660, Poland

Location

Indywidualna Specjalistyczna Praktyka Lekarska

Knurów, 44-190, Poland

Location

Wojewodzki Specjalistyczny Szpital w Olsztynie

Olsztyn, 10-561, Poland

Location

Twoja Przychodnia-Szczecinskie Centrum Medyczne

Szczecin, 71-434, Poland

Location

Gastromed Kopoń Zmudziński I Wspólnicy Spółka Jawna Specjalistyczne Centrum Gastrologii I Endoskopii

Torun, 87-100, Poland

Location

Warsaw IBD Point Profesor Kierkus

Warsaw, 00-728, Poland

Location

Centrum Zdrowia MDM

Warsaw, 00635, Poland

Location

Centrum Medyczne NeuroProtect

Warsaw, 01-697, Poland

Location

Centralny Szpital Kliniczny MSWiA

Warsaw, 02-507, Poland

Location

PlanetMed Sp.z o.o.

Wroclaw, 52-210, Poland

Location

ETG Zamosc

Zamość, 22-400, Poland

Location

KO-Med Centrum Medyczne

Staszów, Świętokrzyskie Voivodeship, 28-200, Poland

Location

CCBR Clinical Research

Bucharest, București, 030463, Romania

Location

MedLife Grivita

Bucharest, 010719, Romania

Location

Spitalul Clinic Colentina

Bucharest, 020125, Romania

Location

Institutul Clinic Fundeni

Bucharest, 022328, Romania

Location

Hifu Terramed Conformal SRL

Bucharest, 031864, Romania

Location

Centrul Medical Unirea SRL

Bucharest, 040055, Romania

Location

Spital Pelican Oradea

Oradea, 410469, Romania

Location

Scientific Centre of Reconstructive and Restorative Surgery

Irkutsk, Irkutsk Oblast, 664079, Russia

Location

Karelia Republican Hospital V.A. Baranova

Petrozavodsk, Kareliya, Respublika, 185019, Russia

Location

Nizhny Novgorod Regional Hospital N.A. Semashko

Nizhny Novgorod, Nizhny Novgorod Oblast, 603126, Russia

Location

Private Healthcare Institution Clinical Hospital Russian Railways - Medicine of Nizhniy Novgorod

Nizhny Novgorod, Nizhny Novgorod Oblast, 603140, Russia

Location

Novosibirsk GastroCenter

Novosibirsk, Novosibirsk Oblast, 630007, Russia

Location

Rostov State Medical University

Rostov-on-Don, Rostov Oblast, 344091, Russia

Location

Scientific research center ECO-security

Saint Petersburg, Sankt-Peterburg, 196143, Russia

Location

Multidisciplinary Medical Clinic "Anthurium"

Barnaul, 656043, Russia

Location

Medical and Sanitary Division of Severstal

Cherepovets, 162600, Russia

Location

Alliance Biomedical URAL Group

Izhevsk, 426061, Russia

Location

Clinical Trials Center of Medical Institute

Kaliningrad, 236035, Russia

Location

State Autonomous Institution of Healthcare "Republican Clinical Hospital of the Ministry of Healthcare of Republic Tatarstan"

Kazan', 420064, Russia

Location

SIH Kemerovo Regional Clinical Hosptial

Kemerovo, 650066, Russia

Location

SBHI Regional Clinical Hospital #2 MoH of Krasnodar region

Krasnodar, 350000, Russia

Location

Medical rehabilitation center

Moscow, 125367, Russia

Location

LLC "Medicine Center SibNovoMed"

Novosibirsk, 630005, Russia

Location

Clinical Diagnostic Center Ultramed

Omsk, 644024, Russia

Location

City Mariinskaya Hospital

Saint Petersburg, 191104, Russia

Location

Pokrovskaya Municipal Hospital

Saint Petersburg, 195067, Russia

Location

Saint-Petersburg City Hospital of Saint Elizabeth

Saint Petersburg, 195257, Russia

Location

Non-state Healthcare Institution "Roadway Clinical Hospital of OJSC Russian Railways"

Saint Petersburg, 195271, Russia

Location

Saint Petersburg State Medical University n.a. Pavlov I.P.

