The Effects of Unfiltered (Turkish) Coffee Consumption on Cardiovascular Risk Parameters

NCT03495336 | Completed DMC

• 1 other identifier: EasternMedU
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

Purpose/Objective: The aim of this study is to investigate the impact of boiled unfiltered (Turkish) coffee consumption on the plasma cardiovascular risk parameters of healthy subjects. The study also explores whether two unfiltered boiled (Turkish) coffee beverages that differ in content due to different roasting degrees will differentially affect cardiovascular biomarkers. Methods: In this crossover intervention study, healthy, nonsmoking, habitual Turkish coffee drinkers (n=28) were randomized to consume at least 3 cups of Light (LR) or Dark (DR) roast Turkish coffee brews per day for 4 weeks after a washout period (WO) of 2 weeks. Subsequent to each coffee abstinence period, both groups received the alternative intervention. After the first WO and the coffee intervention periods, anthropometric measures, blood pressure, heart rate and 13 biochemical parameters were collected and dietary records were completed.

Conditions

Cardiovascular Diseases

Keywords

Boiled coffee; Cardiovascular disease; Cholesterol; Homocysteine; Turkish coffee; Diterpenes; Unfiltered coffee

Outcome Measures

Primary Outcomes (1)

• Comparing the serum lipid levels of all interventions

  Differences in concentration of serum lipid levels of participants in coffee-free period (washout) and after LR or DR coffee ingestion were measured. Blood samples were obtained at the end of two weeks washout period and after each four weeks coffee intervention period, and sera were stored at -30∘ C, until analytical measurements were performed. The levels of serum lipids: Triglycerides (mg/dL), Total cholesterol (mg/dL), and HDL cholesterol (mg/dL) were determined using a Dimension Xpand Plus integrated clinical chemistry autoanalyzer (Siemens Healthcare Diagnostics, Deerfield, IL, USA). The serum levels of LDL cholesterol (mg/dL) were calculated using Friedewald's equation. Differences in blood lipid variables were analyzed by repeated-measures ANOVA for comparisons of LR coffee intake with DR and of each roast with the washout.analyses were performed using SPSS 24.0 (IBM-SPSS Inc., Chicago, IL, USA).

  12 weeks

Secondary Outcomes (11)

• Comparing the weight (kg) of all interventions

  12 weeks

• Comparing the height (cm) of all interventions

  12 weeks

• Comparing the body mass index (BMI) of all interventions

  12 weeks

• Comparing the body fat percentage (%) of all interventions

  12 weeks

• Comparing the waist circumference (cm) of all interventions

  12 weeks

Other Outcomes (2)

• Analysis of the content of the diterpenes (cafestol and kahweol) (mg/55mL) in LR and DR Turkish coffee brews

  3 months

• Analysis of the content of the caffeine (mg/mL) in LR and DR Turkish coffee brews

  3 months

Study Arms (4)

Washout period

EXPERIMENTAL

Coffee abstention phase for 2 weeks.

Other: coffee abstention phase

Light roast coffee (LR)

EXPERIMENTAL

Participants will follow LR Coffee consumption procedure and consume at least 3 cups of Light (LR) roast Turkish coffee brews per day for 4 weeks after a washout period (WO) of 2 weeks.

Other: LR Coffee consumption

Second washout period

EXPERIMENTAL

coffee abstention phase for 2 weeks

Other: coffee abstention phase

Dark roast coffee (DR)

EXPERIMENTAL

Participants will follow DR Coffee consumption procedure and consume at least 3 cups of Dark (DR) roast Turkish coffee brews per day for 4 weeks after a washout period (WO) of 2 weeks.

Other: DR Coffee consumption

Interventions

coffee abstention phase OTHER

no coffee consumption for 2 weeks

Second washout period; Washout period

LR Coffee consumption OTHER

for 4 weeks participants consumed only LR Turkish coffee

Light roast coffee (LR)

DR Coffee consumption OTHER

for 4 weeks participants consumed only DR Turkish coffee

Dark roast coffee (DR)

Eligibility Criteria

• Age: 20 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Regular Turkish coffee consumer ≥ 1 cups/day
• Body mass index (BMI) 18.5-24.9 kg/m2 )
• Non-smoker or former smoker (more than a year)
• Willingness to abstain from coffee drinking
• Willingness to consume ≥ 3 cups/day of Turkish coffee

You may not qualify if:

• Acute or chronic diseases
• Severe illness with in-patient treatment during last 3 months
• Use of regular medication or any supplements
• Weight reduction ˃2 kg/week during the last month
• Pregnancy or breastfeeding
• Regular strong physical activity with ≥1h/day
• High alcohol intake a weekly intake of ˃7 units for women and ˃14units for men
• Excess consumption of total fat ˃35% of daily calories
• Consumption of saturated fatty acid ˃10% of daily calories
• Cholesterol intake ˃300mg/day

Sponsors & Collaborators

• Eastern Mediterranean University: lead

Study Sites (1)

Eastern Mediterrenean University

Famagusta, 99450, Cyprus

Location

MeSH Terms

Conditions

Cardiovascular Diseases

Study Officials

• Tanju Besler, Prof.

  Eastern Mediterranean University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Instructor

Study Record Dates

• First Submitted: March 17, 2018
• First Posted: April 12, 2018
• Study Start: March 22, 2017
• Primary Completion: June 22, 2017
• Study Completion: October 22, 2017
• Last Updated: April 12, 2018

Record last verified: 2018-04

Locations

CY (1)