NCT03503903

Brief Summary

This study evaluates the efficacy of Wet cupping Therapy on oxidative stress and antioxidant capacity of the body.The healthy volunteers will receive wet cupping application and their initial venous blood samples and samples after the treatment will be evaluated for oxidative stress.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
24

participants targeted

Target at P25-P50 for not_applicable healthy

Timeline
Completed

Started Mar 2018

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2018

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

April 4, 2018

Completed
16 days until next milestone

First Posted

Study publicly available on registry

April 20, 2018

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 15, 2018

Completed
17 days until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2018

Completed
Last Updated

February 20, 2020

Status Verified

February 1, 2020

Enrollment Period

5 months

First QC Date

April 4, 2018

Last Update Submit

February 18, 2020

Conditions

Healthy

Keywords

Wet cupping therapyantioxidant capacity

Outcome Measures

Primary Outcomes (2)

  • TAS

    Total antioxidant status

    7 days

  • TOS

    Total oxidant status

    7 days

Secondary Outcomes (2)

  • SOD

    7 days

  • CAT

    7 days

Study Arms (1)

Wet Cupping

EXPERIMENTAL

One armed self-controlled study. Individuals in this arm will receive three concecutive WCT application

Procedure: Wet Cupping

Interventions

Wet CuppingPROCEDURE

CT was applied using plastic disposable vacuum cups on the back in the 5 areas of C7 cervical spine (DU14 acupoint), T2-4 lateral spine bilaterally (BL41-42 acupoint) and T6-8 lateral spine bilaterally (BL44-46), which are the recommended sites for headache (12). The cupping technique procedure was conducted in five phases:Primary suction,Area disinfection,Scarification,Secondary suction and bloodletting,Removing and dressing.

Wet Cupping

Eligibility Criteria

Age18 Years - 50 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy male adults
  • Must apply Traditional and complemantary medicine center for general well being.

You may not qualify if:

  • Any chronic disorder
  • Antiagregant drug usage
  • Bleeding disorders

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Karabuk University Karabuk Research and Education hospital

Karabük, Karabük Province, 78070, Turkey (Türkiye)

Location

Related Publications (6)

  • . Burton, M. Smith, T. Falkenberg, Building WHO's global strategy for traditional medicine, European Journal of Integrative Medicine 7(1) (2015) 13-15.

    BACKGROUND

  • M. Ahmedi, M.R. Siddiqui, The value of wet cupping as a therapy in modern medicine-An Islamic Perspective, (2014).

    BACKGROUND

  • S. El Sayed, H. Mahmoud, M. Nabo, Methods of wet cupping therapy (Al-Hijamah): in light of modern medicine and prophetic medicine, Alternative & Integrative Medicine (2013) 1-16.

    BACKGROUND

  • Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol. 1997 Mar;82(2):291-5. doi: 10.1113/expphysiol.1997.sp004024.

    PMID: 9129943BACKGROUND

  • Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006 Oct 19;443(7113):787-95. doi: 10.1038/nature05292.

    PMID: 17051205BACKGROUND

  • Ersoy S, Benli AR. Continue or stop applying wet cupping therapy (al-hijamah) in migraine headache:A randomized controlled trial. Complement Ther Clin Pract. 2020 Feb;38:101065. doi: 10.1016/j.ctcp.2019.101065. Epub 2019 Oct 18.

    PMID: 31668556DERIVED

Study Officials

  • SULEYMAN ERSOY

    Karabuk University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Asist.Prof. Department of Family Medicine

Study Record Dates

First Submitted

April 4, 2018

First Posted

April 20, 2018

Study Start

March 1, 2018

Primary Completion

July 15, 2018

Study Completion

August 1, 2018

Last Updated

February 20, 2020

Record last verified: 2020-02

Data Sharing

IPD Sharing
Will not share

Locations

TU(1)