Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation

NCT03433105 | Completed

• 1 other identifier: 201710003RINB
• Study Type: observational
• Target: 157
• Locations: 1 country
• Sites: 1

Brief Summary

1.Research hypothesis: during weaning patient from prolonged mechanical ventilation, if the work load caused by weaning was below the patient's AT, oxygen uptake will be constant. Otherwise, if the work load was above the patient's AT, the oxygen uptake will increase.

1. 1.Patient: who have tracheostomy tubes and with prolonged mechanical ventilation
2. 2.Measurement: oxygen uptake(V̇O2) and respiratory mechanics during the spontaneous breathing trials
3. 3.Outcome: Correlation between the oxygen uptake(V̇O2) and the weaning outcome
4. 4.to investigate the prognostic value of oxygen uptake in weaning patients from prolonged mechanical ventilation
5. 5.Subgroup analysis may suggest which weaning protocol potentially benefit the most for each population group (cardiovascular disease, chronic pulmonary disease, neuromuscular disease, cerebrovascular disease)

Conditions

Ventilator Weaning

Keywords

oxygen uptake; prolonged mechanical ventilation; weaning

Outcome Measures

Primary Outcomes (1)

• Measurement of oxygen uptake (V̇O2)

  oxygen uptake during the spontaneous breathing trial

  up to 12 hours during the spontaneous breathing trial

Study Arms (1)

1/patients with tracheostomy tubes and prolonged MV use

Patients who have tracheostomy tubes and with prolonged mechanical ventilation

Eligibility Criteria

• Age: 20 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patient who have tracheostomy tubes and with prolonged mechanical ventilation

You may qualify if:

• Adult \>20 y/o Total duration of mechanical ventilation ≥ 10 days Received tracheostomy Defervescence Meeting the criteria of weaning phase (see supplementary protocols)

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

Location

Study Officials

• Yao-Wen Kuo, MD

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 23, 2018
• First Posted: February 14, 2018
• Study Start: January 23, 2018
• Primary Completion: August 14, 2020
• Study Completion: August 14, 2020
• Last Updated: October 8, 2020

Record last verified: 2019-09

Locations

TW (1)