Saint Petersburg, 197022, Russia

Location

LLC Gastroenterology Centre Expert

Saint Petersburg, 197110, Russia

Location

SBIH City Clinical Hospital #31

Saint Petersburg, 197110, Russia

Location

OOO "OrKli"

Saint Petersburg, 199147, Russia

Location

Medical Institute REAVIZ

Samara, 443001, Russia

Location

Stavropol State Medical Academy

Stavropol, 355018, Russia

Location

SBI of Healthcare of Leningrad region "Clinical Interregional Hospital of Tosno

Tosno, 187000, Russia

Location

Yaroslavl Municipal HI Clinical Hospital #8

Yaroslavl, 150030, Russia

Location

LLC MA New Hospital

Yekaterinburg, 620109, Russia

Location

Zemun Medical Centre

Zemun, Beograd, 11080, Serbia

Location

University Medical Center "Bezanijska kosa"

Belgrade, NAP, 11080, Serbia

Location

Regional Hospital Dr Radivoj Simonovic Sombor

Sombor, Vojvodina, 25000, Serbia

Location

Sremska Mitrovica Health Centre

Sremska Mitrovica, Vojvodina, 22000, Serbia

Location

General Hospital "Djordje Joanovic"

Zrenjanin, Vojvodina, 23000, Serbia

Location

Clinical Hospital Center Zvezdara

Belgrade, 11000, Serbia

Location

Clinical Center Kragujevac Gastroenterohepatology Clinic

Kragujevac, 34000, Serbia

Location

Clinical Center Kragujevac

Kragujevac, 34000, Serbia

Location

General Hospital Uzice

Užice, 31000, Serbia

Location

KM Management

Nitra, Nitra Region, 94901, Slovakia

Location

Gastro

Prešov, Presov, 08001, Slovakia

Location

Endomed, s.r.o.

Vranov N. Toplou, Presov, 09301, Slovakia

Location

Alian, s.r.o.

Bardejov, Slovak Republic, 08501, Slovakia

Location

Fakultna nemocnica s poliklinikou Roosevelta Banska Bystrica

Banská Bystrica, 975 17, Slovakia

Location

Univerzitna nemocnica Bratislava-Nemocnica Stare Mesteo

Bratislava, 813 69, Slovakia

Location

Univerzitna nemocnica Bratislava

Bratislava, 82007, Slovakia

Location

Severance Hospital, Yonsei University Health System

Wŏnju, Gangwon-do, 26426, South Korea

Location

The Catholic University of Korea, St. Vincent's Hospital

Suwon, Gyeonggi-do, 16247, South Korea

Location

Kyung Hee University Hospital

Seoul, Korea, 02447, South Korea

Location

Asan Medical Center

Seoul, Korea, 05505, South Korea

Location

Dong-A University Hospital

Busan, Pusan-Kwangyǒkshi, 49201, South Korea

Location

Kangbuk Samsung Hospital

Seoul, Seoul-teukbyeolsi [Seoul], 03181, South Korea

Location

Samsung Medical Center

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea

Location

The Catholic University of Korea, Daejeon St. Mary's Hospital

Daejeon, Taejǒn-Kwangyǒkshi, 34943, South Korea

Location

Inje University Haeundae Paik Hospital

Busan, 48108, South Korea

Location

Kyungpook National University Medical Center Chilgok Hospital

Daegu, 41404, South Korea

Location

Yeungnam Univeristy Medical Center

Daegu, 42415, South Korea

Location

Hospital Universitario Virgen Del Rocio

Seville, Andalusia, 41013, Spain

Location

Hospital Universitari Son Espases

Palma de Mallorca, Baleares Islands, 07120, Spain

Location

Hospital Universitario Marques De Valdecilla

Santander, Cantabria, 39008, Spain

Location

Hospital De Fuenlabrada

Fuenlabrada, Madrid, 28942, Spain

Location

Complejo Hospitalario De Navarra

Pamplona, Navarre, 31008, Spain

Location

Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias, 3306, Spain

Location

Hospital de Sagunto y C.E.

Sagunto, Valencia, 46520, Spain

Location

Complexo Hospitalario Universitario A Coruña, CHUAC

A Coruña, 15006, Spain

Location

Instituto de Ciencias Médicas

Alicante, 03004, Spain

Location

Hospital Universitario Reina Sofia Comite Etico

Córdoba, 14004, Spain

Location

Hospital Universitari de Girona

Girona, 17007, Spain

Location

Hospital Universitario Juan Ramon Jimenez

Huelva, 21005, Spain

Location

Hospital De Gran Canaria Dr. Negrin

Las Palmas de Gran Canaria, 35010, Spain

Location

Hospital Universitario La Paz

Madrid, 28046, Spain

Location

Inselspital Bern

Bern, 3010, Switzerland

Location

Gastroenterologische Praxis Balsiger, Seibold & Partner

Bern, 3012, Switzerland

Location

Kantonsspital St.Gallen

Sankt Gallen, 9007, Switzerland

Location

Universitätsspital Zürich

Zurich, 8091, Switzerland

Location

Changhua Christian Hospital

Changhua, 500, Taiwan

Location

China Medical University Hospital

Taichung, 40447, Taiwan

Location

Health management center

Taipei, 10002, Taiwan

Location

Gazi University Faculty of Medicine

Beşevler, Ankara, 65600, Turkey (Türkiye)

