Transmission of ESBL-producing Enterobacteriaceae
1 other identifier
observational
2,000
1 country
1
Brief Summary
The aim of this research project is to investigate the transmission of ESBL-producing Enterobacteriaceae on both, the level of bacterial strains and mobile genetic elements, and to determine the source of hospital-acquired infections.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2017
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2017
CompletedFirst Submitted
Initial submission to the registry
March 1, 2018
CompletedFirst Posted
Study publicly available on registry
March 14, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2026
November 17, 2025
November 1, 2025
9.8 years
March 1, 2018
November 14, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Infection/colonization proportion
The proportion of infection/colonization with genetically related isolates of ESBL-producing Enterobacteriaceae (primary outcome) of the overall infection/colonization rate will be determined and stratified for both, in and outpatient setting for species and time periods
through study completion, an average of 45months
Interventions
Data and biological sample collection
Eligibility Criteria
out and inpatients from University Hospital Basle
You may qualify if:
- aged above 1 year
- proven ESBL-PE carriage from any specimens obtained by routine clinical practice out and inpatients from University Hospital Basle from January 1st until December 31st 2019
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital Switzerland, Division of Infecteous Disease and Hospital Epidemiology
Basel, 4031, Switzerland
Related Publications (1)
Aguilar-Bultet L, Bagutti C, Egli A, Alt M, Maurer Pekerman L, Schindler R, Furger R, Eichenberger L, Roloff T, Steffen I, Huebner P, Stadler T, Tschudin-Sutter S. Identification of a Cluster of Extended-spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Sequence Type 101 Isolated From Food and Humans. Clin Infect Dis. 2021 Jul 15;73(2):332-335. doi: 10.1093/cid/ciaa1164.
PMID: 32776135DERIVED
Biospecimen
Enterobacteriaceae
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sarah Tschudin-Sutter, PD MD
Division of Infectious Disease and Hopital Epidemiology, University Hospital Basle
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 1, 2018
First Posted
March 14, 2018
Study Start
March 1, 2017
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
December 31, 2026
Last Updated
November 17, 2025
Record last verified: 2025-11