Effect of the Administration of L-Carnitine on Body Weight in Women in Crossfit Training
1 other identifier
interventional
24
1 country
1
Brief Summary
The L-carnitine has demonstrated effects in the treatment of obesity mainly promoting the fat degradation during exercise.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_2
Started Dec 2018
Shorter than P25 for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 11, 2018
CompletedFirst Posted
Study publicly available on registry
February 19, 2018
CompletedStudy Start
First participant enrolled
December 17, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2019
CompletedFebruary 20, 2018
February 1, 2018
2 months
February 11, 2018
February 18, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Body Fat
Calulated by Durnin formula. Results are reported in percentage and kg
8 weeks
Lean body mass
Calulated by Durnin formula. Results are reported in percentage and kg
8 weeks
Body Weight
Subject go up onto the scale and stand still over the center of the scale with body weight evenly distributed between both feet. Omron hbf-514c an digital scale and results are reported in kg with a decimal.
8 weeks
Secondary Outcomes (3)
Arm muscle circumference
8 weeks
Waist circumference
8 weeks
Body Mass Index
8 weeks
Study Arms (2)
Placebo
PLACEBO COMPARATORSucralose 1,5 g
L-Carnitine
EXPERIMENTALL- Carnitine 1,5 g
Interventions
L-Carnitine oral solution 1.5 g diluted in 250 ml of water, before crossfit training, 5 times a week for 8 weeks
Sucralose 1.5 g diluted in 250 ml of water, before crossfit training, 5 times a week for 8 weeks
Eligibility Criteria
You may qualify if:
- Volunteers who practice crossfit regularly (who have 3 months prior to the beginning of the study practicing crossfit).
- Volunteers with a body mass index equal to or greater than 25 Kg/m2.
- Volunteers who do not have allergies to L-Carnitine or any of its components.
- Informed consent signed
- Women with a recommendation of nutrition two weeks prior to the start of the study.
- Body weight stable the last 3 months.
You may not qualify if:
- Volunteers with pathologies such as diabetes, hypertension, metabolic syndrome and allergies.
- Women with confirmed or suspected pregnancy.
- Women under lactation and/or puerperium.
- Hypersensibilility to L-Carnitine or Sucralose.
- Kown of renal, hepatic or thyroid deseased.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Centro Universitario de Tonalá
Tonalá, Jalisco, 45425, Mexico
Related Publications (6)
Huang A, Owen K. Role of supplementary L-carnitine in exercise and exercise recovery. Med Sport Sci. 2012;59:135-142. doi: 10.1159/000341934. Epub 2012 Oct 15.
PMID: 23075564BACKGROUNDVillani RG, Gannon J, Self M, Rich PA. L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women. Int J Sport Nutr Exerc Metab. 2000 Jun;10(2):199-207. doi: 10.1123/ijsnem.10.2.199.
PMID: 10861338BACKGROUNDHongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women. J Nutr. 2003 Jan;133(1):84-9. doi: 10.1093/jn/133.1.84.
PMID: 12514272BACKGROUNDBroad EM, Maughan RJ, Galloway S DR. Effects of exercise intensity and altered substrate availability on cardiovascular and metabolic responses to exercise after oral carnitine supplementation in athletes. Int J Sport Nutr Exerc Metab. 2011 Oct;21(5):385-97. doi: 10.1123/ijsnem.21.5.385. Epub 2011 Aug 3.
PMID: 21813919BACKGROUNDBehrend AM, Harding CO, Shoemaker JD, Matern D, Sahn DJ, Elliot DL, Gillingham MB. Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation. Mol Genet Metab. 2012 Jan;105(1):110-5. doi: 10.1016/j.ymgme.2011.09.030. Epub 2011 Oct 1.
PMID: 22030098BACKGROUNDKraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exerc. 2006 Jul;38(7):1288-96. doi: 10.1249/01.mss.0000227314.85728.35.
PMID: 16826026BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Diana M Hernández
University of Guadalajara
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD of Pharmacology
Study Record Dates
First Submitted
February 11, 2018
First Posted
February 19, 2018
Study Start
December 17, 2018
Primary Completion
February 1, 2019
Study Completion
May 1, 2019
Last Updated
February 20, 2018
Record last verified: 2018-02