Location

Hacettepe University Faculty of Medicine

Sihhiye, Ankara, 6100, Turkey (Türkiye)

Location

Antalya Egitim ve Arastırma Hastanesi

Kocaeli, Antayla, 7100, Turkey (Türkiye)

Location

Acibadem Universitesi - Acibadem Kozyatagi Hastanesi

Kadıköy, Istanbul, 34734, Turkey (Türkiye)

Location

Kocaeli University Medical Faculty Hospital

İzmit, Kocaeli, 41380, Turkey (Türkiye)

Location

Mersin University Medical Faculty

Yenişehir, Mersin, 33110, Turkey (Türkiye)

Location

Ege Universitesi Hastanesi

Izmir, 35100, Turkey (Türkiye)

Location

Ivano-Frankivsk Regional Clinical Hospital

Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76008, Ukraine

Location

City Clinical Hospital #2

Kharkiv, Kharkivs’ka Oblast’, 61037, Ukraine

Location

Kherson City Clinical Hospital

Kherson, Kherson Oblast, 73000, Ukraine

Location

Medical Center of Limited Liability Company "Medical Center "Consilium Medical"

Kiev, Kyiv Oblast, 04050, Ukraine

Location

Lviv Railway Clinical Hospital

Lviv, Lviv Oblast, 79000, Ukraine

Location

Lviv Regional Endocrinology Dispensary

Lviv, Lviv Oblast, 79000, Ukraine

Location

Municipal non-profit enterprise "Lviv Territorial Medical Union "Multidisciplinary Clinical Hospital of Em -T

Lviv, Lviv Oblast, 79000, Ukraine

Location

Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho

Poltava, Poltava Oblast, 36000, Ukraine

Location

Diaservis - Medical and Diagnostic Center

Zaporizhzhia, Zaporizhzhia Oblast, 69076, Ukraine

Location

Medical Center of Limited Liability Company Medical Center Clinic of Family Medicine

Dnipro, 49038, Ukraine

Location

Kharkiv City Student Hospital

Kharkiv, 61002, Ukraine

Location

GI L.T. Malaya TI Namsu

Kharkiv, 61039, Ukraine

Location

Treatment-Diagnostic Center of Private Enterprise of PPC Atsynus

Kropyvnytskyi, 25006, Ukraine

Location

Kyiv Municipal Clinical Hospital #1

Kyiv, 02091, Ukraine

Location

Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary"

Kyiv, 04078, Ukraine

Location

Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary"

Kyiv, 04107, Ukraine

Location

Communal Enterprise "Odesa Regional Clinical Hospital"

Odesa, 65000, Ukraine

Location

A. Novak Transcarpathian Regional Clinical Hospital

Uzhhorod, 88000, Ukraine

Location

Vinnytsia RCH of Veterans of War Dept of Therapy#1 Vinnytsia M.I.Pyrogov NMU

Vinnytsia, 21005, Ukraine

Location

MCIC MC LLC Health Clinic

Vinnytsia, 21009, Ukraine

Location

M.I. Pyrogov Regional Clinical Hospital

Vinnytsia, 21018, Ukraine

Location

CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM

Vinnytsia, 21029, Ukraine

Location

Private Small Enterprise, Medical Center Pulse

Vinnytsia, 21029, Ukraine

Location

Communal Institution of Kyiv Regional Council Kyiv Regional Hospital #2

Zaporizhzhia, 69104, Ukraine

Location

Queens Hospital

Romford, Essex, RM7 0AG, United Kingdom

Location

Fairfield General Hospital

Bury, Great Britain, BL9 7TD, United Kingdom

Location

Royal Hampshire County Hospital

Winchester, Hants, SO22 5DG, United Kingdom

Location

St Thomas' Hospital

Great Maze Pond, London, SE1 9RT, United Kingdom

Location

Ninewells Hospital

Dundee, Scotland, DD1 9SY, United Kingdom

Location

Whipps Cross University Hospital

London, Surrey, E11 1NR, United Kingdom

Location

Morriston Hospital

Swansea, Swansea [Abertawe Gb-ata], SA6 6SG, United Kingdom

Location

St James's University Hospital

Leeds, Vinnytsia, LS9 7TF, United Kingdom

Location

Queen Elizabeth University Hospital

Glasgow, G51 4TF, United Kingdom

Location

Related Publications (9)

  • Clemow DB, Dubinsky MC, Baygani SK, Sands BE, Keohane A, Danese S, Schreiber S, Walsh AJ, Hibi T, Gibble TH, Moses RE, Travis SPL. Bowel urgency in ulcerative colitis: effect of baseline urgency and change in urgency in response to mirikizumab. J Patient Rep Outcomes. 2025 Jul 1;9(1):75. doi: 10.1186/s41687-025-00906-0.

