Apelin12 in Acne Vulgaris

NCT03480503 | Unknown

• 1 other identifier: SAAA
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous unit which is characterized by the formation of non-inflammatory open and closed comedones and inflammatory papules, pustules, nodules and cysts. It is a multifactorial disease that affects mostly adolescent population. Acne appears very early in puberty during the preteen years, often before menarche in girls. Because many adolescents have acne, it is difficult to predict which individuals are prone to severe cases. The pathogenesis of acne is complex, with strong evidence supporting the involvement of follicular hyperkeratinization, hyperactivity of the sebaceous glands, colonization of Propionibacterium acnes and yeast, and inflammation. Although the importance of androgens in the pathophysiology of acne has been supported by both clinical studies and experimental data, the research evaluating adipokines are very few in patients with acne vulgaris.

Conditions

Acne Vulgaris

Keywords

Apelin12

Outcome Measures

Primary Outcomes (1)

• serum apelin12

  blood samples will be taken then measurement of serum apelin12 by using ELISA technique after fasting 12 hours.

  12 hour

Secondary Outcomes (2)

• Complete lipid profile.

  12hour

• Fasting blood glucose

  7hours

Study Arms (2)

study group

Patients with acne vulgaris , measurement of serum apelin12 by using ELISA technique ,complete lipid profile and fasting blood glucose.

Control group

Healthy control volunteers, measurement of serum apelin12 by using ELISA technique ,complete lipid profile and fasting blood glucose.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will be performed at Department of Dermatology, Venereology and Andrology in Assiut University Hospital.

You may qualify if:

• Acne vulgaris patients from different ages and sex.

You may not qualify if:

• Pregnant and lactating females.
• Local cutaneous infection or any other dermatological diseases.
• Diabetic patients or severe systemic disease such as liver and renal failure.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (26)

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Biospecimen

Retention: SAMPLES WITH DNA

The venous blood sample will be taken from acne patients and control group after fasting for 10-12 hours and the following will be done: Fasting blood glucose. Complete lipid profile. Serum level of apelin-12 will be measured using enzyme linked immunosorbent assay(ELISA) technique .

MeSH Terms

Conditions

Acne Vulgaris

Condition Hierarchy (Ancestors)

Acneiform Eruptions; Skin Diseases; Skin and Connective Tissue Diseases; Sebaceous Gland Diseases

Central Study Contacts

Doaa Abu taleb, lecturer

CONTACT

01001463937; Dodda_aboutaleb@yahoo.com

Eman Kamal, assis prof

CONTACT

01005369338; emohanya@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 21, 2018
• First Posted: March 29, 2018
• Study Start: May 1, 2018
• Primary Completion: October 1, 2019
• Study Completion: December 1, 2019
• Last Updated: March 29, 2018

Record last verified: 2018-03