Early Versus Late Extubation in Myasthenia Gravis Patients

NCT03468452 | Completed DMC

• 1 other identifier: Timing of Extubation
• Study Type: observational
• Target: 96
• Locations: 0 countries
• Sites: N/A

Brief Summary

MYASTHENIA GRAVIS (MG) is an autoimmune disease characterized by varying degrees of muscle weakness and fatigability worsened with exertion and relieved with rest。Thymectomy plays an important role in the management of these patients because a consistent association between myasthenic and thymic pathology has been recognized.The need for prolonged mechanical ventilation in these patients after thymectomy is determined by their preoperative condition and various perioperative risk factors. Leventhal et al proposed a preoperative scoring system to predict the need for postoperative mechanical ventilation in myasthenic patients undergoing thymectomy based on the following 4 criteria: duration of MG, chronic respiratory disease, dose of pyridostigmine, and vital capacity. However, some investigators discovered that the Leventhal criteria may not be the sole benchmark and that other criteria such as severity of myasthenia,history of myasthenic crisis, and presence of thymoma may be more important in predicting the necessity for prolonged mechanical ventilation after thymectomy. Naguib et al described multivariate determinants of the need for postoperative ventilation after thymectomy in MG patients predominantly on the basis of pulmonary function tests. In addition, the prevalence and presentation of MG may be variable among different ethnic groups. However, there are very few large studies investigating the determinants of prolonged mechanical ventilation after thymectomy. The authors describe the parameters associated with prolonged mechanical ventilation after trans-sternal thymectomy at their institution.

Conditions

Myasthenia Gravis Associated With Thymoma

Outcome Measures

Primary Outcomes (1)

• Length of ICU stay

  Record the time spent in hospital for each patient

  through study completion, an average of 1 year

Study Arms (2)

Early extubation

The endotracheal tube is removed in the operation room, and no suction support is required after surgery.

Other: extubation

late extubation

Take the tracheal tube back to the ward for respiratory support or removal of air. The catheter is inserted again within 48h.

Other: extubation

Interventions

extubation OTHER

Time of extubation

Early extubation; late extubation

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

after thymectomy in patients with myasthenia gravis

You may qualify if:

• myasthenia gravis patients after thymectomy

You may not qualify if:

• not extubation

Sponsors & Collaborators

• First Affiliated Hospital, Sun Yat-Sen University: lead

MeSH Terms

Interventions

Airway Extubation

Intervention Hierarchy (Ancestors)

Airway Management; Therapeutics; Investigative Techniques

Study Officials

• Zhenguang Chen

  First Affiliated Hospital, Sun Yat-Sen University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 9, 2018
• First Posted: March 16, 2018
• Study Start: January 1, 2015
• Primary Completion: November 21, 2017
• Study Completion: December 11, 2017
• Last Updated: March 16, 2018

Record last verified: 2018-03

Data Sharing

• IPD Sharing: Will not share