Trials Sponsors Conditions Drugs Pricing

Conditions

Cardiovascular Health Identify Oral Bacteria Responsible for Nitrate Reduction

Outcome Measures

Primary Outcomes (1)

Quantity of nitrate -reducing bacteria
Change in total quantity of nitrate-reducing bacteria as measured by sequencing bacterial 16S rRNA genes
14 days

Secondary Outcomes (6)

Nitric oxide bioavailability - plasma nitrite
14 days
Nitric oxide bioavailability - salivary nitrite
14 days
Nitric oxide bioavailability - plasma nitrate
14 days
Nitric oxide bioavailability - salivary nitrate
14 days
Blood pressure
14 days
+1 more secondary outcomes

Study Arms (3)

Nitrate-rich beetroot juice

ACTIVE COMPARATOR

2 x 70mL concentrated juice per day for 14 days

Dietary Supplement: Nitrate-rich beetroot juice

Nitrate-depleted beetroot juice

PLACEBO COMPARATOR

2 x 70mL concentrated juice per day for 14 days

Dietary Supplement: Nitrate-depleted beetroot juice

Antibacterial mouthwash

OTHER

2 x 10mL antibacterial mouthwash per day for 14 days

Other: Mouthwash

Interventions

Nitrate-rich beetroot juiceDietary supplement

concentrated beetroot juice

Nitrate-rich beetroot juice

Nitrate-depleted beetroot juiceDietary supplement

concentrated beetroot juice

Nitrate-depleted beetroot juice

Eligibility Criteria

Age18 Years - 80 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Healthy young (18-30 yr) and older adults (65-80 yr)
Male and female

Sponsors & Collaborators

University of Exeter
Otherlead

Study Sites (1)

Diabetes & Vascular Medicine Research Centre, Clinical Research Facility

Exeter, Devon, United Kingdom

MeSH Terms

Interventions

Mouthwashes

Intervention Hierarchy (Ancestors)

Biomedical and Dental MaterialsSpecialty Uses of ChemicalsChemical Actions and UsesCosmeticsManufactured MaterialsTechnology, Industry, and Agriculture

Study Officials

Andrew M Jones, PhD
University of Exeter
PRINCIPAL INVESTIGATOR

Enrollment

101 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: QUADRUPLE
Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose: BASIC SCIENCE
Intervention Model: CROSSOVER
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

December 19, 2017

First Posted

March 15, 2018

Study Start

January 10, 2018

Actual (reported)

The Effect of Dietary Nitrate on the Oral Microbiome

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (6)

Study Arms (3)

Nitrate-rich beetroot juice

Nitrate-depleted beetroot juice

Antibacterial mouthwash

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (6)

Study Arms (3)

Nitrate-rich beetroot juice

Nitrate-depleted beetroot juice

Antibacterial mouthwash

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations