Large Sample PD Patients and Healthy Controls

NCT03439163 | Completed

• 1 other identifier: TAOWU-PD
• Study Type: observational
• Target: 132
• Locations: 0 countries
• Sites: N/A

Brief Summary

Resting-state functional magnetic resonance imaging (RS-fMRI) has frequently been used to investigate local spontaneous brain activity in Parkinson's disease (PD) in a whole-brain, voxel-wise manner. To quantitatively integrate these studies, we conducted a coordinate-based meta-analysis on 15 studies that used amplitude of low frequency fluctuation (ALFF) and 11 studies that used regional homogeneity (ReHo). All these ALFF and ReHo studies have compared PD patients with healthy controls. We also performed a validation RS-fMRI study of ALFF and ReHo in a frequency-dependent manner for a novel dataset consisting of PD and healthy controls.

Conditions

Neuro-Degenerative Disease

Outcome Measures

Primary Outcomes (1)

• decreased spontaneous brain activity in PD patients

  We found a decreased spontaneous brain activity in left putamen in PD patients

  06/2015-01/2016

Study Arms (1)

PD patients

the entire group underwent MRI scan

Device: MRI scan

Interventions

MRI scan DEVICE

All participants underwent the MRI scan

PD patients

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

PD patients were enrolled from the inpatients and the outptients. Healthy controlls were enrolled using advertisement (media and internet)

You may qualify if:

• The PD diagnoses were based on the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria. Patients were assessed using the UPDRS III and Hoehn and Yahr disability scale.

You may not qualify if:

• any history of neuropsychiatric disorders.

Sponsors & Collaborators

• Xuanwu Hospital, Beijing: lead

Related Publications (2)

• Pan P, Zhan H, Xia M, Zhang Y, Guan D, Xu Y. Aberrant regional homogeneity in Parkinson's disease: A voxel-wise meta-analysis of resting-state functional magnetic resonance imaging studies. Neurosci Biobehav Rev. 2017 Jan;72:223-231. doi: 10.1016/j.neubiorev.2016.11.018. Epub 2016 Dec 1.

  PMID: 27916710 RESULT

• Pan P, Zhang Y, Liu Y, Zhang H, Guan D, Xu Y. Abnormalities of regional brain function in Parkinson's disease: a meta-analysis of resting state functional magnetic resonance imaging studies. Sci Rep. 2017 Jan 12;7:40469. doi: 10.1038/srep40469.

  PMID: 28079169 RESULT

Related Links

• The web site of DPABI software
• The web site of SDM software

Biospecimen

Retention: SAMPLES WITHOUT DNA

no biospecimen was collected

MeSH Terms

Interventions

Magnetic Resonance Imaging

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Tao Wu

  Xuanwu Hospital, Capital Medical University, Beijing

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 13, 2018
• First Posted: February 20, 2018
• Study Start: May 1, 2011
• Primary Completion: June 1, 2015
• Study Completion: January 1, 2016
• Last Updated: February 26, 2018

Record last verified: 2018-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: starting one year at least after publication
• Access Criteria: We will follow the two repositories' commands to share the data. The demography information will also be shared. Dr. Tao Wu will review the requests which is only used for scientific research.