Association of Anemia With Hospital Costs in Elective Colorectal Surgery

NCT03476707 | Completed Results

• 1 other identifier: DM9
• Study Type: observational
• Target: 851
• Locations: 0 countries
• Sites: N/A

Brief Summary

The objective is to measure the adjusted association between preoperative anemia and total hospital costs. We hypothesize that patients with anemia before surgery will have higher hospitalization costs than people without anemia.

Conditions

Surgery; Surgical Blood Loss; Anemia; Colon Cancer; Economic Problems

Outcome Measures

Primary Outcomes (1)

• Total Hospital Costs

  Direct and indirect costs accrued during the index hospitalization. Costs were measured using standard and validated algorithms, standardized to 2016 CAD. This method accounts for a patient's resource intensity weight, their case mix group, as well as fixed patient costs (e.g., medications, investigations) and indirect costs to the hospital based on patient's location of care (intensive care unit versus ward) and length of stay.

  Hospital admission to date of discharge from hospital, or 365 days after admission, whichever came first

Secondary Outcomes (2)

• Length of Stay

  Date of surgery to date of hospital discharge, or up to one year after surgery (whichever comes first)

• Red Blood Cell Transfusion

  Hospital admission to date of surgery, or 365 days after admission, whichever came first

Study Arms (2)

Anemic

People with a preoperative hematocrit less than 0.39

Other: Anemia

Non-anemic

People with a preoperative hematocrit greater than or equal to 0.39

Interventions

Anemia OTHER

Hematocrit less than 0.39

Anemic

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All adults having elective colorectal surgery with national surgical quality improvement program data available

You may qualify if:

• Elective hospital admission
• having colorectal surgery

You may not qualify if:

• not enrolled in national surgical quality improvement program data collection

Sponsors & Collaborators

• Ottawa Hospital Research Institute: lead

Related Publications (1)

• Feng S, Greenberg J, Moloo H, Thavorn K, McIsaac DI. Hospital cost associated with anemia in elective colorectal surgery: a historical cohort study. Can J Anaesth. 2019 Aug;66(8):877-885. doi: 10.1007/s12630-019-01379-8. Epub 2019 May 1.

  PMID: 31044414 DERIVED

MeSH Terms

Conditions

Blood Loss, Surgical; Anemia; Colonic Neoplasms

Condition Hierarchy (Ancestors)

Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Intraoperative Complications; Hematologic Diseases; Hemic and Lymphatic Diseases; Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases

Limitations and Caveats

Findings may not be generalizable to other jurisdictions with different hospital funding models and findings provide only an association between anemia and costs. There is risk of confounding bias due to unmeasured variables that might influence the presence of anemia or the accumulation of costs. The lack of integration of transfusion costs in our healthcare system required us to estimate the added cost of transfusions, and we were also unable to account for physician remuneration costs.

Results Point of Contact

• Title: Dr. Daniel McIsaac
• Organization: The Ottawa Hospital

dmcisaac@toh.ca

613-761-4940

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 19, 2018
• First Posted: March 26, 2018
• Study Start: January 1, 2010
• Primary Completion: December 1, 2016
• Study Completion: March 1, 2018
• Last Updated: September 24, 2024
• Results First Posted: September 24, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share