DAPSONE GEL7.5%Versus Trichloroacetic Acid 20% ON ACNE VULGARIS
Efficacy of Dapsone Gel 7.5%in Comparison to Trichloroacetic Acid 20% for Treatment of Acne Vulgaris :Split Face Study
1 other identifier
interventional
30
0 countries
N/A
Brief Summary
Acne vulgaris, a chronic inflammatory skin disorder, is one of the most prevalent diseases that effects more than 80% of the population worldwide . A variety of factors such as genetics, hormones, infections, as well as environmental factors have been identified as the causes of acne development . Acne usually generates as a result of blockage in the pilosebaceous unit (including hair follicle, hair shaft, and sebaceous gland) due to the over-produced sebum by sebaceous gland, which further triggers the excessive proliferation of the bacterium Propionibacterium acnes (P. Acnes).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_4
Started Sep 2022
Shorter than P25 for phase_4
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 16, 2022
CompletedFirst Posted
Study publicly available on registry
March 25, 2022
CompletedStudy Start
First participant enrolled
September 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2023
CompletedApril 1, 2022
March 1, 2022
1.1 years
March 16, 2022
March 24, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Efficacy of the medication:number of inflammatory ,non inflammatory and total lesions. counting the number of inflammatory ,non inflammatory and total lesions at baseline and every 4 weeks during the treatment
assessment of tolerability:interviewing the patients about any sign/symptoms of adverse reactions(erythema,peeling,burning sensation,dryness and pruritus)
12 weeks
Study Arms (1)
dapsone gel and trichloroacetic acid
EXPERIMENTALtrichloroacetic acid peeling on right side of face and dapsone gel on left side
Interventions
The patients will use topical dapsone gel 7.5% once daily on left side of face ,The patients will use TCA20% peeling as a peeling session every 2 weeks (6 sessions) on right side of face
Eligibility Criteria
You may qualify if:
- Both males and females will be included.
- Patients older than 12 years of age.
- Patients with mild and moderate AV.
- Patients had not received any topical or systemic treatment for AV during the previous 2 weeks
You may not qualify if:
- Severe acne.
- Patients under treatment with contraceptive pills or any kind of systemic or topic acne medication (isotretinoin, antibiotics, topical products).
- History of hypertrophic/keloid scar formation.
- Pregnancy, breast feeding.
- Recurrent herpes infection.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Atallah DA, Bestawy SR, Abouelmajd SA, Badran AY. Dapsone 7.5% Gel Versus Trichloroacetic Acid Peels. Dermatol Surg. 2025 Oct 3. doi: 10.1097/DSS.0000000000004896. Online ahead of print.
PMID: 41042170DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
dalia attallah, pof dr
assiut
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- principal investigator
Study Record Dates
First Submitted
March 16, 2022
First Posted
March 25, 2022
Study Start
September 1, 2022
Primary Completion
October 1, 2023
Study Completion
October 1, 2023
Last Updated
April 1, 2022
Record last verified: 2022-03
Data Sharing
- IPD Sharing
- Will share