The Potential Role of Testosterone on Target Organ Damage in Postmenopausal Hypertensive Women

NCT03451747 | Unknown

• 1 other identifier: LanZhou
• Study Type: observational
• Target: 322
• Locations: 0 countries
• Sites: N/A

Brief Summary

The incidence of CVD-related deaths is generally higher in women than men. Postmenopausal changes in estrogen/androgen ratio that induce a relative androgen excess have been proposed as important factors in the higher prevalence of hypertension. Therefore, the investigators hypothesize that testosterone has potential role between hypertension and target organ damage in postmenopausal hypertensive women. And the objective is to evaluate the effects of testosterone between hypertension and target organ damage in postmenopausal hypertensive women.

Conditions

Hypertension

Keywords

hypertension; female

Outcome Measures

Primary Outcomes (3)

• Relative indexes of myocardial remodeling

  Cardiac structure (left ventricular mass index in grams for square meter) measurement.

  Baseline

• Ambulatory blood pressure monitoring

  Non-invasive ambulatory blood pressure monitoring (ABPM) was performed for every enrolled patient with an ABPM equipment.

  Baseline

• The level of testosterone (T)

  Blood samples used to analyze the levels of sexual hormones were collected between morning 8:00 and 9:00 after an overnight fast. Testosterone (T) units on nanogram per deciliter.

  Baseline

Study Arms (2)

postmenopausal hypertensive women

mached hypertensive men

Eligibility Criteria

• Age: 45 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A total of 322 hypertensive patients hospitalized in our department from 2016 to 2017 were enrolled. Included 161 postmenopausal hypertensive women and 161 mached hypertensive men.

You may qualify if:

• Clinical diagnosis of hypertension
• Women are all postmenopausal
• Men are matched with women.

You may not qualify if:

• Secondary hypertension
• Coronary disease
• Heart failure
• Arterial fibrillation
• Previous myocardial infarction
• Previous stroke
• Malignant disease
• Kidney failure
• Liver failure
• Neoplastic disease
• Severe neurological diseases
• Severe metabolic or organic decompensation
• Refuse to sign the informed consent form

Sponsors & Collaborators

• LanZhou University: lead

Related Publications (2)

• Zhang S, Yu H, Jing C, Liang W, Chen L, Lin Y, Li R, Yu J, Li N. Correlation between ambulatory blood pressure indices and sex hormone imbalance in hypertensive women with different menopausal durations: a cross-sectional study. Eur J Med Res. 2026 Jan 19;31(1):95. doi: 10.1186/s40001-025-03797-5.

  PMID: 41555389 DERIVED

• Li N, Ma R, Wang S, Zhao Y, Wang P, Yang Z, Jin L, Zhang P, Ding H, Bai F, Yu J. The potential role of testosterone in hypertension and target organ damage in hypertensive postmenopausal women. Clin Interv Aging. 2019 Apr 29;14:743-752. doi: 10.2147/CIA.S195498. eCollection 2019.

  PMID: 31118595 DERIVED

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 18, 2018
• First Posted: March 2, 2018
• Study Start: March 10, 2018
• Primary Completion: April 5, 2018
• Study Completion: April 5, 2018
• Last Updated: March 5, 2018

Record last verified: 2018-01