Changes of Ocular Structures After Hemodialysis in Patients With Chronic Kidney Diseases

NCT03434145 | Completed DMC

• 1 other identifier: 2016-05-005
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate the effect of hemodialysis on various ophthalmologic parameters in patients with end-stage kidney disease (ESRD).

Conditions

Chronic Kidney Diseases; Hemolysis

Outcome Measures

Primary Outcomes (1)

• changes of retinal and choroidal thickness after hemodialysis

  retinal \& choroidal thickness on OCT

  immediately (within 10 minutes) before and after hemodialysis

Secondary Outcomes (2)

• changes of foveal vascular density using optical coherence tomography-angiography (OCTA) after hemodialysis

  immediately (within 10 minutes) before and after hemodialysis

• the effect of hemodialysis (HD) on anterior chamber angle by anterior segment optical coherence

  immediately (within 10 minutes) before and after hemodialysis

Study Arms (1)

patients with chronic kidney diseases

patients with end stage retinal disease undergoing hemodialysis underwent various ophthalmologic exams before and after hemodialysis.

Other: ophthalmologic exams

Interventions

ophthalmologic exams OTHER

ophthalmologic exams such as vision, intraocular pressure, axial length and optical coherence tomography

patients with chronic kidney diseases

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients with end-stage renal disease who undergoing hemodialysis

You may qualify if:

• \) patients who are regularly dialyzed in our dialysis room to participate in the study
• \) patients who agree with our study protocol
• \) patients who have unstable general condition

You may not qualify if:

• \) previous intraocular surgery, (2) baseline IOP greater than 22 mmHg, (3) presence of glaucomatous optic disc changes including excavation, thinning, or notching of the neuroretinal rim, (4) axial length greater than 26 mm, and (5) combined macular and retinal diseases such as central serous chorioretinopathy and age-related macular degeneration, except diabetic retinopathy.

Sponsors & Collaborators

• Hanyang University: lead

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Hemolysis

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Heeyoon Cho, MD

  Hanyang University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: February 5, 2018
• First Posted: February 15, 2018
• Study Start: September 9, 2016
• Primary Completion: September 7, 2017
• Study Completion: December 29, 2017
• Last Updated: February 15, 2018

Record last verified: 2018-02

Data Sharing

• IPD Sharing: Will not share