Effects of Succinylcholine on Nonintubated Thoracoscopic Surgery
Can Mini-dose Succinylcholine Accelerate Lung Collapse and Intrathoracic Nerve Blocks During Nonintubated Thoracoscopic Surgery? A Randomized Controlled Trial
1 other identifier
interventional
30
1 country
1
Brief Summary
A safe and effective surgical environment is important for nonintubated thoracoscopic surgery. The investigators hypothesize that mini-dose succinylcholine can induce ultra-short period of apnea, by which the ventilatory responses to open pneumothorax were abolished and may facilitate rapid and satisfying collapse of the operated lung during nonintubated thoracoscopic surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2018
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2018
CompletedFirst Submitted
Initial submission to the registry
March 13, 2018
CompletedFirst Posted
Study publicly available on registry
March 19, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
July 31, 2019
CompletedMarch 20, 2018
March 1, 2018
1.4 years
March 13, 2018
March 18, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Quality of lung collapse
Quality of lung collapse will be quantified by the surgeon as score 1-3.
20 minutes
Secondary Outcomes (1)
Arterial blood gas analysis
20 minutes
Study Arms (2)
Nonintubated VATS succinylcholine
EXPERIMENTALNonintubated VATS using mini-dose succinylcholine in the beginning of open pneumothorax
Nonintubated VATS placebo
PLACEBO COMPARATORNonintubated VATS not using succinylcholine in the beginning of open pneumothorax
Interventions
Giving mini-dose succinylcholine to facilitate lung collapse during nonintubated VATS.
Giving placebo (normal saline) to facilitate lung collapse during nonintubated VATS.
Eligibility Criteria
You may qualify if:
- Adults patients with lung tumors and elective for unilateral thoracoscopic surgery.
You may not qualify if:
- Over weighted, body mass index \> 26 kg/m2.
- Previous thoracic surgery on the attempted operative side.
- Hypoventilation syndrome requiring positive pressure ventilatory support or oxygen at home.
- Relevant systemic disease, including heart failure, liver failure, renal failure with an American Society of Anesthesiologists (ASA) class above 3.
- Difficult airway management.
- Pregnancy.
- Contraindications for succinylcholine, including family history of suspicious malignant hyperthermia, hyperkalemia, or other neuromuscular diseases.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Taiwan University Hospital
Taipei, 100, Taiwan
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ming-Hui Hung, MD, MSc
National Taiwan University Hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 13, 2018
First Posted
March 19, 2018
Study Start
March 1, 2018
Primary Completion
July 31, 2019
Study Completion
July 31, 2019
Last Updated
March 20, 2018
Record last verified: 2018-03