Electronic Nose for Diagnosis of Neurodegenerative Diseases Via Breath Samples

NCT01291550 | Unknown

• 1 other identifier: 0196-09
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The diagnosis of neurodegenerative conditions and ADHD still mostly relies on clinical symptoms as there are no validated, inexpensive, and simple bio- markers available yet. The purpose of this study is to deliver a proof-of-concept for novel biomarkers to identify neurodegenerative conditions and ADHD based on breath testing. Alveolar breath will be collected from healthy volunteers, patients with extrapyramidal conditions, patients diagnosed with dementia and from ADHD subjects. The discriminative power of a tailor-made Nanoscale Artificial Nose (™NA-NOSE) containing an array of six nanomaterial-based sensors will be tested. Discriminant factor analysis will be applied to the NA-NOSE signals in order to detect statistically significant differences between the sub-populations, and classification success will be estimated using leave-one-out cross-validation. The identification of NA-NOSE patterns will be supported by analyzing the chemical composition of the breath using gas-chromatography in conjunction with mass-spectrometry (GC-MS).

Conditions

Neurodegenerative Diseases

Keywords

Detecting volatile biomarkers using breath sample

Study Arms (3)

Nerodegenerative diseases

Patients with parkinsonism and patients with dementia

Controls

ADHD

Subjects diagnosed with ADHD

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Out patient clinic patients diagnosed with neurodegenerative conditions healthy control and subjects diagnosed with ADHD.

You may qualify if:

• Patients diagnosed with neurodegenerative conditions
• Healthy subjects
• Subjects diagnosed with ADHD

Sponsors & Collaborators

• Rambam Health Care Campus: lead
• Technion, Israel Institute of Technology: collaborator

Study Sites (1)

Cognitive Neurology, Rambam Medical Center

Haifa, 31096, Israel

RECRUITING

Related Publications (1)

• Tisch U, Schlesinger I, Ionescu R, Nassar M, Axelrod N, Robertman D, Tessler Y, Azar F, Marmur A, Aharon-Peretz J, Haick H. Detection of Alzheimer's and Parkinson's disease from exhaled breath using nanomaterial-based sensors. Nanomedicine (Lond). 2013 Jan;8(1):43-56. doi: 10.2217/nnm.12.105. Epub 2012 Oct 15.

  PMID: 23067372 DERIVED

MeSH Terms

Conditions

Neurodegenerative Diseases

Condition Hierarchy (Ancestors)

Nervous System Diseases

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 7, 2011
• First Posted: February 8, 2011
• Study Start: September 1, 2010
• Last Updated: February 8, 2011

Record last verified: 2010-09

Locations

IL (1)