Metabolic Signatures of Dairy Products Ingestion in Humans: Effect of Age

NCT03500003 | Completed

• 1 other identifier: FermentoMilk
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

Despite the fact that dairy products are greatly consumed, it remains today very difficult to determine with a classical blood biochemical test whether a person has ingested a fresh fermented dairy product or just milk, while their biological, metabolic and health impacts may be different. The metabolic footprint left by the consumption of these products could be modified by the age of the consumer. Indeed, in the elderly, the processes of digestion, assimilation and metabolism are known to be altered /different compared to healthy adults. Thus, different metabolic signatures in the elderly could appear as the result of a less effective use and metabolism of the nutrients ingested. This could further also result in different or altered biological effects on dairy products.

Conditions

Nutrition

Keywords

dairy products; milk; yogurt; metabolomics; elderly

Outcome Measures

Primary Outcomes (1)

• Metabolomics: discovery of novel biomarkers of acute dairy intake (milk and yogurt)

  Analysis of the urine and plasma metabolome

  Baseline, then ten times during the 6h following product intake on two different days (one milk, one yogurt)

Secondary Outcomes (3)

• glucose homeostasis markers

  Baseline, then ten times during the 6h following product intake on two different days (one milk, one yogurt)

• lipid homeostasis markers

  Baseline, then ten times during the 6h following product intake on two different days (one milk, one yogurt)

• Inflammation markers

  Baseline, then ten times during the 6h following product intake on two different days (one milk, one yogurt)

Study Arms (2)

Milk acute intake

EXPERIMENTAL

14 adult and 14 elderly volunteers will consume 600mL of milk. Blood (11 sampling points) and urine samples (3 collection points) will be collected before the ingestion and during the postprandial period (6h).

Other: Acute milk intake

Yogurt acute intake

EXPERIMENTAL

14 adult and 14 elderly volunteers will consume 600mL of yogurt. Blood (11 sampling points) and urine samples (3 collection points) will be collected before the ingestion and during the postprandial period (6h).

Other: Acute Yogurt intake

Interventions

Acute milk intake OTHER

Food matrix: milk

Milk acute intake

Acute Yogurt intake OTHER

Food matrix: yogurt

Yogurt acute intake

Eligibility Criteria

• Age: 25 Years - 80 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• no pathology and no medical treatment
• BMI \>=21 and \<=30 kg/m²
• normal biological status
• no dislike for diary intake

You may not qualify if:

• smoking
• no pathology and no medical treatment (no antibiotics in the last 3 months)
• consumption of nutritional supplements several times at week

Sponsors & Collaborators

• Sergio Polakof: lead
• Centre de Recherche en Nutrition Humaine d'Auvergne: collaborator
• Agroscope Liebefeld-Posieux Research Station ALP: collaborator

Study Sites (1)

Centre de Recherche en Nutrition Humaine d'Auvergne

Clermont-Ferrand, 63000, France

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: March 27, 2018
• First Posted: April 17, 2018
• Study Start: June 1, 2018
• Primary Completion: August 6, 2019
• Study Completion: August 6, 2019
• Last Updated: August 7, 2019

Record last verified: 2019-08

Locations

FR (1)