  • Panaccione R, Chan-Diehl F, Baygani S, Fisher DA, Moses RE, Siegmund B, Walsh A, Kobayashi T, Dulai PS, Travis S. Fecal Calprotectin and C-Reactive Protein Association With Histologic and Endoscopic Endpoints in Mirikizumab-Treated Patients With Ulcerative Colitis. Crohns Colitis 360. 2025 Jun 14;7(2):otaf043. doi: 10.1093/crocol/otaf043. eCollection 2025 Apr.

  • Sands BE, D'Haens G, Clemow DB, Irving PM, Johns JT, Gibble TH, Abreu MT, Lee SD, Hisamatsu T, Kobayashi T, Dubinsky MC, Vermeire S, Siegel CA, Peyrin-Biroulet L, Moses RE, Milata J, Panaccione R, Dignass A. Three-Year Efficacy and Safety of Mirikizumab Following 152 Weeks of Continuous Treatment for Ulcerative Colitis: Results From the LUCENT-3 Open-Label Extension Study. Inflamm Bowel Dis. 2025 Jul 7;31(7):1876-1890. doi: 10.1093/ibd/izae253.

  • Danese S, Dignass A, Matsuoka K, Ferrante M, Long M, Redondo I, Moses R, Maier S, Hunter Gibble T, Morris N, Milch C, Abreu MT. Early and Sustained Symptom Control with Mirikizumab in Patients with Ulcerative Colitis in the Phase 3 LUCENT Programme. J Crohns Colitis. 2024 Nov 4;18(11):1845-1856. doi: 10.1093/ecco-jcc/jjae088.

  • Long MD, Schreiber S, Hibi T, Gibble TH, Fisher DA, Park G, Moses RE, Higgins PDR, Lindsay JO, Lee SD, Escobar R, Jairath V. Association of Bowel Urgency With Quality-of-Life Measures in Patients With Moderately-to-Severely Active Ulcerative Colitis: Results From Phase 3 LUCENT-1 (Induction) and LUCENT-2 (Maintenance) Studies. Crohns Colitis 360. 2024 Jan 6;6(1):otae001. doi: 10.1093/crocol/otae001. eCollection 2024 Jan.

  • Sands BE, Feagan BG, Hunter Gibble T, Traxler KA, Morris N, Eastman WJ, Schreiber S, Jairath V, Long MD, Armuzzi A. Mirikizumab Improves Quality of Life in Patients With Moderately-to-Severely Active Ulcerative Colitis: Results From the Phase 3 LUCENT-1 Induction and LUCENT-2 Maintenance Studies. Crohns Colitis 360. 2023 Nov 7;5(4):otad070. doi: 10.1093/crocol/otad070. eCollection 2023 Oct.

  • Chua L, Friedrich S, Zhang XC. Mirikizumab Pharmacokinetics in Patients with Moderately to Severely Active Ulcerative Colitis: Results from Phase III LUCENT Studies. Clin Pharmacokinet. 2023 Oct;62(10):1479-1491. doi: 10.1007/s40262-023-01281-z. Epub 2023 Aug 23.

  • D'Haens G, Dubinsky M, Kobayashi T, Irving PM, Howaldt S, Pokrotnieks J, Krueger K, Laskowski J, Li X, Lissoos T, Milata J, Morris N, Arora V, Milch C, Sandborn W, Sands BE; LUCENT Study Group. Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis. N Engl J Med. 2023 Jun 29;388(26):2444-2455. doi: 10.1056/NEJMoa2207940.

  • Magro F, Pai RK, Kobayashi T, Jairath V, Rieder F, Redondo I, Lissoos T, Morris N, Shan M, Park M, Peyrin-Biroulet L. Resolving Histological Inflammation in Ulcerative Colitis With Mirikizumab in the LUCENT Induction and Maintenance Trial Programmes. J Crohns Colitis. 2023 Oct 20;17(9):1457-1470. doi: 10.1093/ecco-jcc/jjad050.

Related Links

MeSH Terms

Conditions

Colitis, Ulcerative

Interventions

mirikizumab

Condition Hierarchy (Ancestors)

ColitisGastroenteritisGastrointestinal DiseasesDigestive System DiseasesInflammatory Bowel DiseasesColonic DiseasesIntestinal Diseases

Results Point of Contact

Title
Chief Medical Officer
Organization
Eli Lilly and Company

Study Officials

  • Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

    Eli Lilly and Company

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
GT60
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 4, 2018

First Posted

May 8, 2018

Study Start

June 18, 2018

Primary Completion

January 21, 2021

Study Completion

May 15, 2024

Last Updated

May 31, 2025

Results First Posted

February 28, 2022

Record last verified: 2025-05

Data Sharing

IPD Sharing
Will share

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
Data are available 6 months after the primary publication and approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.
Access Criteria
A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.
More information

Locations