NCT03516890

Brief Summary

To investigate the best treatment for hepatocellular carcinoma rupture

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
216

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2005

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2005

Completed
10.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2015

Completed
2.5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2017

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

April 4, 2018

Completed
1 month until next milestone

First Posted

Study publicly available on registry

May 4, 2018

Completed
Last Updated

May 4, 2018

Status Verified

April 1, 2018

Enrollment Period

10.4 years

First QC Date

April 4, 2018

Last Update Submit

May 3, 2018

Conditions

Rupture, SpontaneousRupture LiverHepatocellular Carcinoma

Keywords

Partial hepatectomyEmergencyStagedPeritoneal disseminationPropensity score matching

Outcome Measures

Primary Outcomes (1)

  • Overall survival of all patients

    Overall survival difference between the partial hepatectomy group and the non-surgical group

    5 years

Secondary Outcomes (6)

  • Postoperative peritoneal dissemination

    5 years

  • Recurrence-free survival of all patients

    5 years

  • Overall survival of partial hepatectomy patients

    5 years

  • Recurrence-free survival of partial hepatectomy patients

    5 years

  • Overall survival of staged partial hepatectomy patients

    5 years

  • +1 more secondary outcomes

Interventions

Partial hepatectomyPROCEDURE

Partial hepatectomy was comprised of single or multiple liver resections aiming to excise all macroscopic tumors.

Eligibility Criteria

Age15 Years - 76 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

From January 2005 to June 2015, all patients complied with the criteria mentioned above who received partial hepatectomy or non-surgical at our center were included in this study.

You may qualify if:

  • Being diagnosed as hepatocellular carcinoma with tumor rupture; with complete data and without loss of follow-up

You may not qualify if:

  • Without complete data; with loss of follow-up; not hepatocellular carcinoma based on pathological diagnosis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Rupture, SpontaneousCarcinoma, HepatocellularEmergencies

Condition Hierarchy (Ancestors)

Pathological Conditions, AnatomicalPathological Conditions, Signs and SymptomsAdenocarcinomaCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasmsLiver NeoplasmsDigestive System NeoplasmsNeoplasms by SiteDigestive System DiseasesLiver DiseasesDisease AttributesPathologic Processes

Study Officials

  • Xiao-ping Chen, PHD

    Huazhong University of Science and Technology

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

April 4, 2018

First Posted

May 4, 2018

Study Start

January 1, 2005

Primary Completion

June 1, 2015

Study Completion

December 1, 2017

Last Updated

May 4, 2018

Record last verified: 2018-04