Postural Stability Deficiencies in Asymptomatic Individuals With HIV

NCT03446677 | Completed

• 1 other identifier: A2540114
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

Persons with HIV can present vestibular system impairments, affecting postural stability. There is scarce literature related to the contribution of the visual and somatosensory systems in maintaining postural stability in persons with HIV. The purpose of this study is to describe the sensory systems used to maintain postural stability and how the sources of sensory information contributes to postural stability in asymptomatic persons with HIV. Postural stability was measured in 20 asymptomatic persons with HIV (11 male, 9 female, aged 43 ± 8 years). Static postural stability was evaluated during eight conditions that perturbed the visual, somatosensory and vestibular inputs. A paired-samples t-test was conducted to compare center of pressure (COP), antero-posterior displacement (APD) and right-left displacement (RLD) on stable and unstable surface and to characterize each balance sensory system. There was a significant difference in the COP and APD of eyes open condition compared to the remaining conditions on stable surface. Furthermore, there was a significant difference in the COP, APD and RLD for the eyes open on a foam surface compared to the remaining conditions on an unstable surface. Postural instability can be detected in asymptomatic persons with HIV under challenging conditions, previous to the evident appearance of balance impairments.

Conditions

HIV; Balance; Vestibular Disorder; Somatosensory Disorders; Postural Stability

Keywords

HIV; Balance; Vestibular; Somatosensory; postural stability; center of pressure

Outcome Measures

Primary Outcomes (1)

• Postural Stability

  Postural stability was operationally defined by the center of pressure displacement measured by the MatScan® pressure mat. These sensors detect the displacement as the body sways anterior, posterior or laterally (right or left).

  Baseline

Study Arms (1)

Asymptomatic persons with HIV

EXPERIMENTAL

Other: Postural Stability Testing

Interventions

Postural Stability Testing OTHER

Each subject was instructed to stand in a static bipedal posture on the MatScan® pressure mat and performed 8 balance tasks. Data of center of pressure, antero-posterior sways and medial-lateral sways were collected in each of the conditions. Each task took 30 seconds to be performed. The first 4 tasks were performed with the mat on the hard surface of the floor. These 4 tasks are as follows: standing with eyes open, standing with eyes closed, standing with eyes open looking and actively moving head upward and downward, and standing with eyes closed and the head actively moving upward and downward. The subjects were asked to perform four more tasks while standing on a thick piece of balance foam that was placed on top of the MatScan®. The remaining 4 tasks are as follows: standing with eyes open, standing with eyes closed, standing with eyes open looking and actively moving the head upward and downward, and standing with eyes closed with head actively moving upward and downward.

Asymptomatic persons with HIV

Eligibility Criteria

• Age: 25 Years - 57 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• CD4 levels above 300,
• age within the range of 25-57 years
• walks without assistive device
• tolerates standing position for at least 30 minutes
• stable cardiorespiratory system.

You may not qualify if:

• diagnosis of AIDS (CD4 levels less than 200)
• diagnosis of Diabetes, Dementia or Arthritis
• severe neuropathy
• severe balance impairments
• severe visual acuity problems that are not treated
• BMI \> 40,
• decreased functional strength in the lower extremities
• severe proprioception impairments
• falls during the last 6 months
• back or lower extremities lesion or surgery during the last 6 months
• the use of medications that causes drowsiness 24 hours previous to intervention
• women that are pregnant or think they might be pregnant

Sponsors & Collaborators

• Texas Woman's University: lead

Related Publications (21)

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  BACKGROUND

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  BACKGROUND

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  BACKGROUND

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  BACKGROUND

Related Links

• National Institute of health. (2014). Visual acuity test.
• Vestibular disorders association. (2009). Vision Challenges with Vestibular Disorders.

MeSH Terms

Conditions

Vestibular Diseases; Somatosensory Disorders

Condition Hierarchy (Ancestors)

Labyrinth Diseases; Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Martin G Rosario, Ph.D

  Texas Woman's University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 11, 2018
• First Posted: February 27, 2018
• Study Start: July 22, 2014
• Primary Completion: May 22, 2015
• Study Completion: July 22, 2015
• Last Updated: February 27, 2018

Record last verified: 2018-02