REducing SEDENTary Behaviour May Slow Cognitive Decline in Older Adults With Mild Cognitive Impairment: A Pilot Study

NCT03439059 | Completed

• 1 other identifier: RESEDENT study
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

With the nation's fastest growing demographic being adults over 65, one in every three seniors is estimated to die from Alzheimer's Disease (AD). The strong correlation between AD and age, combined with the exponential growth of this demographic, highlights the need for non-pharmaceutical treatment/prevention strategies. Research has established a relationship between moderate to vigorous physical activity (PA) and improved cognitive functioning. However, there is insufficient evidence to support this relationship at the lower end of the PA spectrum. Assisted living facilities (ALF) are an easy target for reducing SB, as many individuals in these facilities have various functional limitations and therefore cannot meet the recommended PA guidelines. Older adults are also the most sedentary population, with results showing over 8.5+ hours daily spent in SB. ALF typically provide meals, laundry services as well as housekeeping duties, leaving the residents very susceptible to large amounts of SB. The primary purpose of my study is investigating how reducing sedentary behaviour (SB) in ALF will affect Alzheimer's Disease Assessment Scale-cognitive scores among older adults aged 65 and older with mild-to-moderate cognitive impairment. I will also investigate its effects on physical functioning with the Timed Up and Go test (TUG) and quality of life with the Short Form 36 (SF-36) Health Survey. Participants will be prompted to take a 10-minute light intensity PA break at three different time points throughout the day, reallocating SB to any task equating to over 1.5 metabolic equivalents. Positive findings may encourage ALF to implement policies and procedures regarding SB.

Conditions

Cognitive Impairment; Physical Functioning; Quality of Life

Keywords

Older adults; Sedentary behaviour; Assisted living; cognitive function

Outcome Measures

Primary Outcomes (1)

• Alzheimers Disease Assessment Scale- Cognitive (ADAS-cog)

  The ADAS-Cog Sub-Scale is the standard cognitive outcome measure used in clinical trials for patients with mild to moderate Alzheimer's disease. The test consists of 11 brief cognitive tests assessing memory, language, praxis, attention and other cognitive abilities. Scores range from 0 to 70, with higher scores indicating greater severity of cognitive impairment

  10 weeks

Secondary Outcomes (2)

• Short Form 36 Health Survey

  10 weeks

• Timed Up and Go test

  10 weeks

Study Arms (2)

intervention- reducing SB

EXPERIMENTAL

prompted to do 10min of light physical activity 3x/day

Behavioral: Reducing Sedentary Behaviour Group

Control

NO INTERVENTION

go about their normal daily living

Interventions

Reducing Sedentary Behaviour Group BEHAVIORAL

Participants will be prompted to perform 10min of light physical activity (\>1.5 METS) 3x/day for 6 weeks

intervention- reducing SB

Eligibility Criteria

• Age: 65 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

Inclusions: * aged 65+ years old * residing in the ALF permanently * able to read, write and understand English * answer "yes" to "do you have difficulty with your memory" * get consent from their physician to participate in the study * diagnosed with mild- moderate cognitive impairment by obtaining a score of 14-29, inclusive, on the Mini Mental State Examination (Folstein, Folstein, \& McHugh, 1975). Exclusions: * any physical condition or disability disallowing participation in PA * apparent evidence of any neurodegenerative disorders other than Alzheimer's disease * score of 6 or higher on the Geriatric Depression Scale (Almeida, 1999), due to the apparent presence of clinically significant depressive symptoms and finally

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Western University, Canada: lead

Study Sites (1)

Western University

London, Ontario, N6G 1G9, Canada

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Harry Prapavessis, Ph.D

  Western University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 9, 2018
• First Posted: February 20, 2018
• Study Start: June 1, 2018
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: March 4, 2024

Record last verified: 2019-01

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)