Investigating Transcranial Direct Current Stimulation (tDCS) in Accelerating Learning in a Healthy Older Population

NCT03467698 | Completed Results FDA Device

• 1 other identifier: 18-40
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The overall objective of this study is to explore whether transcranial Direct Current Stimulation (tDCS) can accelerate associative learning and boost associative memory in healthy subjects.

Conditions

Associative Memory in Healthy Subjects

Keywords

Aging; Memory; Associative learning; transcranial direct current stimulation

Outcome Measures

Primary Outcomes (1)

• A Computerized Verbal Paired-associate Memory Task Will be Used to Assess Memory Performance.

  Memory performance scores recorded in the computerized verbal paired-associate memory test during each visit will be compared between the two groups (active tDCS and sham tDCS).

  Memory performance changes will be assessed in two different visits. First assessment (baseline) on visit 1 (learning), then one-week after during visit 2 (memory)

Study Arms (2)

Active tDCS

EXPERIMENTAL

active HD-tDCS will be administered

Device: Active tDCS

Sham tDCS

SHAM COMPARATOR

sham HD-tDCS will be administered

Device: Sham tDCS

Interventions

Active tDCS DEVICE

Real stimulation

Active tDCS

Sham tDCS DEVICE

Sham stimulation

Sham tDCS

Eligibility Criteria

• Age: 55 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 55 and 75
• Currently not using any medication contradicting with tDCS
• Native English speaker
• Capable of understanding and signing an informed consent

You may not qualify if:

• Acquainted with the Swahili language or culture
• Severe disease
• Mental illness
• Cardiac history
• History of severe head injuries
• History of epileptic insults
• Any implanted devices such as pace maker, neurostimulator
• Pregnancy

Sponsors & Collaborators

• The University of Texas at Dallas: lead

Study Sites (1)

University of Texas at Dallas

Richardson, Texas, 75080, United States

Location

Related Publications (1)

• Luckey AM, McLeod SL, Robertson IH, To WT, Vanneste S. Greater Occipital Nerve Stimulation Boosts Associative Memory in Older Individuals: A Randomized Trial. Neurorehabil Neural Repair. 2020 Nov;34(11):1020-1029. doi: 10.1177/1545968320943573. Epub 2020 Sep 23.

  PMID: 32964776 DERIVED

Results Point of Contact

• Title: UT Dallas IRB DIrector
• Organization: UT Dallas

amanda.boone@utdallas.edu

972-883-4506

Study Officials

• Sven Vanneste, PhD

  The University of Texas at Dallas

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Model Details: Participants will be randomly assigned to one of two groups: (1) active tDCS (2) Sham tDCS.

Study Record Dates

• First Submitted: February 28, 2018
• First Posted: March 16, 2018
• Study Start: February 21, 2018
• Primary Completion: September 17, 2022
• Study Completion: October 21, 2022
• Last Updated: January 9, 2024
• Results First Posted: January 9, 2024

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)