Right Ventricular Function During Liver Transplantation as Assessed by Transesophageal Echocardiography.

NCT03459924 | Unknown

• 1 other identifier: 79763817.9.0000.5257
• Study Type: observational
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

Cirrhotic patients undergoing liver transplantation might develop acute transient right ventricular dysfunction, ranging from mild to severe form. More than two decades ago, a number of studies with pulmonary artery catheters looked at this particular issue with controversial results. However, the pulmonary artery catheter as a monitor for right ventricular function (RVF) has several limitations, while the echocardiogram is deemed to be more accurate in this regard. Therefore, we sought to evaluate the RVF with the transesophageal echocardiogram, and particularly whether the RVF significantly varies during this procedure.

Conditions

Liver Transplant; Complications

Keywords

Right ventricular function; Liver transplantation; Transesophageal echocardiography

Outcome Measures

Primary Outcomes (1)

• Development of new right ventricular dysfunction during liver transplantation

  Signs of right ventricular dysfunction as assessed by transesophageal echocardiography

  Through study completion, after 1 year of data retrieval and analysis.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult cirrhotic patients who underwent a orthotopic liver transplantation

You may qualify if:

• Adult patients who underwent orthotopic liver transplantation from april 2012 to april 2013.

You may not qualify if:

• Pulmonary hypertension (any type)
• Cardiopulmonary disease (eg: chronic obstructive pulmonary disease (COPD), valvular heart disease, ischemic heart disease)
• Fulminant hepatitis.

Sponsors & Collaborators

• Universidade Federal do Rio de Janeiro: lead
• University of California, San Francisco: collaborator

Study Sites (1)

Federal University of Rio de Janeiro

Rio de Janeiro, 21941590, Brazil

Location

Related Publications (4)

• Ellis JE, Lichtor JL, Feinstein SB, Chung MR, Polk SL, Broelsch C, Emond J, Thistlethwaite JR, Roizen MF. Right heart dysfunction, pulmonary embolism, and paradoxical embolization during liver transplantation. A transesophageal two-dimensional echocardiographic study. Anesth Analg. 1989 Jun;68(6):777-82.

  PMID: 2660629 BACKGROUND

• De Wolf AM, Begliomini B, Gasior TA, Kang Y, Pinsky MR. Right ventricular function during orthotopic liver transplantation. Anesth Analg. 1993 Mar;76(3):562-8. doi: 10.1213/00000539-199303000-00020.

  PMID: 8452268 BACKGROUND

• Gouvea G, Diaz R, Auler L, Martinho JM. Evaluation of the right ventricular ejection fraction during orthotopic liver transplantation under propofol anaesthesia. Br J Anaesth. 2008 Aug;101(2):161-5. doi: 10.1093/bja/aen145. Epub 2008 Jun 4.

  PMID: 18534974 BACKGROUND

• Gouvea G, Diaz R, Auler L, Toledo R, Martinho JM. Right ventricular ejection fraction during orthotopic liver transplantation: does anesthetic technique make a difference? J Crit Care. 2010 Dec;25(4):657.e1-6. doi: 10.1016/j.jcrc.2010.02.005. Epub 2010 Apr 8.

  PMID: 20381292 BACKGROUND

Study Officials

• Nubia V Figueiredo, MSc, PhD

  Universidade Federal do Rio de Janeiro

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 27, 2018
• First Posted: March 9, 2018
• Study Start: February 27, 2018
• Primary Completion: January 1, 2019
• Study Completion: January 1, 2019
• Last Updated: March 9, 2018

Record last verified: 2018-03

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)