Acute Effects of Inspiratory Muscle Training at Different Intensities in Healthy People

NCT03788356 | Completed

• 1 other identifier: 2018/14-16
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

At least 30 volunteers will be included in the study. After questioning the demographic and clinical information of the participants, dyspnea perception, respiratory functions, respiratory muscle strength, heart rate variability, arterial stiffness, and blood pressure and physical activity levels will be evaluated. Inspiratory muscle training will be done for 15 minutes with an electronic device. Respiratory training will be applied at three different concentrations with 10%, 30% and 60% of maximal inspiratory pressure. Heart rate variability, arterial stiffness, and blood pressure measurements will be repeated after inspiratory muscle training sessions at different intensities.

Conditions

Healthy

Outcome Measures

Primary Outcomes (4)

• Heart Rate

  The heart rate is the number of beats per minute of the heart. It represents both sympathetic and parasympathetic system activity. increased heart rate indicates that the sympathetic activity is dominant, while decreased heart rate indicates that parasympathetic activity is dominant.

  Change from Baseline at 15 minutes

• Augmentation Index

  Augmentation index is commonly used noninvasive measurements of wave reflection strength. To assess augmentation index, brachial artery compression waveforms were obtained by partially inflating a cuff over the brachial artery approximately midway between the shoulder and the elbow. The brachial waveforms were calibrated using cuff-measured brachial systolic and diastolic pressures, and then used to generate central aortic pressure waveforms by applying proprietary digital signal processing and transfer function. The central aortic pulse wave was used to determine augmentation index. High values represent abnormal wave reflection strength.

  Change from Baseline at 15 minutes

• Aortic Pulse Wave Velocity

  Aortic pulse wave velocity is commonly used noninvasive measurements of arterial stiffness. To assess aortic pulse wave velocity, carotid pulse waves were measured by applanation tonometry and femoral pulse waves were simultaneously obtained by a partially inflated cuff over the femoral artery at the leg midway between the hip and the knee. Aortic pulse wave velocity was determined by calculating the ratio of the corrected distance between the pulse measuring sites to the time delay between the carotid and femoral pulse waves. High values represent increased arterial stiffness.

  Change from Baseline at 15 minutes

• Square Root of The Mean Squared Difference of Successive Normal to Normal R-R Intervals

  Square Root of The Mean Squared Difference of Successive Normal to Normal R-R Intervals is one of the time domain methods of heart rate variability. It represents a primarily parasympathetic activity or vagal modulation. Low values indicate decreased parasympathetic activity. High values indicate increased parasympathetic activity.

  Change from Baseline at 15 minutes

Secondary Outcomes (16)

• Maximal inspiratory pressure

  At Baseline

• Maximal expiratory pressure

  At Baseline

• Blood pressure

  Change from Baseline at 15 minutes

• Forced vital capacity

  At Baseline

• Vital capacity

  At Baseline

Study Arms (4)

Diaphragmatic breathing

EXPERIMENTAL

Diaphragmatic breathing exercise for 15 minutes.

Other: Diaphragmatic breathing

10% inspiratory muscle training

EXPERIMENTAL

Inspiratory muscle training at 10% intensity of maximal inspiratory pressure for 15 minutes

Device: Inspiratory muscle training

30% inspiratory muscle training

EXPERIMENTAL

Inspiratory muscle training at 30% intensity of maximal inspiratory pressure for 15 minutes

Device: Inspiratory muscle training

60% inspiratory muscle training

EXPERIMENTAL

Inspiratory muscle training at 60% intensity of maximal inspiratory pressure for 15 minutes

Device: Inspiratory muscle training

Interventions

Inspiratory muscle training DEVICE

Inspiratory muscle training with a device

10% inspiratory muscle training; 30% inspiratory muscle training; 60% inspiratory muscle training

Diaphragmatic breathing OTHER

Diaphragmatic breathing exercise

Also known as: Exercise

Diaphragmatic breathing

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy People

You may not qualify if:

• Body mass index (BMI) \> 30 kg/m²
• Smoking
• The presence of exercise habit
• Medication use
• Neurological, cardiovascular or respiratory disorders

Sponsors & Collaborators

• Dokuz Eylul University: lead

Study Sites (1)

Dokuz Eylül University

Izmir, 35320, Turkey (Türkiye)

Location

Related Publications (1)

• Tanriverdi A, Kahraman BO, Ozsoy I, Ozpelit E, Savci S. Acute effects of inspiratory muscle training at different intensities in healthy young people. Ir J Med Sci. 2021 May;190(2):577-585. doi: 10.1007/s11845-020-02353-w. Epub 2020 Aug 26.

  PMID: 32851483 DERIVED

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 18, 2018
• First Posted: December 27, 2018
• Study Start: January 2, 2019
• Primary Completion: April 4, 2019
• Study Completion: April 4, 2019
• Last Updated: April 8, 2019

Record last verified: 2019-04

Locations

TU (1)