Role of Choline PET/CT in Predicting Survival in Patients With Hepatocellular Carcinoma

NCT03430635 | Completed

• 1 other identifier: CholinePETforHCC
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

¹¹C-choline positron emission tomography/computed tomography (PET/CT) has been used in patients with some types of solid cancers, but few data are available in patients undergoing hepatectomy for hepatocellular carcinoma (HCC). The aim of this study was to analyze the prognostic value of metabolic imaging data by using ¹¹C-choline PET/CT in patients with HCC before hepatectomy.

Conditions

Hepatocellular Carcinoma

Outcome Measures

Primary Outcomes (1)

• Identification of PET/CT parameters that can be predictors of survival

  Identification of specific PET/CT parameters that can be used as independent predictors of overall and/or disease-free survival

  From date of surgery until the date of first documented progression or date of death from any cause, whichever came first assessed up to 72 months

Interventions

Hepatectomy PROCEDURE

Surgery of the liver: removal of a given part of the liver affected by hepatocellular carcinoma

Also known as: Hepatic resection; liver resection.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients affected by HCC candidate to surgical resection that were preoperatively staged with ¹¹C-choline PET/CT.

You may qualify if:

• Any patient with HCC candidate to surgical resection preoperatively staged with ¹¹C-choline PET/CT

You may not qualify if:

• R2 resection;
• Intraoperative use of RFA/MWI
• Postoperative death (90-days)

Sponsors & Collaborators

• Humanitas Clinical and Research Center: lead

Related Publications (2)

• Lanza E, Donadon M, Felisaz P, Mimmo A, Chiti A, Torzilli G, Balzarini L, Lopci E. Refining the management of patients with hepatocellular carcinoma integrating 11C-choline PET/CT scan into the multidisciplinary team discussion. Nucl Med Commun. 2017 Oct;38(10):826-836. doi: 10.1097/MNM.0000000000000719.

  PMID: 28723716 BACKGROUND

• Lopci E, Torzilli G, Poretti D, de Neto LJ, Donadon M, Rimassa L, Lanza E, Sabongi JG, Ceriani R, Personeni N, Palmisano A, Pedicini V, Comito T, Scorsetti M, Chiti A. Diagnostic accuracy of (1)(1)C-choline PET/CT in comparison with CT and/or MRI in patients with hepatocellular carcinoma. Eur J Nucl Med Mol Imaging. 2015 Aug;42(9):1399-407. doi: 10.1007/s00259-015-3079-5. Epub 2015 May 12.

  PMID: 25962590 BACKGROUND

MeSH Terms

Conditions

Carcinoma, Hepatocellular

Interventions

Hepatectomy

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Liver Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases

Intervention Hierarchy (Ancestors)

Digestive System Surgical Procedures; Surgical Procedures, Operative

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Surgery

Study Record Dates

• First Submitted: January 20, 2018
• First Posted: February 13, 2018
• Study Start: January 1, 2010
• Primary Completion: December 31, 2015
• Study Completion: January 31, 2016
• Last Updated: February 13, 2018

Record last verified: 2018-02